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Literature summary for 1.4.1.3 extracted from

  • Suzuki, A.
    Glutamate synthase and amino acid synthesis in higher plants (2021), Adv. Bot. Res., 100, 129 .
No PubMed abstract available

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Arabidopsis thaliana 5739
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-glutamate + H2O + NAD+ Arabidopsis thaliana
-
2-oxoglutarate + NH3 + NADH + H+
-
r
L-glutamate + H2O + NADP+ Arabidopsis thaliana
-
2-oxoglutarate + NH3 + NADPH + H+
-
r

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana Q43314 AND Q38946 alpha and beta subunits, encoded by GDH1 and GDH2
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Source Tissue

Source Tissue Comment Organism Textmining
leaf
-
Arabidopsis thaliana
-
mesophyll
-
Arabidopsis thaliana
-
vascular bundle
-
Arabidopsis thaliana
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-glutamate + H2O + NAD+
-
Arabidopsis thaliana 2-oxoglutarate + NH3 + NADH + H+
-
r
L-glutamate + H2O + NADP+
-
Arabidopsis thaliana 2-oxoglutarate + NH3 + NADPH + H+
-
r

Synonyms

Synonyms Comment Organism
At5g07440 gene name, beta-subunit Arabidopsis thaliana
At5g18170 gene name, alpha-subunit Arabidopsis thaliana
GDH1 gene name, alpha-subunit Arabidopsis thaliana
GDH2 gene name, beta-subunit Arabidopsis thaliana
NADH-GDH
-
Arabidopsis thaliana
NADH-glutamate dehydrogenase
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Arabidopsis thaliana

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Arabidopsis thaliana
NADH
-
Arabidopsis thaliana
NADP+
-
Arabidopsis thaliana
NADPH
-
Arabidopsis thaliana

General Information

General Information Comment Organism
metabolism the enzyme is involved in the nitrogen distribution during primary assimilation, photorespiratory re-assimilation and translocation in Arabidopsis thaliana, overview. Traditional route of glutamate formation via the 2-oxoglutarate amination with NH4+ is persued by mitochondrial NADH-glutamate dehydrogenase Arabidopsis thaliana
physiological function in vitro, GDH catalyzes the reversible deamination of Glu to NH4 +, 2-oxoglutarate forming NADH. The reversible lethal phenotype of gltS mutants reveals that mitochondrial NADH-GDH is unable to re-assimilate photorespiratory NH3 produced within the same organelle although its amination activity. In vitro is several fold higher than the glutamate synthase isozyme Fd-GOGAT (EC 1.4.7.1) activity. The in vivo direction of reversible NADH-GDH reaction is controversial. NADH-GDH can exist as two homohexamers of either alpha subunit encoded by GDH1 or beta subunit encoded by GDH2 and five heterohexamers containing both alpha and beta subunits in Arabidopsis thaliana as observed in other plants Arabidopsis thaliana