KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.022 | - |
NADH | pH 9, 25°C | Streptomyces virginiae | |
0.022 | - |
NADH | pH 7, 25°C | Streptomyces virginiae | |
0.84 | - |
NAD+ | pH 8, 25°C | Streptomyces virginiae | |
0.84 | - |
NAD+ | pH 9, 25°C | Streptomyces virginiae | |
2.2 | - |
dihydroxyacetone | pH 9, 25°C | Streptomyces virginiae | |
2.2 | - |
dihydroxyacetone | pH 7, 25°C | Streptomyces virginiae | |
4 | - |
serinol | pH 8, 25°C | Streptomyces virginiae | |
4 | - |
serinol | pH 9, 25°C | Streptomyces virginiae | |
26.5 | - |
NH3 | pH 9, 25°C | Streptomyces virginiae | |
26.5 | - |
NH3 | pH 7, 25°C | Streptomyces virginiae |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
soluble | - |
Streptomyces virginiae | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
95000 | - |
gel filtration | Streptomyces virginiae |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptomyces virginiae | - |
- |
- |
Streptomyces virginiae IFO 12827 | - |
- |
- |
Purification (Comment) | Organism |
---|---|
from cell-free extract by sequential column chromatography | Streptomyces virginiae |
from the cell-free extract by sequential column chromatography | Streptomyces virginiae |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(R)-1-phenethylamine + H2O + NAD+ | - |
Streptomyces virginiae | acetophenone + NH3 + NADH + H+ | - |
r | |
(R)-1-phenethylamine + NAD+ + H2O | - |
Streptomyces virginiae | phenylacetaldehyde + NH3 + NADH + H+ | - |
r | |
(R)-1-phenethylamine + NAD+ + H2O | - |
Streptomyces virginiae IFO 12827 | phenylacetaldehyde + NH3 + NADH + H+ | - |
r | |
(R)-2-aminoheptane + NAD+ + H2O | - |
Streptomyces virginiae | 2-oxoheptane + NH3 + NADH + H+ | - |
r | |
(R)-2-aminoheptane + NAD+ + H2O | - |
Streptomyces virginiae IFO 12827 | 2-oxoheptane + NH3 + NADH + H+ | - |
r | |
(R)-2-butylamine + NAD+ + H2O | - |
Streptomyces virginiae | 2-oxobutane + NH3 + NADH + H+ | - |
r | |
(R)-2-butylamine + NAD+ + H2O | - |
Streptomyces virginiae IFO 12827 | 2-oxobutane + NH3 + NADH + H+ | - |
r | |
(R,S)-2-amino-1-pentanol + NAD+ + H2O | - |
Streptomyces virginiae | 2-oxo-pentan-1-ol + NH3 + NADH + H+ | - |
r | |
(R,S)-2-aminopentan-1-ol + H2O + NAD+ | - |
Streptomyces virginiae | 2-oxopentan-1-ol + NH3 + NADH + H+ | - |
r | |
(S)-1-phenethylamine + H2O + NAD+ | - |
Streptomyces virginiae | acetophenone + NH3 + NADH + H+ | - |
r | |
(S)-1-phenethylamine + NAD+ + H2O | - |
Streptomyces virginiae | phenylacetaldehyde + NH3 + NADH + H+ | - |
r | |
(S)-2-amino-1-butanol + NAD+ + H2O | - |
Streptomyces virginiae | 2-oxo-butan-1-ol + NH3 + NADH + H+ | - |
r | |
(S)-2-amino-3-methyl-1-butanol + NAD+ + H2O | - |
Streptomyces virginiae | 2-oxo-3-methylbutan-1-ol + NH3 + NADH + H+ | - |
r | |
(S)-2-amino-3-methylbutan-1-ol + H2O + NAD+ | - |
Streptomyces virginiae | 3-methyl-2-oxobutan-1-ol + NH3 + NADH + H+ | - |
r | |
(S)-2-aminobutan-1-ol + H2O + NAD+ | - |
Streptomyces virginiae | 2-oxobutan-1-ol + NH3 + NADH + H+ | - |
r | |
(S)-2-aminoheptane + NAD+ + H2O | - |
Streptomyces virginiae | 2-oxoheptane + NH3 + NADH + H+ | - |
r | |
(S)-2-butylamine + H2O + NAD+ | - |
Streptomyces virginiae | 2-oxobutane + NH3 + NADH + H+ | - |
r | |
(S)-2-butylamine + NAD+ + H2O | - |
Streptomyces virginiae | 2-oxobutane + NH3 + NADH + H+ | - |
r | |
(S)-isoleucinol + H2O + NAD+ | - |
Streptomyces virginiae | ? + NH3 + NADH + H+ | - |
r | |
(S)-isoleucinol + NAD+ + H2O | - |
Streptomyces virginiae | 2-oxo-3-methylpentan-1-ol + NH3 + NADH + H+ | - |
r | |
(S)-leucinol + H2O + NAD+ | - |
Streptomyces virginiae | ? + NH3 + NADH + H+ | - |
r | |
(S)-leucinol + NAD+ + H2O | - |
Streptomyces virginiae | 2-oxo-5-methylpentan-1-ol + NH3 + NADH + H+ | - |
r | |
(S)-methioninol + H2O + NAD+ | - |
Streptomyces virginiae | ? + NH3 + NADH + H+ | - |
r | |
(S)-methioninol + NAD+ + H2O | - |
Streptomyces virginiae | 2-oxo-3-methylpentan-1-ol + NH3 + NADH + H+ | - |
r | |
2-amino-1-propanol + H2O + NAD+ | - |
Streptomyces virginiae | 1-hydroxyacetone + NH3 + NADH + H+ | - |
r | |
2-aminocyclohexanol + NAD+ + H2O | - |
Streptomyces virginiae | 2-oxo-cyclohexanol + NH3 + NADH + H+ | - |
r | |
2-aminopentane + H2O + NAD+ | - |
Streptomyces virginiae | 2-oxopentane + NH3 + NADH + H+ | - |
r | |
2-aminopentane + NAD+ + H2O | - |
Streptomyces virginiae | 2-oxopentane + NH3 + NADH + H+ | - |
r | |
2-oxopropanoate + NH3 + NADH + H+ | - |
Streptomyces virginiae | D,L-alanine + H2O + NAD+ | - |
r | |
3-acetyl-1-propanol + NH3 + NADH + H+ | - |
Streptomyces virginiae | 3-aminobutan-1-ol + H2O + NAD+ | - |
r | |
3-aminopentane + H2O + NAD+ | - |
Streptomyces virginiae | 3-oxopentane + NH3 + NADH + H+ | - |
r | |
3-aminopentane + NAD+ + H2O | - |
Streptomyces virginiae | 3-oxopentane + NH3 + NADH + H+ | - |
r | |
3-hydroxy-2-butanone + NH3 + NADH + H+ | - |
Streptomyces virginiae | 3-amino-butan-2-ol + NAD+ + H2O | - |
r | |
3-hydroxy-2-butanone + NH3 + NADH + H+ | - |
Streptomyces virginiae | 3-aminobutan-2-ol + H2O + NAD+ | - |
r | |
4-hydroxy-2-butanone + NH3 + NADH + H+ | - |
Streptomyces virginiae | 3-amino-butan-1-ol + NAD+ + H2O | - |
r | |
4-hydroxy-2-butanone + NH3 + NADH + H+ | - |
Streptomyces virginiae | 3-aminobutan-1-ol + H2O + NAD+ | - |
r | |
4-hydroxyhexan-3-one + NH3 + NADH + H+ | - |
Streptomyces virginiae | 4-aminohexanan-3-ol + NAD+ + H2O | - |
r | |
4-phenylbutan-2-one + NH3 + NADH + H+ | - |
Streptomyces virginiae | 4-phenylbutan-2-amine + NAD+ + H2O | - |
r | |
5-hydroxyoctan-4-one + NH3 + NADH + H+ | - |
Streptomyces virginiae | 5-aminooctan-4-ol + NAD+ + H2O | - |
r | |
5-hydroxypentan-2-one + NH3 + NADH + H+ | - |
Streptomyces virginiae | 5-aminopentan-1-ol + H2O + NAD+ | - |
r | |
acetaldehyde + NH3 + NADH + H+ | - |
Streptomyces virginiae | ethylamine + NAD+ + H2O | - |
r | |
acetaldehyde + NH3 + NADH + H+ | - |
Streptomyces virginiae | ethylamine + H2O + NAD+ | - |
r | |
acetophenone + NH3 + NADH + H+ | - |
Streptomyces virginiae | 1-phenylethan-1-amine + NAD+ + H2O | - |
r | |
aspartate + H2O + NAD+ | - |
Streptomyces virginiae | ? + NH3 + NADH + H+ | - |
r | |
benzaldehyde + NH3 + NADH + H+ | - |
Streptomyces virginiae | benzylamine + H2O + NAD+ | - |
r | |
benzaldehyde + NH3 + NADH + H+ | - |
Streptomyces virginiae | benzylamine + NAD+ + H2O | - |
r | |
benzylamine + H2O + NAD+ | - |
Streptomyces virginiae | benzaldehyde + NH3 + NADH + H+ | - |
r | |
benzylamine + NAD+ + H2O | - |
Streptomyces virginiae | benzaldehyde + NH3 + NADH + H+ | - |
r | |
butan-2-one + NH3 + NADH + H+ | - |
Streptomyces virginiae | 2-aminobutane + NAD+ + H2O | - |
r | |
butan-2-one + NH3 + NADH + H+ | - |
Streptomyces virginiae | 2-aminobutane + H2O + NAD+ | - |
r | |
butanal + NH3 + NADH + H+ | - |
Streptomyces virginiae | n-butylamine + NAD+ + H2O | - |
r | |
butanal + NH3 + NADH + H+ | - |
Streptomyces virginiae | butylamine + H2O + NAD+ | - |
r | |
D-alanine + H2O + NAD+ | - |
Streptomyces virginiae | 2-oxopropanoate + NH3 + NADH + H+ | - |
r | |
D-alanine + NAD+ + H2O | - |
Streptomyces virginiae | 2-oxopropanoate + NH3 + NADH + H+ | - |
r | |
D-aspartate + H2O + NAD+ | - |
Streptomyces virginiae | 2-oxobutanedioate + NH3 + NADH + H+ | - |
r | |
D-glutamate + H2O + NAD+ | - |
Streptomyces virginiae | 2-oxopentanedioate + NH3 + NADH + H+ | - |
r | |
D-glutamate + NAD+ + H2O | - |
Streptomyces virginiae | 2-oxopentanedioic acid + NH3 + NADH + H+ | - |
r | |
D-serine + NAD+ + H2O | - |
Streptomyces virginiae | 3-hydroxy-2-oxopropanoate + NH3 + NADH + H+ | - |
r | |
dihydroxyacetone + NH3 + NADH + H+ | - |
Streptomyces virginiae | serinol + NAD+ + H2O | - |
r | |
dihydroxyacetone + NH3 + NADH + H+ | - |
Streptomyces virginiae | serinol + H2O + NAD+ | - |
? | |
ethylamine + NAD+ + H2O | - |
Streptomyces virginiae | acetaldehyde + NH3 + NADH + H+ | - |
r | |
hexan-2-one + NH3 + NADH + H+ | - |
Streptomyces virginiae | 2-aminohexane + NAD+ + H2O | - |
r | |
hexanal + NH3 + NADH + H+ | - |
Streptomyces virginiae | n-hexylamine + NAD+ + H2O | - |
r | |
hydroxyacetone + NH3 + NADH + H+ | - |
Streptomyces virginiae | 2-aminopropan-1-ol + NAD+ + H2O | - |
r | |
hydroxyacetone + NH3 + NADH + H+ | - |
Streptomyces virginiae | 1-aminopropanone + H2O + NAD+ | - |
r | |
L-alanine + H2O + NAD+ | - |
Streptomyces virginiae | 2-oxopropanoate + NH3 + NADH + H+ | - |
r | |
L-alanine + NAD+ + H2O | - |
Streptomyces virginiae | 2-oxopropanoate + NH3 + NADH + H+ | - |
r | |
L-aspartate + H2O + NAD+ | - |
Streptomyces virginiae | 2-oxobutanedioate + NH3 + NADH + H+ | - |
r | |
L-aspartate + NAD+ + H2O | - |
Streptomyces virginiae | 2-oxobutanedioic acid + NH3 + NADH + H+ | - |
r | |
L-glutamate + H2O + NAD+ | - |
Streptomyces virginiae | 2-oxopentanedioate + NH3 + NADH + H+ | - |
r | |
L-glutamate + NAD+ + H2O | - |
Streptomyces virginiae | 2-oxopentanedioic acid + NH3 + NADH + H+ | - |
r | |
L-serine + NAD+ + H2O | - |
Streptomyces virginiae | 2-oxopentanedioic acid + NH3 + NADH + H+ | - |
r | |
methylamin + NAD+ + H2O | - |
Streptomyces virginiae | formaldehyde + NH3 + NADH + H+ | - |
r | |
additional information | enzyme catalyzes the reversible oxidative deaminations of amines and also amino alcohols and amino acids | Streptomyces virginiae | ? | - |
- |
|
additional information | catalyzes the reversible oxidative deaminations of amines but also amino alcohols and amino acids | Streptomyces virginiae | ? | - |
- |
|
additional information | enzyme catalyzes the reversible oxidative deaminations of amines and also amino alcohols and amino acids | Streptomyces virginiae IFO 12827 | ? | - |
- |
|
additional information | catalyzes the reversible oxidative deaminations of amines but also amino alcohols and amino acids | Streptomyces virginiae IFO 12827 | ? | - |
- |
|
n-butylamine + NAD+ + H2O | - |
Streptomyces virginiae | butanal + NH3 + NADH + H+ | - |
r | |
n-hexylamine + NAD+ + H2O | - |
Streptomyces virginiae | hexanal + NH3 + NADH + H+ | - |
r | |
n-octylamine + NAD+ + H2O | - |
Streptomyces virginiae | octanal + NH3 + NADH + H+ | - |
r | |
n-propylamine + NAD+ + H2O | - |
Streptomyces virginiae | propanal + NH3 + NADH + H+ | - |
r | |
pentan-2-one + NH3 + NADH + H+ | - |
Streptomyces virginiae | 2-aminopentane + NAD+ + H2O | - |
r | |
pentan-2-one + NH3 + NADH + H+ | - |
Streptomyces virginiae | 2-aminopentane + H2O + NAD+ | - |
r | |
phenethylamine + H2O + NAD+ | - |
Streptomyces virginiae | acetophenone + NH3 + NADH + H+ | - |
r | |
propionaldehyde + NH3 + NADH + H+ | - |
Streptomyces virginiae | n-propylamine + NAD+ + H2O | - |
r | |
serinol + H2O + NAD+ | - |
Streptomyces virginiae | dihydroxyacetone + NH3 + NADH + H+ | - |
r | |
serinol + NAD+ + H2O | - |
Streptomyces virginiae | dihydroxyacetone + NH3 + NADH + H+ | - |
r |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 46000, SDS-PAGE | Streptomyces virginiae |
Synonyms | Comment | Organism |
---|---|---|
AMDH | - |
Streptomyces virginiae |
NAD+-dependent amine dehydrogenase | - |
Streptomyces virginiae |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
- |
Streptomyces virginiae |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
30 min, pH 7, 55% residual activity | Streptomyces virginiae |
30 | - |
30 min, 55% residual ativity | Streptomyces virginiae |
40 | - |
30 min, pH 7, 25% residual activity | Streptomyces virginiae |
40 | - |
30 min, 25% residual ativity | Streptomyces virginiae |
45 | - |
30 min, pH 7, 0% residual activity | Streptomyces virginiae |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.5 | 7 | amination reaction | Streptomyces virginiae |
6.5 | 7 | aminating reaction | Streptomyces virginiae |
10 | - |
deaminating reaction | Streptomyces virginiae |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
additional information | enzyme does not require artificial electron acceptors such as phenazine methosulfate | Streptomyces virginiae | |
NAD+ | enzyme is dependent on NAD+ or NADH | Streptomyces virginiae | |
NAD+ | dependent on NAD+ or NADH | Streptomyces virginiae | |
NADH | enzyme is dependent on NAD+ or NADH | Streptomyces virginiae | |
NADH | dependent on NAD+ or NADH | Streptomyces virginiae | |
NADP+ | substrate serinol, 13% of the activity with NAD+ | Streptomyces virginiae | |
NADP+ | about 13% of the activity with NAD+ | Streptomyces virginiae | |
NADPH | substrate dihydroxyacetone, 8.5% of the activity with NAD+ | Streptomyces virginiae | |
NADPH | about 8.5% of the activity with NADH | Streptomyces virginiae |