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Literature summary for 1.4.1.8 extracted from

  • Nguyen, K.T.; Nguyen, L.T.; Behal, V.
    The introduction of valine dehydrogenase activity from Streptomyces by L-valine is not repressed by ammonium (1995), Biotechnol. Lett., 17, 31-34.
No PubMed abstract available
Search for more literature for 1.4.1.8

Activating Compound

Activating Compound Comment Organism Structure
L-valine L-valine in growth medium induces VDH activity, not interfered by ammonia Streptomyces fradiae
L-valine L-valine in growth medium induces VDH activity, not interfered by ammonia Kitasatospora aureofaciens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-valine + NAD(P)+ + H2O Streptomyces fradiae metabolic connection between valine catabolism and biosynthesis of macrolide or polyether antibiotics 2-oxoisovalerate + NH3 + NAD(P)H
-
 ?
L-valine + NAD(P)+ + H2O Kitasatospora aureofaciens metabolic connection between valine catabolism and biosynthesis of macrolide or polyether antibiotics 2-oxoisovalerate + NH3 + NAD(P)H
-
 ?
L-valine + NAD(P)+ + H2O Streptomyces fradiae first step in valine catabolism 2-oxoisovalerate + NH3 + NAD(P)H
-
 ?
L-valine + NAD(P)+ + H2O Kitasatospora aureofaciens first step in valine catabolism 2-oxoisovalerate + NH3 + NAD(P)H
-
 ?
L-valine + NAD(P)+ + H2O Kitasatospora aureofaciens BS-5 metabolic connection between valine catabolism and biosynthesis of macrolide or polyether antibiotics 2-oxoisovalerate + NH3 + NAD(P)H
-
 ?
L-valine + NAD(P)+ + H2O Kitasatospora aureofaciens BS-5 first step in valine catabolism 2-oxoisovalerate + NH3 + NAD(P)H
-
 ?
L-valine + NAD(P)+ + H2O Streptomyces fradiae 30/3 metabolic connection between valine catabolism and biosynthesis of macrolide or polyether antibiotics 2-oxoisovalerate + NH3 + NAD(P)H
-
 ?
L-valine + NAD(P)+ + H2O Streptomyces fradiae 30/3 first step in valine catabolism 2-oxoisovalerate + NH3 + NAD(P)H
-
 ?

Organism

Organism UniProt Comment Textmining
Kitasatospora aureofaciens
-
-
-
Kitasatospora aureofaciens
-
 crude extract
-
Kitasatospora aureofaciens BS-5
-
-
-
Streptomyces fradiae
-
-
-
Streptomyces fradiae
-
 crude extract
-
Streptomyces fradiae 30/3
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 effect of L-valine and ammonium in different growth media on the VDH specific activity in crude extract Streptomyces fradiae
additional information
-
 effect of L-valine and ammonium in different growth media on the VDH specific activity in crude extract Kitasatospora aureofaciens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-valine + NAD(P)+ + H2O
-
 Streptomyces fradiae 2-oxoisovalerate + NH3 + NAD(P)H
-
 ?
L-valine + NAD(P)+ + H2O
-
 Kitasatospora aureofaciens 2-oxoisovalerate + NH3 + NAD(P)H
-
 ?
L-valine + NAD(P)+ + H2O metabolic connection between valine catabolism and biosynthesis of macrolide or polyether antibiotics Streptomyces fradiae 2-oxoisovalerate + NH3 + NAD(P)H
-
 ?
L-valine + NAD(P)+ + H2O metabolic connection between valine catabolism and biosynthesis of macrolide or polyether antibiotics Kitasatospora aureofaciens 2-oxoisovalerate + NH3 + NAD(P)H
-
 ?
L-valine + NAD(P)+ + H2O first step in valine catabolism Streptomyces fradiae 2-oxoisovalerate + NH3 + NAD(P)H
-
 ?
L-valine + NAD(P)+ + H2O first step in valine catabolism Kitasatospora aureofaciens 2-oxoisovalerate + NH3 + NAD(P)H
-
 ?
L-valine + NAD(P)+ + H2O
-
 Kitasatospora aureofaciens BS-5 2-oxoisovalerate + NH3 + NAD(P)H
-
 ?
L-valine + NAD(P)+ + H2O metabolic connection between valine catabolism and biosynthesis of macrolide or polyether antibiotics Kitasatospora aureofaciens BS-5 2-oxoisovalerate + NH3 + NAD(P)H
-
 ?
L-valine + NAD(P)+ + H2O first step in valine catabolism Kitasatospora aureofaciens BS-5 2-oxoisovalerate + NH3 + NAD(P)H
-
 ?
L-valine + NAD(P)+ + H2O
-
 Streptomyces fradiae 30/3 2-oxoisovalerate + NH3 + NAD(P)H
-
 ?
L-valine + NAD(P)+ + H2O metabolic connection between valine catabolism and biosynthesis of macrolide or polyether antibiotics Streptomyces fradiae 30/3 2-oxoisovalerate + NH3 + NAD(P)H
-
 ?
L-valine + NAD(P)+ + H2O first step in valine catabolism Streptomyces fradiae 30/3 2-oxoisovalerate + NH3 + NAD(P)H
-
 ?