BRENDA - Enzyme Database show
show all sequences of 1.4.1.1

Partial purification and properties of Halobacterium cutirubrum L-alanine dehydrogenase

Kim, E.K.; Fitt, P.S.; Biochem. J. 161, 313-320 (1977)

Data extracted from this reference:

General Stability
General Stability
Organism
absolute requirement of high ionic strength for stability
Halobacterium salinarum
Inhibitors
Inhibitors
Commentary
Organism
Structure
Cd2+
10 mM, 36% inhibition of reductive amination
Halobacterium salinarum
Co2+
10 mM, 60% inhibition of reductive amination
Halobacterium salinarum
Cu2+
10 mM, 60% inhibition of reductive amination
Halobacterium salinarum
D-2-aminobutanoate
-
Halobacterium salinarum
D-Ala
-
Halobacterium salinarum
Fe2+
10 mM, 85% inhibition of reductive amination
Halobacterium salinarum
Fe3+
10 mM, 85% inhibition of reductive amination
Halobacterium salinarum
Mn2+
10 mM, 60% inhibition of reductive amination
Halobacterium salinarum
Ni2+
10 mM, 60% inhibition of reductive amination
Halobacterium salinarum
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.2
-
NADH
-
Halobacterium salinarum
0.5
-
NAD+
-
Halobacterium salinarum
0.8
-
pyruvate
-
Halobacterium salinarum
7
-
L-Ala
-
Halobacterium salinarum
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Cs+
reductive amination is activated equally well by K+, Na+ or NH4+ and to a lesser extent with Cs+ or Li+
Halobacterium salinarum
KCl
reductive amination is activated equally well by K+, Na+ or NH4+ and to a lesser extent with Cs+ or Li+, absolute requirement for K+ in oxidative deamination, completely inactive with Na+ or NH4+
Halobacterium salinarum
Li+
reductive amination is activated equally well by K+, Na+ or NH4+ and to a lesser extent with Cs+ or Li+
Halobacterium salinarum
additional information
absolute requirement for high ionic strength for optimum activity
Halobacterium salinarum
NaCl
reductive amination is activated equally well by K+, Na+ or NH4+ and to a lesser extent with Cs+ or Li+
Halobacterium salinarum
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
72500
-
-
Halobacterium salinarum
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Halobacterium salinarum
-
-
-
Purification (Commentary)
Commentary
Organism
partial
Halobacterium salinarum
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
168
-
-
Halobacterium salinarum
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2-oxoglutarate + NH3 + NADH
no activity
349573
Halobacterium salinarum
L-Gln + NAD+ + H2O
-
-
-
-
4-methyl-2-oxopentanoate + NH3 + NADH
-
349573
Halobacterium salinarum
2-amino-4-methylpentanoate + NAD+ + H2O
-
-
-
?
glyoxylate + NH3 + NADH
-
349573
Halobacterium salinarum
aminoacetate + NAD+ + H2O
-
-
-
?
L-2-aminobutanoate + H2O + NAD+
-
349573
Halobacterium salinarum
2-oxobutanoate + NH3 + NADH
-
349573
Halobacterium salinarum
r
L-Ala + H2O + NAD+
-
349573
Halobacterium salinarum
pyruvate + NH3 + NADH
-
349573
Halobacterium salinarum
r
oxaloacetate + NH3 + NADH
-
349573
Halobacterium salinarum
L-Asp + H2O + NAD+
-
-
-
?
Subunits
Subunits
Commentary
Organism
hexamer
-
Halobacterium salinarum
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
60
65
reductive amination, in presence of KCl
Halobacterium salinarum
65
70
reductive amination in presence of NaCl
Halobacterium salinarum
Temperature Range [°C]
Temperature Minimum [°C]
Temperature Maximum [°C]
Commentary
Organism
40
65
40°C: about 50% of activity maximum, 65°C: optimum, sharp decrease of activity above, no activity at 75°C
Halobacterium salinarum
Temperature Stability [°C]
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
55
-
pH 8.5, 50 min, 40% loss of activity
Halobacterium salinarum
60
-
pH 8.5, 10 min, about 45% loss of activity
Halobacterium salinarum
70
-
pH 8.5, 10 min, 90% loss of activity
Halobacterium salinarum
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
9
-
both directions
Halobacterium salinarum
Cofactor
Cofactor
Commentary
Organism
Structure
NAD+
-
Halobacterium salinarum
NADH
-
Halobacterium salinarum
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NAD+
-
Halobacterium salinarum
NADH
-
Halobacterium salinarum
General Stability (protein specific)
General Stability
Organism
absolute requirement of high ionic strength for stability
Halobacterium salinarum
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
Cd2+
10 mM, 36% inhibition of reductive amination
Halobacterium salinarum
Co2+
10 mM, 60% inhibition of reductive amination
Halobacterium salinarum
Cu2+
10 mM, 60% inhibition of reductive amination
Halobacterium salinarum
D-2-aminobutanoate
-
Halobacterium salinarum
D-Ala
-
Halobacterium salinarum
Fe2+
10 mM, 85% inhibition of reductive amination
Halobacterium salinarum
Fe3+
10 mM, 85% inhibition of reductive amination
Halobacterium salinarum
Mn2+
10 mM, 60% inhibition of reductive amination
Halobacterium salinarum
Ni2+
10 mM, 60% inhibition of reductive amination
Halobacterium salinarum
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.2
-
NADH
-
Halobacterium salinarum
0.5
-
NAD+
-
Halobacterium salinarum
0.8
-
pyruvate
-
Halobacterium salinarum
7
-
L-Ala
-
Halobacterium salinarum
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Cs+
reductive amination is activated equally well by K+, Na+ or NH4+ and to a lesser extent with Cs+ or Li+
Halobacterium salinarum
KCl
reductive amination is activated equally well by K+, Na+ or NH4+ and to a lesser extent with Cs+ or Li+, absolute requirement for K+ in oxidative deamination, completely inactive with Na+ or NH4+
Halobacterium salinarum
Li+
reductive amination is activated equally well by K+, Na+ or NH4+ and to a lesser extent with Cs+ or Li+
Halobacterium salinarum
additional information
absolute requirement for high ionic strength for optimum activity
Halobacterium salinarum
NaCl
reductive amination is activated equally well by K+, Na+ or NH4+ and to a lesser extent with Cs+ or Li+
Halobacterium salinarum
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
72500
-
-
Halobacterium salinarum
Purification (Commentary) (protein specific)
Commentary
Organism
partial
Halobacterium salinarum
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
168
-
-
Halobacterium salinarum
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2-oxoglutarate + NH3 + NADH
no activity
349573
Halobacterium salinarum
L-Gln + NAD+ + H2O
-
-
-
-
4-methyl-2-oxopentanoate + NH3 + NADH
-
349573
Halobacterium salinarum
2-amino-4-methylpentanoate + NAD+ + H2O
-
-
-
?
glyoxylate + NH3 + NADH
-
349573
Halobacterium salinarum
aminoacetate + NAD+ + H2O
-
-
-
?
L-2-aminobutanoate + H2O + NAD+
-
349573
Halobacterium salinarum
2-oxobutanoate + NH3 + NADH
-
349573
Halobacterium salinarum
r
L-Ala + H2O + NAD+
-
349573
Halobacterium salinarum
pyruvate + NH3 + NADH
-
349573
Halobacterium salinarum
r
oxaloacetate + NH3 + NADH
-
349573
Halobacterium salinarum
L-Asp + H2O + NAD+
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
hexamer
-
Halobacterium salinarum
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
60
65
reductive amination, in presence of KCl
Halobacterium salinarum
65
70
reductive amination in presence of NaCl
Halobacterium salinarum
Temperature Range [°C] (protein specific)
Temperature Minimum [°C]
Temperature Maximum [°C]
Commentary
Organism
40
65
40°C: about 50% of activity maximum, 65°C: optimum, sharp decrease of activity above, no activity at 75°C
Halobacterium salinarum
Temperature Stability [°C] (protein specific)
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
55
-
pH 8.5, 50 min, 40% loss of activity
Halobacterium salinarum
60
-
pH 8.5, 10 min, about 45% loss of activity
Halobacterium salinarum
70
-
pH 8.5, 10 min, 90% loss of activity
Halobacterium salinarum
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
9
-
both directions
Halobacterium salinarum
Other publictions for EC 1.4.1.1
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
741751
Szymanska-Majchrzak
Isotopic effects in mechanist ...
Bacillus subtilis
Appl. Radiat. Isot.
123
21-25
2017
-
-
-
-
-
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-
-
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1
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1
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2
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1
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2
-
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-
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-
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-
-
-
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-
742071
Reshma
Design and development of new ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Bioorg. Med. Chem.
24
4499-4508
2016
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-
1
1
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-
2
-
-
-
-
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-
9
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-
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2
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1
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1
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2
2
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742134
Lerchner
Engineering of alanine dehydr ...
Bacillus subtilis
Biotechnol. Appl. Biochem.
63
616-624
2016
-
1
1
-
4
-
-
8
-
-
-
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4
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2
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8
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2
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1
1
2
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4
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8
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-
-
-
-
-
-
2
-
-
-
-
8
-
-
-
-
-
-
-
-
8
8
743605
Giffin
Role of alanine dehydrogenase ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
PLoS ONE
11
e0155522
2016
-
-
-
-
-
-
-
-
-
-
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-
-
10
-
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1
1
1
1
-
-
742450
Saxena
Design and development of nov ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Eur. J. Med. Chem.
92
401-414
2015
-
-
-
-
-
-
4
2
-
-
-
-
-
9
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
4
4
-
2
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
742705
Li
Domain motions and functional ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Int. J. Mol. Sci.
16
29383-29397
2015
-
-
-
1
-
-
-
-
-
-
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9
-
-
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-
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1
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743722
Fernandes
Alteration of substrate speci ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Protein Eng. Des. Sel.
28
29-35
2015
-
-
1
-
2
-
-
2
-
-
-
-
-
9
-
-
-
-
-
-
-
-
15
-
-
-
-
2
-
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1
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2
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2
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-
15
-
-
-
-
2
-
-
-
-
-
-
-
-
20
20
743120
Ling
Molecular dynamics simulation ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
J. Mol. Graph. Model.
50
61-70
2014
-
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3
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9
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3
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-
723883
Lu
Crystallization and preliminar ...
Bacillus megaterium, Bacillus megaterium WSH-002
Acta Crystallogr. Sect. F
69
934-936
2013
-
-
1
1
-
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1
2
-
4
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1
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2
1
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2
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1
2
1
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1
2
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1
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2
1
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741520
Wen
Crystallization and prelimina ...
Bacillus pseudofirmus, Bacillus pseudofirmus OF4
Acta Crystallogr. Sect. F
69
1227-1230
2013
-
-
1
1
-
-
-
-
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1
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3
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1
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1
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1
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1
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1
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742778
Jeong
Regulation of the ald gene en ...
Mycolicibacterium smegmatis
J. Bacteriol.
195
3610-3620
2013
-
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2
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1
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1
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743765
Zech
Dynamics of amino acid utiliz ...
Phaeobacter inhibens, Phaeobacter inhibens DSM 17395
Proteomics
13
2869-2885
2013
-
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3
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1
1
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725267
Giffin
ald of Mycobacterium tuberculo ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
J. Bacteriol.
194
1045-1054
2012
-
-
1
-
1
-
-
6
3
-
-
6
-
162
-
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1
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1
-
6
-
1
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1
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2
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1
2
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1
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6
3
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6
-
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1
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1
-
6
-
1
-
-
-
1
-
-
-
1
2
2
1
-
-
724147
Al-Onazi
-
Isolation and characterization ...
Thielaviopsis paradoxa
Asian J. Appl. Sci.
4
702-711
2011
2
-
-
-
-
-
3
5
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-
7
-
1
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1
-
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7
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1
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2
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2
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2
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2
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3
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5
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7
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1
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7
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1
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2
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1
1
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712264
Nakane
-
Coimmobilization of malic enzy ...
Geobacillus stearothermophilus
J. Appl. Polym. Sci.
116
2901-2905
2010
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1
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1
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1
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1
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1
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1
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1
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1
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2
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1
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1
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1
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1
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1
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1
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1
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712305
Pernil
Catabolic function of compartm ...
Anabaena sp., Anabaena sp. PCC 7120
J. Bacteriol.
192
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Heterologous expression of the ...
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Production of L-alanine by met ...
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Contribution of L-alanine dehy ...
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2006
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655891
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Markerless mutagenesis in Meth ...
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Schröder
A novel archaeal alanine dehyd ...
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655888
Lodwig
Regulation of L-alanine dehydr ...
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656546
Gallagher
Structure of alanine dehydroge ...
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2004
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656576
Ashida
-
Conversion of cofactor specifi ...
Phormidium lapideum, Phormidium lapideum Ac10, Shewanella sp., Shewanella sp. Ac10
J. Mol. Catal. B
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173-176
2004
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6
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14
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6
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13
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654082
Smith
Crystallization and phasing of ...
Archaeoglobus fulgidus
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2328-2331
2003
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655519
Irwin
Alanine dehydrogenase from the ...
Shewanella sp., Shewanella sp. PA-43
Extremophiles
7
135-143
2003
1
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1
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5
18
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2
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7
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1
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2
1
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1
21
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1
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1
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1
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5
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18
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2
2
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1
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2
1
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1
21
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1
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656474
Bae
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Purification and biochemical c ...
Thermus caldophilus, Thermus caldophilus GK24
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628-631
2003
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2
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1
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656570
Kato
-
Purification and characterizat ...
Vibrio proteolyticus
J. Mol. Catal. B
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373-378
2003
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1
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2
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2
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1
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8
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1
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1
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3
1
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3
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2
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1
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349591
Feng
Mycobacterium smegmatis L-Alan ...
Mycolicibacterium smegmatis
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5001-5010
2002
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2
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2
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1
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2
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349592
Vadas
Room-temperature synthesis of ...
Archaeoglobus fulgidus
Biotechnol. Prog.
18
909-911
2002
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1
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1
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1
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2
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1
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2
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1
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1
1
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349594
Usha
Glycine and alanine dehydrogen ...
Mycolicibacterium smegmatis
Can. J. Microbiol.
48
7-13
2002
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2
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1
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2
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657148
Baysal
Screening and simple purificat ...
Bacillus megaterium, Bacillus megaterium LA 199
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32
277-285
2002
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1
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349584
Irwin
Characterization of alanine an ...
Bacteria, Phormidium lapideum, Shewanella sp., Vibrio proteolyticus
Extremophiles
5
199-211
2001
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1
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1
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4
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1
7
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8
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1
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4
3
1
1
7
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349581
Laue
Purification, properties and p ...
Bilophila wadsworthia
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1
1
13
1
2
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2
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2
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349583
Allaway
Identification of alanine dehy ...
Rhizobium leguminosarum
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2000
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Hutter
Properties of the 40 kDa antig ...
Mycobacterium tuberculosis
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349593
Galkin
Cold-adapted alanine dehydroge ...
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10
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8
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1
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1
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7
3
-
-
8
3
-
-
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349582
Hutter
Host vector system for high-le ...
Mycobacterium tuberculosis
Gene
212
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1998
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1
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1
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349589
Sedelnikova
Crystallization of the alanine ...
Phormidium lapideum
Acta Crystallogr. Sect. D
54
407-408
1998
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1
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1
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349590
Kim
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Unusual allosteric property of ...
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J. Biochem. Mol. Biol.
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1
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349595
Chowdhury
Alanine dehydrogenase from Ent ...
Klebsiella aerogenes
Biosci. Biotechnol. Biochem.
62
2357-2363
1998
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1
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4
4
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1
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1
1
11
1
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2
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2
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1
6
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1
6
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4
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4
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3
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1
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1
1
11
1
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-
2
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2
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1
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-
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349587
Delforge
Identification of lysine 74 in ...
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1997
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1
-
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349563
Sawa
Purification and characterizat ...
Bacillus subtilis, Phormidium lapideum
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1994
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2
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1
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14
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5
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1
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5
2
1
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2
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2
2
1
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-
-
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349599
Brunhuber
The biochemistry and enzymolog ...
Anabaena cylindrica, Bacillus cereus, Bacillus japonicum, Bacillus licheniformis, Bacillus subtilis, Geobacillus stearothermophilus, Halobacterium salinarum, Kitasatospora aureofaciens, Lysinibacillus sphaericus, Mycobacterium tuberculosis, Pseudomonas sp., Thermus thermophilus
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19
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8
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42
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1
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12
-
-
-
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19
-
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349586
Smith
Alanine dehydrogenase from soy ...
Rhizobium sp.
Arch. Biochem. Biophys.
304
379-385
1993
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5
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1
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1
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1
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3
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2
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7
3
5
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1
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1
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-
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349597
Siranosian
Alanine dehydrogenase (ald) is ...
Bacillus subtilis
J. Bacteriol.
175
6789-6796
1993
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2
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Sakamoto
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Gene cloning, purification and ...
Geobacillus stearothermophilus
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1
1
10
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3
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2
2
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349537
Ohshima
Thermostable alanine dehydroge ...
Lysinibacillus sphaericus
Eur. J. Biochem.
191
715-720
1990
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6
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2
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6
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1
1
6
1
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3
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1
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349538
Glasfeld
The stereospecificities of sev ...
Acholeplasma laidlawii
J. Biol. Chem.
265
11692-11699
1990
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1
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349539
Honorat
-
Synthesis of L-alanine and L-v ...
Bacillus megaterium
Enzyme Microb. Technol.
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515-520
1990
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3
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8
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1
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349540
Schultz
Enzymes of ammonia assimilatio ...
Frankia sp.
J. Bacteriol.
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1990
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2
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349543
Kuroda
Alanine dehydrogenases from tw ...
Geobacillus stearothermophilus, Lysinibacillus sphaericus
Biochemistry
29
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1990
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2
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349541
El-Awamry
Partial purification and prope ...
Cunninghamella elegans
Zentralbl. Mikrobiol.
144
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1989
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3
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2
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2
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2
1
1
1
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1
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2
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349542
Flores
-
Ammonium-assimilating enzymes ...
Saccharopolyspora erythraea
J. Gen. Appl. Microbiol.
35
203-211
1989
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349544
Ohshima
Continous production of 3-fluo ...
Lysinibacillus sphaericus
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394-397
1989
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Caballero
Purification and properties of ...
Rhodobacter capsulatus
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1989
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Vancurova
A further characterization of ...
Kitasatospora aureofaciens
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1989
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7
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7
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349547
Vancura
Alanine dehydrogenase from Str ...
Streptomyces fradiae
Eur. J. Biochem.
179
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1989
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7
7
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2
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6
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7
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7
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1
2
7
1
1
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2
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349596
Hutter B; Dick T
Increased alanine dehydrogenas ...
Mycolicibacterium smegmatis
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167
7-11
1989
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2
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Vancurova
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Purification and partial chara ...
Kitasatospora aureofaciens
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1988
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3
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5
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1
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1
1
1
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2
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349549
Weiss
Use of primary deuterium and 1 ...
Bacillus subtilis
Biochemistry
27
4814-4822
1988
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2
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1
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Crow
Properties of alanine dehydrog ...
Propionibacterium freudenreichii
Appl. Environ. Microbiol.
53
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1987
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2
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2
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1
1
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349551
Bellion
An NAD+-dependent alanine dehy ...
Pseudomonas sp., Pseudomonas sp. MA
Biochem. J.
244
565-570
1987
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1
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4
1
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349552
Porumb
Structural and catalytic prope ...
Bacillus cereus
J. Biol. Chem.
262
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1987
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1
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2
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2
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2
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1
1
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1
1
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2
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349553
Stams
-
Metabolism of L-alanine in Des ...
Desulfotomaculum ruminis, Desulfovibrio sp.
Arch. Microbiol.
145
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1986
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4
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2
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349554
Ohshima
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Screening of thermostable leuc ...
Bacillus coagulans, Bacillus sp. (in: Bacteria), Geobacillus stearothermophilus, Lysinibacillus sphaericus
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871-876
1985
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9
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8
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4
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9
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349556
Itoh
-
Crystallization and properties ...
Bacillus subtilis, Kitasatospora albolonga, Lysinibacillus sphaericus, Micromonospora melanosporea, Streptomyces albus, Streptomyces aureus, Streptomyces bobili, Streptomyces caespitosus, Streptomyces clavuligerus, Streptomyces coelicolor, Streptomyces flaveus, Streptomyces griseoluteus, Streptomyces griseus, Streptomyces hygroscopicus, Streptomyces lydicus, Streptomyces olivochromogenes, Streptomyces phaeochromogenes, Streptomyces roseochromogenes, Streptomyces roseus, Streptomyces ruber
Agric. Biol. Chem.
47
2511-2519
1983
6
-
-
1
-
-
12
7
-
-
2
-
-
20
-
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1
-
-
-
1
-
36
3
1
-
7
-
2
-
1
42
-
-
-
6
-
-
42
1
-
-
-
12
-
7
-
-
2
-
-
-
-
1
-
-
1
-
36
3
1
-
7
-
2
-
1
-
-
-
-
-
-
-
349557
Bellion
-
Nitrogen assimilation in facul ...
Pseudomonas sp., Pseudomonas sp. AM1, Pseudomonas sp. MA
Curr. Microbiol.
9
37-44
1983
-
-
-
-
-
-
-
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16
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3
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2
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2
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-
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3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
349558
Lauwers
Thermal properties of enzymes ...
Anoxybacillus flavithermus, Bacillus caldolyticus
Antonie van Leeuwenhoek
49
191-201
1983
-
-
-
-
-
-
-
-
-
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2
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2
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3
1
3
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4
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4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
3
1
3
-
-
-
-
-
-
-
-
-
-
-
349565
Muresan
Catalytic properties of Sephar ...
Bacillus cereus
Biochim. Biophys. Acta
742
617-622
1983
-
-
-
-
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1
-
10
-
-
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2
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1
-
-
-
-
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1
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5
-
2
-
1
2
-
-
-
-
-
-
2
-
-
1
-
-
-
10
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
5
-
2
-
1
-
-
-
-
-
-
-
349566
Mueller
-
Alanine dehydrogenase from bac ...
Anabaena cylindrica, Bradyrhizobium japonicum
Z. Naturforsch. C
37
927-936
1982
-
-
-
-
-
-
8
2
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-
2
1
-
2
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1
-
-
3
1
-
5
1
-
-
-
-
2
-
-
4
-
-
-
-
-
-
4
-
-
-
-
8
-
2
-
-
2
1
-
-
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1
-
3
1
-
5
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
349567
Tolxdorff-Neutzling
-
Metabolic role and regulation ...
Rhodobacter capsulatus
FEMS Microbiol. Lett.
13
155-159
1982
1
-
-
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9
5
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1
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1
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1
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2
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2
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2
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1
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2
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9
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5
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1
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1
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2
-
-
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-
2
-
-
-
-
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-
-
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-
349559
Grimshaw
Kinetic mechanism of Bacillus ...
Bacillus subtilis
Biochemistry
20
5650-5655
1981
-
-
-
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2
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1
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1
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2
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2
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
349560
Grimshaw
Use of isotope effects and pH ...
Bacillus subtilis
Biochemistry
20
5655-5661
1981
-
-
-
-
-
-
-
-
-
-
-
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2
-
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1
-
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1
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-
-
-
-
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2
-
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-
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2
-
-
-
-
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-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
349568
Vali
L-Alanine dehydrogenase from T ...
Bacillus subtilis, Thermus thermophilus
Biochim. Biophys. Acta
615
34-47
1980
-
-
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1
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5
11
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2
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4
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1
-
-
-
-
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8
2
-
-
2
-
4
-
-
4
4
-
-
-
-
-
4
1
-
-
-
5
4
11
-
-
2
-
-
-
-
1
-
-
-
-
8
2
-
-
2
-
4
-
-
-
-
-
-
-
-
-
349569
Keradjopoulos
Salt-dependent conformational ...
Halobacterium salinarum
FEBS Lett.
112
183-185
1980
-
-
-
-
-
2
-
-
-
-
-
-
-
2
-
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1
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1
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2
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2
-
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2
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-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
349570
Aharonowitz
Alanine dehydrogenase of the b ...
Streptomyces clavuligerus
Arch. Microbiol.
125
137-142
1980
-
-
-
-
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1
13
5
-
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1
-
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2
-
-
1
-
-
-
-
1
6
-
-
-
-
-
1
-
-
3
3
-
-
-
-
-
3
-
-
1
-
13
3
5
-
-
1
-
-
-
-
1
-
-
-
1
6
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
349571
Keradjopoulos
Purification and properties of ...
Halobacterium salinarum
Biochim. Biophys. Acta
570
1-10
1979
-
-
-
-
-
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4
-
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7
2
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2
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1
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1
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6
1
3
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1
-
1
-
-
2
-
-
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-
-
-
2
-
-
-
-
4
-
-
-
7
2
-
-
-
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1
-
-
1
-
6
1
3
-
1
-
1
-
-
-
-
-
-
-
-
-
349572
Ohashima
Purification and properties of ...
Lysinibacillus sphaericus
Eur. J. Biochem.
100
29-39
1979
-
-
-
1
-
-
4
11
-
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2
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3
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1
1
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1
1
8
-
1
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2
-
3
-
1
2
-
-
-
-
-
-
2
1
-
-
-
4
-
11
-
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2
-
-
-
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1
-
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1
1
8
-
1
-
2
-
3
-
1
-
-
-
-
-
-
-
349573
Kim
Partial purification and prope ...
Halobacterium salinarum
Biochem. J.
161
313-320
1977
-
-
-
-
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1
9
4
-
5
1
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2
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1
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1
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6
1
2
1
3
-
1
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2
-
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-
-
-
2
-
-
1
-
9
-
4
-
5
1
-
-
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1
-
-
1
-
6
1
2
1
3
-
1
-
-
-
-
-
-
-
-
-
349580
Keradjopoulos
-
Thermophilic character of enzy ...
Bacillus cereus, Bacillus cereus T, Bacillus subtilis, Halobacterium salinarum
FEMS Microbiol. Lett.
1
179-182
1977
-
-
-
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2
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1
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10
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-
-
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4
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1
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-
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2
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6
-
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-
6
-
-
-
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2
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-
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1
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-
-
-
-
-
-
-
-
-
4
-
1
-
-
-
2
-
-
-
-
-
-
-
-
-
349574
Rowell
Alanine dehydrogenase of the N ...
Anabaena cylindrica
Arch. Microbiol.
107
115-124
1976
-
-
-
-
-
-
7
3
-
-
2
-
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2
-
-
1
-
-
2
1
-
3
1
-
-
-
-
2
2
-
2
-
-
-
-
-
-
2
-
-
-
-
7
-
3
-
-
2
-
-
-
-
1
-
2
1
-
3
1
-
-
-
-
2
2
-
-
-
-
-
-
-
-
349562
Alizade
Stereochemistry of the hydroge ...
Bacillus subtilis
Biochim. Biophys. Acta
397
5-8
1975
-
-
-
-
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-
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2
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-
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-
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2
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2
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2
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-
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-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
12940
Nitta
L-Amino acid dehydrogenases in ...
Bacillus subtilis
J. Bacteriol.
117
588-592
1974
-
-
-
-
-
-
1
2
-
-
1
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1
-
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1
-
-
1
-
-
1
1
-
-
1
-
1
-
-
2
-
-
-
-
-
-
2
-
-
-
-
1
-
2
-
-
1
-
-
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-
1
-
1
-
-
1
1
-
-
1
-
1
-
-
-
-
-
-
-
-
-
349576
Keradjopoulos
Thermophilic alanine dehydroge ...
Halobacterium salinarum
Can. J. Biochem.
52
1033-1037
1974
-
-
-
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1
-
-
-
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2
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1
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3
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-
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2
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-
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-
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2
-
-
1
-
-
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-
-
-
-
-
-
-
-
-
-
1
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
349577
McCowen
Regulation of alanine dehydrog ...
Bacillus licheniformis
J. Bacteriol.
118
590-597
1974
-
-
-
-
-
-
3
-
-
-
-
-
-
2
-
-
1
-
-
-
1
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
2
-
-
-
-
3
-
-
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
349578
Graefe
Activity of alanine dehydrogen ...
Streptomyces hygroscopicus
Z. Allg. Mikrobiol.
14
181-192
1974
-
-
-
-
-
-
-
-
-
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1
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2
-
-
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-
-
1
-
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2
-
-
-
-
-
-
-
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2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
349585
Williamson
-
L-Alanin ...
Bacillus subtilis
Methods Enzym. Anal. , 3rd Ed. (Bergmeyer, H. U. , ed. )
2
1724-1727
1974
-
1
-
-
-
-
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1
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-
-
-
-
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1
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-
-
-
-
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2
-
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-
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1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
349564
Sulzman
Characterization of circadian ...
Euglena gracilis, Euglena gracilis Z
Biochim. Biophys. Acta
320
594-609
1973
-
-
-
-
-
-
-
-
-
-
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2
-
22
-
-
1
-
-
1
-
-
4
-
-
-
-
-
1
1
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
2
-
-
-
1
-
1
-
-
4
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
349579
Borris
Relationship of L-alanine and ...
Bacillus thuringiensis
Biochim. Biophys. Acta
191
716-718
1969
-
-
-
-
-
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1
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1
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-
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1
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2
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-
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2
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1
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-
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-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
349561
Germano
Purification and properties of ...
Desulfovibrio desulfuricans
J. Bacteriol.
96
55-60
1968
-
-
-
-
-
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1
3
-
-
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2
-
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1
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-
1
-
1
-
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-
-
-
1
-
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2
-
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-
-
-
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2
-
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1
-
3
-
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-
-
-
-
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1
-
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1
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
349598
Berberich
-
D-Amino acids as inducers of L ...
Bacillus subtilis
J. Biol. Chem.
243
1008-1013
1968
-
-
-
-
-
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1
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1
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2
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-
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2
-
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2
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1
-
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-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
349555
Yoshida
Enzymic properties of Alanine ...
Bacillus subtilis
Biochim. Biophys. Acta
96
248-262
1965
-
-
-
-
-
1
9
18
-
-
1
-
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2
-
-
1
-
-
-
1
1
9
-
-
-
-
1
2
2
2
2
-
-
-
-
-
-
2
-
-
1
-
9
-
18
-
-
1
-
-
-
-
1
-
-
1
1
9
-
-
-
-
1
2
2
2
-
-
-
-
-
-
-