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Literature summary for 1.4.3.13 extracted from
- Comparative immunocytochemical localization of lysyl oxidase (LOX) and the lysyl oxidase-like (LOXL) proteins: changes in the expression of LOXL during development and growth of mouse tissues (2004), J. Mol. Histol., 35, 845-855.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | LOX and LOXL | Mus musculus | - |
- |
| nucleus | LOX and LOXL, of epithelial cells | Mus musculus | 5634 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Cu2+ | copper amine oxidase | Mus musculus |  |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 52000 | - |
x * 52000, extracellular LOXL, SDS-PAGE | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | LOX is essential for collagen and elastin matrix stability and newborn animal survival | ? | - |
? | |
| peptidyl-L-lysyl-peptide + O2 + H2O | Mus musculus | formation of cross-links in mature fibrillar collagen and elastin fibers in the extracellular space | peptidyl-allysyl-peptide + NH3 + H2O2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
C57BL/6 mice, enzyme forms: lysyl oxidase LOX and lysyl oxidase-like protein LOXL | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| alveolus | - |
Mus musculus | - |
| aorta | co-localization of LOX and LOXL | Mus musculus | - |
| brain | localization of LOX and LOXL in different tissue areas | Mus musculus | - |
| bronchiole | LOX and LOXL | Mus musculus | - |
| bronchus | LOX and LOXL | Mus musculus | - |
| cartilage | co-localization of LOX and LOXL | Mus musculus | - |
| cell culture | - |
Mus musculus | - |
| cerebral cortex | LOX on the surface of pyramidal cells in the grey matter, LOXL in the nuclei of cortex cells and in the cytosol of capillary endothelial cells | Mus musculus | - |
| choroid plexus | localization of LOX and LOXL in different tissue areas | Mus musculus | - |
| colon | localization of LOX and LOXL in different tissue areas, LOXL is found in the apical surface of columnar absorbing cells, LOX is located in the submucosa | Mus musculus | - |
| epidermis | of skin: LOX and LOXL | Mus musculus | - |
| epithelium | of lung: LOX and LOXL, renal tubules: only LOXL, intestinal: only LOXL | Mus musculus | - |
| gastric pit | of the stomach, mainly LOXL, mucous-secreting cells | Mus musculus | - |
| hair follicle | including dermal papillae, follicular sheaths, sebaceous glands | Mus musculus | - |
| heart | co-localization of LOX and LOXL | Mus musculus | - |
| hippocampus | pyramidal cells: LOXL, not LOX | Mus musculus | - |
| intestine | epithelial cells, LOXL | Mus musculus | - |
| keratinocyte | LOX and LOXL, of skin epidermis and hair follicles | Mus musculus | - |
| kidney | localization of LOX and LOXL in different tissue areas | Mus musculus | - |
| liver | co-localization of LOX and LOXL | Mus musculus | - |
| lung | co-localization of LOX and LOXL in alveoli and the epithelia of bronchus and bronchiole | Mus musculus | - |
| additional information | nearly no enzyme content in blood vessels, expression level of LOX and LOXL in different tissues during development from embryonic, newborn, and young to adult mice, overview | Mus musculus | - |
| ovary | localization of LOX and LOXL in different tissue areas | Mus musculus | - |
| peptic chief cell | pepsin-secreting, in the basal part of the stomach, only LOX, no LOXL | Mus musculus | - |
| renal tubule | LOXL | Mus musculus | - |
| retina | localization of LOX and LOXL in different tissue areas, LOX is located in the inner surface of the pigmented epithelia in the photoreceptor layer, LOXL is located in the inner nuclear layer within the outer plexiform layer and in the ganglion cells | Mus musculus | - |
| skin | co-localization of LOX and LOXL | Mus musculus | - |
| small intestine | - |
Mus musculus | - |
| smooth muscle | LOXL, lamia propria and straited border, not of Goblet cells | Mus musculus | - |
| stomach | localization of LOX and LOXL in different tissue areas | Mus musculus | - |
| testis | localization of LOX and LOXL in different tissue areas | Mus musculus | - |
| tongue | - |
Mus musculus | - |
| vegetative cell | proliferating cell, LOXL expression, adult tissues | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | LOX is essential for collagen and elastin matrix stability and newborn animal survival | Mus musculus | ? | - |
? | |
| peptidyl-L-lysyl-peptide + O2 + H2O | - |
Mus musculus | peptidyl-allysyl-peptide + NH3 + H2O2 | - |
? | |
| peptidyl-L-lysyl-peptide + O2 + H2O | formation of cross-links in mature fibrillar collagen and elastin fibers in the extracellular space | Mus musculus | peptidyl-allysyl-peptide + NH3 + H2O2 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 52000, extracellular LOXL, SDS-PAGE | Mus musculus |
| More | LOX and LOXL are immunologically distinct, specific antibodies do not cross-react | Mus musculus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| LOX | - |
Mus musculus |
| LOXL | - |
Mus musculus |
| lysyl oxidase | - |
Mus musculus |
| lysyl oxidase-like protein | - |
Mus musculus |
| More | enzymes belong to the lysyl oxidase family of copper amine oxidases | Mus musculus |
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