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Literature summary for 1.4.1.27 extracted from

  • Tan, Y.; Sou, N.; Tang, F.; Ko, H.; Yeh, W.; Peng, J.; Chiang, E.
    Tracing metabolic fate of mitochondrial glycine cleavage system derived formate in vitro and in vivo (2020), Int. J. Mol. Sci., 21, 8808 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.4.1.27

Organism

Organism UniProt Comment Textmining
Homo sapiens P23378 and P23434 and P48728 and P09622 P23378 i.e. glycine dehydrogenase component P-protein, cf. EC 1.4.4.2, P23434 i.e. component H-protein, P48728 i.e. aminomethyltransferase component T-protein, cf. EC 2.1.2.10, P09622 i.e. dihydrolipoyl dehydrogenase component L-protein, cf. EC 1.8.1.4
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Mus musculus Q91W43 and O08749 Q91W43 i.e. glycine dehydrogenase component P-protein, cf. EC 1.4.4.2, O08749 i.e. dihydrolipoyl dehydrogenase component L-protein, cf. EC 1.8.1.4
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Source Tissue

Source Tissue Comment Organism Textmining
hepatoma cell
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 Homo sapiens
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hepatoma cell
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 Mus musculus
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General Information

General Information Comment Organism
metabolism isotopic labeling to explore the in vitro and in vivo metabolic fate of the 2-carbon from [2-13C]glycine and [2-13C]serine. As the 2-carbon of glycine and serine is decarboxylated and catabolized via the GCS, the original 13C-labeled 2-carbon is transferred to tetrahydrofolate and yields methylene-tetrahydrofolate in the mitochondria. In hepatoma cell-lines, 2-carbon from glycine is incorporated into deoxythymidine, species of purines (deoxyadenine and deoxyguanine), and methionine Homo sapiens
metabolism isotopic labeling to explore the in vitro and in vivo metabolic fate of the 2-carbon from [2-13C]glycine and [2-13C]serine. In healthy mice, incorporation of GCS-derived formate from glycine 2-carbon is found in serine, methionine, dTMP, and methylcytosine in bone marrow DNA. Labeled glycine 2-carbon directly incorporates into serine, adenine and guanine (at C2 and C8 of purine) in the cytosol Mus musculus