Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
General Information | Comment | Organism |
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physiological function | construction of a genome-scale model of human cell metabolism to investigate the potential metabolic alterations in cells using net zero ATP glycolysis. A pathway for ATP generation involves reactions from serine biosynthesis, one-carbon metabolism and the glycine cleavage system, and is transcriptionally upregulated in an inducible murine model of Myc-driven liver tumorigenesis. This pathway has a predicted two-fold higher flux rate in cells using net zero ATP glycolysis than those using standard glycolysis and generates twice as much ATP with significantly lower rate of lactate, but higher rate of alanine secretion | Homo sapiens |