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Literature summary for 1.4.3.13 extracted from

  • Rodriguez, C.; Martinez-Gonzalez, J.; Raposo, B.; Alcudia, J.F.; Guadall, A.; Badimon, L.
    Regulation of lysyl oxidase in vascular cells: lysyl oxidase as a new player in cardiovascular diseases (2008), Cardiovasc. Res., 79, 7-13.
    View publication on PubMed
Search for more literature for 1.4.3.13

Activating Compound

Activating Compound Comment Organism Structure
transforming growth factor beta increases LOX expression and activity Mus musculus

Application

Application Comment Organism
medicine LOX could play a key role in vascular homeostasis and, hence, it emerges as a new player in cardiovascular diseases Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
homocysteine
-
 Mus musculus
low-density lipoprotein decreases lysyl oxidase mRNA levels in endothelial cells Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Cu2+ dependent Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cardiovascular system
-
 Mus musculus
-
coronary artery
-
 Mus musculus
-
endothelium
-
 Mus musculus
-
fibroblast
-
 Mus musculus
-
vascular smooth muscle cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
peptidyl-L-lysyl-peptide + O2 + H2O
-
 Mus musculus peptidyl-allysyl-peptide + NH3 + H2O2
-
 ?

Synonyms

Synonyms Comment Organism
LOX
-
 Mus musculus
lysyl oxidase
-
 Mus musculus