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Literature summary for 1.4.1.3 extracted from

  • Spanaki, C.; Kotzamani, D.; Plaitakis, A.
    Widening spectrum of cellular and subcellular expression of human GLUD1 and GLUD2 glutamate dehydrogenases suggests novel functions (2017), Neurochem. Res., 42, 92-107 .
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Sf9 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
17beta-estradiol
-
Homo sapiens
corticosterone
-
Homo sapiens
dehydroepiandrosterone
-
Homo sapiens
dehydrotestosterone
-
Homo sapiens
diethylstilbestrol
-
Homo sapiens
estriol
-
Homo sapiens
pregnenolone
-
Homo sapiens
progesterone
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P00367
-
-
Homo sapiens P49448
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal dense expression of both isoforms Gdh1 and Gdh2 Homo sapiens
-
brain expression of both isoforms Gdh1 and Gdh2 Homo sapiens
-
kidney expression of both isoforms Gdh1 and Gdh2 Homo sapiens
-
liver high expression of isoform Gdh1 Homo sapiens
-
additional information no expression in hepaocyte Homo sapiens
-
additional information no expression in Sertoli cells Homo sapiens
-
ovary both hGDH1 and hGDH2 are densely expressed in estrogen producing cells Homo sapiens
-
placenta both hGDH1 and hGDH2 are densely expressed in estrogen producing cells Homo sapiens
-
Sertoli cell strong expression 0f isoform Gdh2 Homo sapiens
-
testis expression of both isoforms Gdh1 and Gdh2 Homo sapiens
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.001
-
pH 8.0, temperature not specified in the publication Homo sapiens corticosterone
0.001
-
presence of 0.1 M ADP, pH 8.0, temperature not specified in the publication Homo sapiens diethylstilbestrol
0.0015
-
pH 8.0, temperature not specified in the publication Homo sapiens 17beta-estradiol
0.00167
-
pH 8.0, temperature not specified in the publication Homo sapiens diethylstilbestrol
0.0021
-
pH 8.0, temperature not specified in the publication Homo sapiens corticosterone
0.0025
-
presence of 0.1 M ADP, pH 8.0, temperature not specified in the publication Homo sapiens corticosterone
0.0032
-
presence of 0.1 M ADP, pH 8.0, temperature not specified in the publication Homo sapiens corticosterone
0.0071
-
presence of 0.1 M ADP, pH 8.0, temperature not specified in the publication Homo sapiens diethylstilbestrol
0.0072
-
pH 8.0, temperature not specified in the publication Homo sapiens dehydroepiandrosterone
0.008
-
pH 8.0, temperature not specified in the publication Homo sapiens diethylstilbestrol
0.0113
-
pH 8.0, temperature not specified in the publication Homo sapiens estriol
0.0117
-
pH 8.0, temperature not specified in the publication Homo sapiens pregnenolone
0.0123
-
pH 8.0, temperature not specified in the publication Homo sapiens progesterone
0.0151
-
presence of 0.1 M ADP, pH 8.0, temperature not specified in the publication Homo sapiens 17beta-estradiol
0.0269
-
pH 8.0, temperature not specified in the publication Homo sapiens 17beta-estradiol
0.0294
-
presence of 0.1 M ADP, pH 8.0, temperature not specified in the publication Homo sapiens dehydroepiandrosterone
0.0494
-
pH 8.0, temperature not specified in the publication Homo sapiens dehydrotestosterone
0.0541
-
presence of 0.1 M ADP, pH 8.0, temperature not specified in the publication Homo sapiens pregnenolone
0.0589
-
presence of 0.1 M ADP, pH 8.0, temperature not specified in the publication Homo sapiens progesterone
0.0692
-
presence of 0.1 M ADP, pH 8.0, temperature not specified in the publication Homo sapiens 17beta-estradiol
0.0915
-
presence of 0.1 M ADP, pH 8.0, temperature not specified in the publication Homo sapiens dehydrotestosterone
0.104
-
pH 8.0, temperature not specified in the publication Homo sapiens pregnenolone
0.119
-
pH 8.0, temperature not specified in the publication Homo sapiens progesterone
0.145
-
pH 8.0, temperature not specified in the publication Homo sapiens estriol
0.189
-
presence of 0.1 M ADP, pH 8.0, temperature not specified in the publication Homo sapiens estriol
0.216
-
pH 8.0, temperature not specified in the publication Homo sapiens dehydroepiandrosterone
0.287
-
presence of 0.1 M ADP, pH 8.0, temperature not specified in the publication Homo sapiens pregnenolone
0.316
-
presence of 0.1 M ADP, pH 8.0, temperature not specified in the publication Homo sapiens estriol
0.396
-
presence of 0.1 M ADP, pH 8.0, temperature not specified in the publication Homo sapiens dehydroepiandrosterone
0.494
-
pH 8.0, temperature not specified in the publication Homo sapiens dehydrotestosterone
0.596
-
presence of 0.1 M ADP, pH 8.0, temperature not specified in the publication Homo sapiens progesterone
0.814
-
presence of 0.1 M ADP, pH 8.0, temperature not specified in the publication Homo sapiens dehydrotestosterone