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Crystallization and properties of L-alanine dehydrogenase from Streptomyces phaeochromogenes

Itoh, N.; Morikawa, R.; Itoh, N.; Morikawa, R.; Agric. Biol. Chem. 47, 2511-2519 (1983)
No PubMed abstract available

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
1,10-phenanthroline
activation
Streptomyces phaeochromogenes
2,2'-dipyridyl
activation
Streptomyces phaeochromogenes
2-mercaptoethanol
activation
Streptomyces phaeochromogenes
diethyldithiocarbamate
activation
Streptomyces phaeochromogenes
dithiothreitol
activation
Streptomyces phaeochromogenes
EDTA
activation
Streptomyces phaeochromogenes
Crystallization (Commentary)
Crystallization
Organism
-
Streptomyces phaeochromogenes
Inhibitors
Inhibitors
Commentary
Organism
Structure
Cu2+
-
Streptomyces phaeochromogenes
Cu2+
-
Streptomyces clavuligerus
Cu2+
-
Lysinibacillus sphaericus
monoiodoacetate
-
Streptomyces phaeochromogenes
Pb2+
-
Streptomyces phaeochromogenes
Pb2+
-
Lysinibacillus sphaericus
PCMB
-
Streptomyces phaeochromogenes
PCMB
-
Lysinibacillus sphaericus
PCMB
-
Bacillus subtilis
Zn2+
-
Streptomyces phaeochromogenes
Zn2+
-
Bacillus subtilis
Zn2+
-
Streptomyces clavuligerus
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.036
-
NAD+
pH 10.0
Streptomyces phaeochromogenes
0.047
-
NADH
-
Streptomyces phaeochromogenes
0.29
-
pyruvate
-
Streptomyces phaeochromogenes
1.9
-
L-Ala
pH 8.0
Streptomyces phaeochromogenes
3.6
-
L-Ala
pH 9.0
Streptomyces phaeochromogenes
7.1
-
L-Ala
pH 10.0
Streptomyces phaeochromogenes
61
-
NH4+
-
Streptomyces phaeochromogenes
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
39000
-
6 * 39000, SDS-PAGE
Streptomyces phaeochromogenes
240000
-
gel filtration
Streptomyces phaeochromogenes
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Bacillus subtilis
-
-
-
Kitasatospora albolonga
-
-
-
Lysinibacillus sphaericus
-
-
-
Micromonospora melanosporea
-
-
-
Streptomyces albus
-
-
-
Streptomyces aureus
-
-
-
Streptomyces bobili
-
-
-
Streptomyces caespitosus
-
-
-
Streptomyces clavuligerus
-
-
-
Streptomyces coelicolor
-
-
-
Streptomyces flaveus
-
-
-
Streptomyces griseoluteus
-
-
-
Streptomyces griseus
-
-
-
Streptomyces hygroscopicus
-
-
-
Streptomyces lydicus
-
-
-
Streptomyces olivochromogenes
-
-
-
Streptomyces phaeochromogenes
-
-
-
Streptomyces roseochromogenes
-
-
-
Streptomyces roseus
-
-
-
Streptomyces ruber
-
-
-
Purification (Commentary)
Commentary
Organism
-
Streptomyces phaeochromogenes
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
22.8
-
-
Streptomyces phaeochromogenes
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2-oxobutanoate + NH3 + NADH
-
349556
Lysinibacillus sphaericus
2-aminobutanoate + H2O + NAD+
-
-
-
?
2-oxobutanoate + NH3 + NADH
15.8% of the activity with pyruvate
349556
Streptomyces phaeochromogenes
2-aminobutanoate + H2O + NAD+
-
-
-
?
3-hydroxypyruvate + NH3 + NADH
-
349556
Lysinibacillus sphaericus
L-Ser + H2O + NAD+
-
-
-
?
3-hydroxypyruvate + NH3 + NADH
-
349556
Streptomyces clavuligerus
L-Ser + H2O + NAD+
-
-
-
?
3-hydroxypyruvate + NH3 + NADH
32.3% of the activity with pyruvate
349556
Streptomyces phaeochromogenes
L-Ser + H2O + NAD+
-
-
-
?
glyoxylate + NH3 + NADH
-
349556
Lysinibacillus sphaericus
aminoacetate + NAD+ + H2O
-
-
-
?
glyoxylate + NH3 + NADH
-
349556
Streptomyces clavuligerus
aminoacetate + NAD+ + H2O
-
-
-
?
glyoxylate + NH3 + NADH
13.3% of the activity with pyruvate
349556
Streptomyces phaeochromogenes
aminoacetate + NAD+ + H2O
-
-
-
?
L-2-aminobutanoate + H2O + NAD+
-
349556
Bacillus subtilis
2-oxobutanoate + NH3 + NADH
-
-
-
?
L-2-aminobutanoate + H2O + NAD+
-
349556
Lysinibacillus sphaericus
2-oxobutanoate + NH3 + NADH
-
-
-
?
L-2-aminobutanoate + H2O + NAD+
1.6% of the activity with L-Ala
349556
Streptomyces phaeochromogenes
2-oxobutanoate + NH3 + NADH
-
-
-
-
L-Ala + H2O + NAD+
-
349556
Bacillus subtilis
pyruvate + NH3 + NADH
-
349556
Bacillus subtilis
r
L-Ala + H2O + NAD+
-
349556
Lysinibacillus sphaericus
pyruvate + NH3 + NADH
-
349556
Lysinibacillus sphaericus
r
L-Ala + H2O + NAD+
-
349556
Streptomyces coelicolor
pyruvate + NH3 + NADH
-
349556
Streptomyces coelicolor
r
L-Ala + H2O + NAD+
-
349556
Streptomyces griseus
pyruvate + NH3 + NADH
-
349556
Streptomyces griseus
r
L-Ala + H2O + NAD+
-
349556
Streptomyces albus
pyruvate + NH3 + NADH
-
349556
Streptomyces albus
r
L-Ala + H2O + NAD+
-
349556
Streptomyces olivochromogenes
pyruvate + NH3 + NADH
-
349556
Streptomyces olivochromogenes
r
L-Ala + H2O + NAD+
-
349556
Streptomyces phaeochromogenes
pyruvate + NH3 + NADH
-
349556
Streptomyces phaeochromogenes
r
L-Ala + H2O + NAD+
-
349556
Streptomyces flaveus
pyruvate + NH3 + NADH
-
349556
Streptomyces flaveus
r
L-Ala + H2O + NAD+
-
349556
Streptomyces bobili
pyruvate + NH3 + NADH
-
349556
Streptomyces bobili
r
L-Ala + H2O + NAD+
-
349556
Streptomyces roseochromogenes
pyruvate + NH3 + NADH
-
349556
Streptomyces roseochromogenes
r
L-Ala + H2O + NAD+
-
349556
Streptomyces ruber
pyruvate + NH3 + NADH
-
349556
Streptomyces ruber
r
L-Ala + H2O + NAD+
-
349556
Streptomyces aureus
pyruvate + NH3 + NADH
-
349556
Streptomyces aureus
r
L-Ala + H2O + NAD+
-
349556
Streptomyces lydicus
pyruvate + NH3 + NADH
-
349556
Streptomyces lydicus
r
L-Ala + H2O + NAD+
-
349556
Streptomyces hygroscopicus
pyruvate + NH3 + NADH
-
349556
Streptomyces hygroscopicus
r
L-Ala + H2O + NAD+
-
349556
Streptomyces caespitosus
pyruvate + NH3 + NADH
-
349556
Streptomyces caespitosus
r
L-Ala + H2O + NAD+
-
349556
Streptomyces clavuligerus
pyruvate + NH3 + NADH
-
349556
Streptomyces clavuligerus
r
L-Ala + H2O + NAD+
-
349556
Streptomyces griseoluteus
pyruvate + NH3 + NADH
-
349556
Streptomyces griseoluteus
r
L-Ala + H2O + NAD+
-
349556
Kitasatospora albolonga
pyruvate + NH3 + NADH
-
349556
Kitasatospora albolonga
r
L-Ala + H2O + NAD+
-
349556
Micromonospora melanosporea
pyruvate + NH3 + NADH
-
349556
Micromonospora melanosporea
r
L-Ala + H2O + NAD+
-
349556
Streptomyces roseus
pyruvate + NH3 + NADH
-
349556
Streptomyces roseus
r
L-Ser + H2O + NAD+
-
349556
Bacillus subtilis
3-hydroxypyruvate + NH3 + NADH
-
-
-
?
L-Ser + H2O + NAD+
-
349556
Lysinibacillus sphaericus
3-hydroxypyruvate + NH3 + NADH
-
-
-
-
L-Ser + H2O + NAD+
2.4% of the activity with L-Ala
349556
Streptomyces phaeochromogenes
3-hydroxypyruvate + NH3 + NADH
-
-
-
-
oxaloacetate + NH3 + NADH
-
349556
Lysinibacillus sphaericus
L-Asp + H2O + NAD+
-
-
-
?
oxaloacetate + NH3 + NADH
43.1% of the activity with pyruvate
349556
Streptomyces phaeochromogenes
L-Asp + H2O + NAD+
-
-
-
?
Subunits
Subunits
Commentary
Organism
hexamer
-
Lysinibacillus sphaericus
hexamer
6 * 39000, SDS-PAGE
Streptomyces phaeochromogenes
hexamer
-
Bacillus subtilis
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
60
-
-
Streptomyces phaeochromogenes
Temperature Stability [°C]
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
45
-
20 min, pH 7.0, stable
Streptomyces phaeochromogenes
50
-
-
Lysinibacillus sphaericus
50
-
-
Streptomyces coelicolor
50
-
20 min, pH 7.0, 29% loss of activity
Streptomyces phaeochromogenes
55
-
20 min, pH 7.0, 50% loss of activity
Streptomyces phaeochromogenes
60
-
-
Lysinibacillus sphaericus
60
-
20 min, pH 7.0, 70% loss of activity
Streptomyces phaeochromogenes
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8
-
reductive amination
Streptomyces phaeochromogenes
10
-
oxidative deamination
Streptomyces phaeochromogenes
pH Stability
pH Stability
pH Stability Maximum
Commentary
Organism
7
10
20°C, 3 h, stable
Streptomyces phaeochromogenes
Cofactor
Cofactor
Commentary
Organism
Structure
NAD+
-
Kitasatospora albolonga
NAD+
-
Micromonospora melanosporea
NAD+
-
Streptomyces albus
NAD+
-
Streptomyces aureus
NAD+
-
Streptomyces bobili
NAD+
-
Streptomyces caespitosus
NAD+
-
Streptomyces coelicolor
NAD+
-
Streptomyces flaveus
NAD+
-
Streptomyces griseoluteus
NAD+
-
Streptomyces griseus
NAD+
-
Streptomyces lydicus
NAD+
-
Streptomyces olivochromogenes
NAD+
-
Streptomyces phaeochromogenes
NAD+
-
Streptomyces roseochromogenes
NAD+
-
Streptomyces roseus
NAD+
-
Streptomyces ruber
NAD+
-
Streptomyces clavuligerus
NAD+
-
Streptomyces hygroscopicus
NAD+
-
Lysinibacillus sphaericus
NAD+
-
Bacillus subtilis
NADH
-
Kitasatospora albolonga
NADH
-
Micromonospora melanosporea
NADH
-
Streptomyces albus
NADH
-
Streptomyces aureus
NADH
-
Streptomyces bobili
NADH
-
Streptomyces caespitosus
NADH
-
Streptomyces coelicolor
NADH
-
Streptomyces flaveus
NADH
-
Streptomyces griseoluteus
NADH
-
Streptomyces griseus
NADH
-
Streptomyces lydicus
NADH
-
Streptomyces olivochromogenes
NADH
-
Streptomyces phaeochromogenes
NADH
-
Streptomyces roseochromogenes
NADH
-
Streptomyces roseus
NADH
-
Streptomyces ruber
NADH
-
Streptomyces clavuligerus
NADH
-
Streptomyces hygroscopicus
NADH
-
Lysinibacillus sphaericus
NADH
-
Bacillus subtilis
NADP+
0.6% of the activity with NAD+
Streptomyces phaeochromogenes
NADPH
3.5% of the activity with NADH
Streptomyces phaeochromogenes
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
1,10-phenanthroline
activation
Streptomyces phaeochromogenes
2,2'-dipyridyl
activation
Streptomyces phaeochromogenes
2-mercaptoethanol
activation
Streptomyces phaeochromogenes
diethyldithiocarbamate
activation
Streptomyces phaeochromogenes
dithiothreitol
activation
Streptomyces phaeochromogenes
EDTA
activation
Streptomyces phaeochromogenes
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NAD+
-
Kitasatospora albolonga
NAD+
-
Micromonospora melanosporea
NAD+
-
Streptomyces albus
NAD+
-
Streptomyces aureus
NAD+
-
Streptomyces bobili
NAD+
-
Streptomyces caespitosus
NAD+
-
Streptomyces coelicolor
NAD+
-
Streptomyces flaveus
NAD+
-
Streptomyces griseoluteus
NAD+
-
Streptomyces griseus
NAD+
-
Streptomyces lydicus
NAD+
-
Streptomyces olivochromogenes
NAD+
-
Streptomyces phaeochromogenes
NAD+
-
Streptomyces roseochromogenes
NAD+
-
Streptomyces roseus
NAD+
-
Streptomyces ruber
NAD+
-
Streptomyces clavuligerus
NAD+
-
Streptomyces hygroscopicus
NAD+
-
Lysinibacillus sphaericus
NAD+
-
Bacillus subtilis
NADH
-
Kitasatospora albolonga
NADH
-
Micromonospora melanosporea
NADH
-
Streptomyces albus
NADH
-
Streptomyces aureus
NADH
-
Streptomyces bobili
NADH
-
Streptomyces caespitosus
NADH
-
Streptomyces coelicolor
NADH
-
Streptomyces flaveus
NADH
-
Streptomyces griseoluteus
NADH
-
Streptomyces griseus
NADH
-
Streptomyces lydicus
NADH
-
Streptomyces olivochromogenes
NADH
-
Streptomyces phaeochromogenes
NADH
-
Streptomyces roseochromogenes
NADH
-
Streptomyces roseus
NADH
-
Streptomyces ruber
NADH
-
Streptomyces clavuligerus
NADH
-
Streptomyces hygroscopicus
NADH
-
Lysinibacillus sphaericus
NADH
-
Bacillus subtilis
NADP+
0.6% of the activity with NAD+
Streptomyces phaeochromogenes
NADPH
3.5% of the activity with NADH
Streptomyces phaeochromogenes
Crystallization (Commentary) (protein specific)
Crystallization
Organism
-
Streptomyces phaeochromogenes
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
Cu2+
-
Streptomyces phaeochromogenes
Cu2+
-
Streptomyces clavuligerus
Cu2+
-
Lysinibacillus sphaericus
monoiodoacetate
-
Streptomyces phaeochromogenes
Pb2+
-
Streptomyces phaeochromogenes
Pb2+
-
Lysinibacillus sphaericus
PCMB
-
Streptomyces phaeochromogenes
PCMB
-
Lysinibacillus sphaericus
PCMB
-
Bacillus subtilis
Zn2+
-
Streptomyces phaeochromogenes
Zn2+
-
Bacillus subtilis
Zn2+
-
Streptomyces clavuligerus
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.036
-
NAD+
pH 10.0
Streptomyces phaeochromogenes
0.047
-
NADH
-
Streptomyces phaeochromogenes
0.29
-
pyruvate
-
Streptomyces phaeochromogenes
1.9
-
L-Ala
pH 8.0
Streptomyces phaeochromogenes
3.6
-
L-Ala
pH 9.0
Streptomyces phaeochromogenes
7.1
-
L-Ala
pH 10.0
Streptomyces phaeochromogenes
61
-
NH4+
-
Streptomyces phaeochromogenes
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
39000
-
6 * 39000, SDS-PAGE
Streptomyces phaeochromogenes
240000
-
gel filtration
Streptomyces phaeochromogenes
Purification (Commentary) (protein specific)
Commentary
Organism
-
Streptomyces phaeochromogenes
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
22.8
-
-
Streptomyces phaeochromogenes
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2-oxobutanoate + NH3 + NADH
-
349556
Lysinibacillus sphaericus
2-aminobutanoate + H2O + NAD+
-
-
-
?
2-oxobutanoate + NH3 + NADH
15.8% of the activity with pyruvate
349556
Streptomyces phaeochromogenes
2-aminobutanoate + H2O + NAD+
-
-
-
?
3-hydroxypyruvate + NH3 + NADH
-
349556
Lysinibacillus sphaericus
L-Ser + H2O + NAD+
-
-
-
?
3-hydroxypyruvate + NH3 + NADH
-
349556
Streptomyces clavuligerus
L-Ser + H2O + NAD+
-
-
-
?
3-hydroxypyruvate + NH3 + NADH
32.3% of the activity with pyruvate
349556
Streptomyces phaeochromogenes
L-Ser + H2O + NAD+
-
-
-
?
glyoxylate + NH3 + NADH
-
349556
Lysinibacillus sphaericus
aminoacetate + NAD+ + H2O
-
-
-
?
glyoxylate + NH3 + NADH
-
349556
Streptomyces clavuligerus
aminoacetate + NAD+ + H2O
-
-
-
?
glyoxylate + NH3 + NADH
13.3% of the activity with pyruvate
349556
Streptomyces phaeochromogenes
aminoacetate + NAD+ + H2O
-
-
-
?
L-2-aminobutanoate + H2O + NAD+
-
349556
Bacillus subtilis
2-oxobutanoate + NH3 + NADH
-
-
-
?
L-2-aminobutanoate + H2O + NAD+
-
349556
Lysinibacillus sphaericus
2-oxobutanoate + NH3 + NADH
-
-
-
?
L-2-aminobutanoate + H2O + NAD+
1.6% of the activity with L-Ala
349556
Streptomyces phaeochromogenes
2-oxobutanoate + NH3 + NADH
-
-
-
-
L-Ala + H2O + NAD+
-
349556
Bacillus subtilis
pyruvate + NH3 + NADH
-
349556
Bacillus subtilis
r
L-Ala + H2O + NAD+
-
349556
Lysinibacillus sphaericus
pyruvate + NH3 + NADH
-
349556
Lysinibacillus sphaericus
r
L-Ala + H2O + NAD+
-
349556
Streptomyces coelicolor
pyruvate + NH3 + NADH
-
349556
Streptomyces coelicolor
r
L-Ala + H2O + NAD+
-
349556
Streptomyces griseus
pyruvate + NH3 + NADH
-
349556
Streptomyces griseus
r
L-Ala + H2O + NAD+
-
349556
Streptomyces albus
pyruvate + NH3 + NADH
-
349556
Streptomyces albus
r
L-Ala + H2O + NAD+
-
349556
Streptomyces olivochromogenes
pyruvate + NH3 + NADH
-
349556
Streptomyces olivochromogenes
r
L-Ala + H2O + NAD+
-
349556
Streptomyces phaeochromogenes
pyruvate + NH3 + NADH
-
349556
Streptomyces phaeochromogenes
r
L-Ala + H2O + NAD+
-
349556
Streptomyces flaveus
pyruvate + NH3 + NADH
-
349556
Streptomyces flaveus
r
L-Ala + H2O + NAD+
-
349556
Streptomyces bobili
pyruvate + NH3 + NADH
-
349556
Streptomyces bobili
r
L-Ala + H2O + NAD+
-
349556
Streptomyces roseochromogenes
pyruvate + NH3 + NADH
-
349556
Streptomyces roseochromogenes
r
L-Ala + H2O + NAD+
-
349556
Streptomyces ruber
pyruvate + NH3 + NADH
-
349556
Streptomyces ruber
r
L-Ala + H2O + NAD+
-
349556
Streptomyces aureus
pyruvate + NH3 + NADH
-
349556
Streptomyces aureus
r
L-Ala + H2O + NAD+
-
349556
Streptomyces lydicus
pyruvate + NH3 + NADH
-
349556
Streptomyces lydicus
r
L-Ala + H2O + NAD+
-
349556
Streptomyces hygroscopicus
pyruvate + NH3 + NADH
-
349556
Streptomyces hygroscopicus
r
L-Ala + H2O + NAD+
-
349556
Streptomyces caespitosus
pyruvate + NH3 + NADH
-
349556
Streptomyces caespitosus
r
L-Ala + H2O + NAD+
-
349556
Streptomyces clavuligerus
pyruvate + NH3 + NADH
-
349556
Streptomyces clavuligerus
r
L-Ala + H2O + NAD+
-
349556
Streptomyces griseoluteus
pyruvate + NH3 + NADH
-
349556
Streptomyces griseoluteus
r
L-Ala + H2O + NAD+
-
349556
Kitasatospora albolonga
pyruvate + NH3 + NADH
-
349556
Kitasatospora albolonga
r
L-Ala + H2O + NAD+
-
349556
Micromonospora melanosporea
pyruvate + NH3 + NADH
-
349556
Micromonospora melanosporea
r
L-Ala + H2O + NAD+
-
349556
Streptomyces roseus
pyruvate + NH3 + NADH
-
349556
Streptomyces roseus
r
L-Ser + H2O + NAD+
-
349556
Bacillus subtilis
3-hydroxypyruvate + NH3 + NADH
-
-
-
?
L-Ser + H2O + NAD+
-
349556
Lysinibacillus sphaericus
3-hydroxypyruvate + NH3 + NADH
-
-
-
-
L-Ser + H2O + NAD+
2.4% of the activity with L-Ala
349556
Streptomyces phaeochromogenes
3-hydroxypyruvate + NH3 + NADH
-
-
-
-
oxaloacetate + NH3 + NADH
-
349556
Lysinibacillus sphaericus
L-Asp + H2O + NAD+
-
-
-
?
oxaloacetate + NH3 + NADH
43.1% of the activity with pyruvate
349556
Streptomyces phaeochromogenes
L-Asp + H2O + NAD+
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
hexamer
-
Lysinibacillus sphaericus
hexamer
6 * 39000, SDS-PAGE
Streptomyces phaeochromogenes
hexamer
-
Bacillus subtilis
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
60
-
-
Streptomyces phaeochromogenes
Temperature Stability [°C] (protein specific)
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
45
-
20 min, pH 7.0, stable
Streptomyces phaeochromogenes
50
-
-
Lysinibacillus sphaericus
50
-
-
Streptomyces coelicolor
50
-
20 min, pH 7.0, 29% loss of activity
Streptomyces phaeochromogenes
55
-
20 min, pH 7.0, 50% loss of activity
Streptomyces phaeochromogenes
60
-
-
Lysinibacillus sphaericus
60
-
20 min, pH 7.0, 70% loss of activity
Streptomyces phaeochromogenes
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8
-
reductive amination
Streptomyces phaeochromogenes
10
-
oxidative deamination
Streptomyces phaeochromogenes
pH Stability (protein specific)
pH Stability
pH Stability Maximum
Commentary
Organism
7
10
20°C, 3 h, stable
Streptomyces phaeochromogenes
Other publictions for EC 1.4.1.1
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
741751
Szymanska-Majchrzak
Isotopic effects in mechanist ...
Bacillus subtilis
Appl. Radiat. Isot.
123
21-25
2017
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
742071
Reshma
Design and development of new ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Bioorg. Med. Chem.
24
4499-4508
2016
-
-
1
1
-
-
2
-
-
-
-
-
-
9
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
1
-
-
2
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
742134
Lerchner
Engineering of alanine dehydr ...
Bacillus subtilis
Biotechnol. Appl. Biochem.
63
616-624
2016
-
1
1
-
4
-
-
8
-
-
-
-
-
4
-
-
-
-
-
-
-
-
2
-
-
-
-
8
-
-
-
2
-
-
-
-
1
1
2
-
4
-
-
-
-
8
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
8
-
-
-
-
-
-
-
-
8
8
743605
Giffin
Role of alanine dehydrogenase ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
PLoS ONE
11
e0155522
2016
-
-
-
-
-
-
-
-
-
-
-
-
-
10
-
-
-
-
-
-
-
-
-
-
-
-
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-
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-
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
1
1
-
-
742450
Saxena
Design and development of nov ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Eur. J. Med. Chem.
92
401-414
2015
-
-
-
-
-
-
4
2
-
-
-
-
-
9
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
4
4
-
2
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
742705
Li
Domain motions and functional ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Int. J. Mol. Sci.
16
29383-29397
2015
-
-
-
1
-
-
-
-
-
-
-
-
-
9
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
1
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-
-
-
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-
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-
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-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
743722
Fernandes
Alteration of substrate speci ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Protein Eng. Des. Sel.
28
29-35
2015
-
-
1
-
2
-
-
2
-
-
-
-
-
9
-
-
-
-
-
-
-
-
15
-
-
-
-
2
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
15
-
-
-
-
2
-
-
-
-
-
-
-
-
20
20
743120
Ling
Molecular dynamics simulation ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
J. Mol. Graph. Model.
50
61-70
2014
-
-
-
-
3
-
-
-
-
-
-
-
-
9
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
723883
Lu
Crystallization and preliminar ...
Bacillus megaterium, Bacillus megaterium WSH-002
Acta Crystallogr. Sect. F
69
934-936
2013
-
-
1
1
-
-
-
-
-
-
1
2
-
4
-
-
1
-
-
-
-
-
2
1
-
-
-
-
-
-
-
2
-
-
-
-
-
1
2
1
-
-
-
-
-
-
-
-
1
2
-
-
-
1
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
741520
Wen
Crystallization and prelimina ...
Bacillus pseudofirmus, Bacillus pseudofirmus OF4
Acta Crystallogr. Sect. F
69
1227-1230
2013
-
-
1
1
-
-
-
-
-
-
1
-
-
3
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
742778
Jeong
Regulation of the ald gene en ...
Mycolicibacterium smegmatis
J. Bacteriol.
195
3610-3620
2013
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
743765
Zech
Dynamics of amino acid utiliz ...
Phaeobacter inhibens, Phaeobacter inhibens DSM 17395
Proteomics
13
2869-2885
2013
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
725267
Giffin
ald of Mycobacterium tuberculo ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
J. Bacteriol.
194
1045-1054
2012
-
-
1
-
1
-
-
6
3
-
-
6
-
162
-
-
1
-
-
-
1
-
6
-
1
-
-
-
1
-
-
2
-
-
-
-
-
1
2
-
1
-
-
-
-
6
3
-
-
6
-
-
-
1
-
-
1
-
6
-
1
-
-
-
1
-
-
-
1
2
2
1
-
-
724147
Al-Onazi
-
Isolation and characterization ...
Thielaviopsis paradoxa
Asian J. Appl. Sci.
4
702-711
2011
2
-
-
-
-
-
3
5
-
-
-
7
-
1
-
-
1
-
-
-
-
-
7
-
1
-
-
-
2
-
-
2
-
-
-
2
-
-
2
-
-
-
-
3
-
5
-
-
-
7
-
-
-
1
-
-
-
-
7
-
1
-
-
-
2
-
-
-
-
1
1
-
-
-
712264
Nakane
-
Coimmobilization of malic enzy ...
Geobacillus stearothermophilus
J. Appl. Polym. Sci.
116
2901-2905
2010
-
-
-
-
1
-
1
-
-
-
-
1
-
1
-
-
-
-
-
1
-
-
1
-
1
-
-
-
1
-
-
2
-
-
-
-
-
-
2
-
1
-
-
1
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
712305
Pernil
Catabolic function of compartm ...
Anabaena sp., Anabaena sp. PCC 7120
J. Bacteriol.
192
5165-5172
2010
-
-
1
-
1
-
-
-
-
-
-
2
-
22
-
-
-
-
-
2
1
-
2
-
1
-
-
-
1
-
-
2
-
-
-
-
-
1
2
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
1
-
2
-
1
-
-
-
1
-
-
-
-
2
2
-
-
-
705545
Ye
Heterologous expression of the ...
Bacillus subtilis, Bacillus subtilis natto, no activity in Lactococcus lactis
Microbiol. Res.
165
268-275
2009
-
1
1
-
-
-
-
-
-
-
1
2
-
9
-
-
1
-
-
-
-
-
2
1
1
1
-
-
-
-
-
1
-
-
-
-
1
1
1
-
-
-
-
-
-
-
-
-
1
2
-
-
-
1
-
-
-
-
2
1
1
1
-
-
-
-
-
-
-
-
-
-
-
-
705546
Ye
Heterologous expression of the ...
Bacillus subtilis
Microbiol. Res.
165
268-775
2009
-
1
1
-
-
-
-
-
-
-
2
-
-
7
-
-
1
-
-
-
2
-
1
-
2
-
-
-
-
-
-
1
-
-
-
-
1
1
1
-
-
-
-
-
-
-
-
-
2
-
-
-
-
1
-
-
2
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
688401
Agren
Three-dimensional structures o ...
Mycobacterium tuberculosis
J. Mol. Biol.
377
1161-1173
2008
-
-
1
1
3
-
-
2
-
-
1
-
-
2
-
-
1
-
-
-
-
-
1
1
-
-
-
2
-
-
-
1
-
-
-
-
-
1
1
1
3
-
-
-
-
2
-
-
1
-
-
-
-
1
-
-
-
-
1
1
-
-
-
2
-
-
-
-
-
-
-
-
-
-
706642
Tripathi
Crystal structures of the Myco ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Proteins Struct. Funct. Genet.
72
1089-1095
2008
-
-
1
1
-
-
-
-
-
-
1
-
-
9
-
-
1
-
-
-
-
1
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
1
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
1
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
684618
Wada
Alanine production in an H+-AT ...
Geobacillus stearothermophilus
Appl. Microbiol. Biotechnol.
76
819-825
2007
-
-
1
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
684625
Zhang
Production of L-alanine by met ...
Geobacillus stearothermophilus, Geobacillus stearothermophilus XL-65-6
Appl. Microbiol. Biotechnol.
77
355-366
2007
-
-
1
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
684793
Baysal
Encapsulation of PEG-urease/PE ...
Bacillus subtilis
Artif. Cells Blood Substit. Immobil. Biotechnol.
35
391-403
2007
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
674289
Lahmi
Alanine dehydrogenase activity ...
Synechococcus elongatus
J. Bacteriol.
188
5258-5265
2006
-
1
-
-
1
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
675815
Scandurra
Contribution of L-alanine dehy ...
Mycobacterium tuberculosis, no activity in Mycobacterium bovis BCG
Microbiol. Immunol.
50
805-810
2006
-
1
1
-
-
-
-
-
-
-
1
-
-
5
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
1
1
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
695918
Gorzynska
Inducible transcription of gen ...
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Markerless mutagenesis in Meth ...
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Fundamental differences in bio ...
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A novel archaeal alanine dehyd ...
Archaeoglobus fulgidus
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5
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1
1
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3
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2
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Lodwig
Regulation of L-alanine dehydr ...
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2004
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656546
Gallagher
Structure of alanine dehydroge ...
Archaeoglobus fulgidus
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2004
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656576
Ashida
-
Conversion of cofactor specifi ...
Phormidium lapideum, Phormidium lapideum Ac10, Shewanella sp., Shewanella sp. Ac10
J. Mol. Catal. B
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2004
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6
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13
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654082
Smith
Crystallization and phasing of ...
Archaeoglobus fulgidus
Acta Crystallogr. Sect. D
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2003
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1
1
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655519
Irwin
Alanine dehydrogenase from the ...
Shewanella sp., Shewanella sp. PA-43
Extremophiles
7
135-143
2003
1
-
1
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5
18
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2
2
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7
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1
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1
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1
21
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2
1
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1
21
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1
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656474
Bae
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Purification and biochemical c ...
Thermus caldophilus, Thermus caldophilus GK24
J. Microbiol. Biotechnol.
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2003
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2
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656570
Kato
-
Purification and characterizat ...
Vibrio proteolyticus
J. Mol. Catal. B
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373-378
2003
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1
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8
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1
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3
1
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3
-
2
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1
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349591
Feng
Mycobacterium smegmatis L-Alan ...
Mycolicibacterium smegmatis
J. Bacteriol.
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2002
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349592
Vadas
Room-temperature synthesis of ...
Archaeoglobus fulgidus
Biotechnol. Prog.
18
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2002
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1
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2
-
1
-
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1
1
-
-
-
-
-
-
-
-
-
-
349594
Usha
Glycine and alanine dehydrogen ...
Mycolicibacterium smegmatis
Can. J. Microbiol.
48
7-13
2002
-
-
-
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1
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4
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2
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-
657148
Baysal
Screening and simple purificat ...
Bacillus megaterium, Bacillus megaterium LA 199
Prep. Biochem. Biotechnol.
32
277-285
2002
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1
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4
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1
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1
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2
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1
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2
1
-
-
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-
-
-
-
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-
349584
Irwin
Characterization of alanine an ...
Bacteria, Phormidium lapideum, Shewanella sp., Vibrio proteolyticus
Extremophiles
5
199-211
2001
-
-
-
-
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1
-
-
-
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2
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12
-
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1
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3
4
3
1
1
7
-
4
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8
-
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8
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1
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2
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1
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3
4
3
1
1
7
-
4
-
-
-
-
-
-
-
-
-
349581
Laue
Purification, properties and p ...
Bilophila wadsworthia
Arch. Microbiol.
174
162-167
2000
-
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1
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5
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1
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1
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1
1
13
1
2
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2
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2
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2
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2
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1
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5
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3
1
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1
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-
1
1
13
1
2
-
2
-
2
-
-
-
-
-
-
-
-
-
349583
Allaway
Identification of alanine dehy ...
Rhizobium leguminosarum
Mol. Microbiol.
36
508-515
2000
-
-
-
-
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-
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2
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2
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2
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1
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1
-
-
2
-
-
-
-
-
-
-
-
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-
-
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-
349588
Hutter
Properties of the 40 kDa antig ...
Mycobacterium tuberculosis
Biochem. J.
343
669-672
1999
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2
5
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1
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7
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2
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2
2
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4
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4
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2
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5
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1
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-
-
-
-
-
7
-
-
-
2
-
2
2
-
-
-
-
-
-
-
-
349593
Galkin
Cold-adapted alanine dehydroge ...
Bacillus subtilis, Carnobacterium sp., Carnobacterium sp. St2, Geobacillus stearothermophilus, Shewanella sp., Shewanella sp. Ac10, Vibrio proteolyticus
Appl. Environ. Microbiol.
65
4014-4020
1999
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2
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1
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8
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1
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-
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1
-
7
3
-
-
8
3
-
-
-
10
-
-
-
-
-
2
10
-
-
1
-
-
-
8
-
-
1
-
-
-
-
-
-
-
1
-
7
3
-
-
8
3
-
-
-
-
-
-
-
-
-
-
349582
Hutter
Host vector system for high-le ...
Mycobacterium tuberculosis
Gene
212
21-29
1998
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1
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1
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1
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2
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1
2
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-
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-
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-
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1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
349589
Sedelnikova
Crystallization of the alanine ...
Phormidium lapideum
Acta Crystallogr. Sect. D
54
407-408
1998
-
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-
1
-
-
-
-
-
-
-
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2
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1
-
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-
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1
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2
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2
1
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1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
349590
Kim
-
Unusual allosteric property of ...
Bacillus subtilis
J. Biochem. Mol. Biol.
31
25-30
1998
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1
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2
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2
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1
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-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
349595
Chowdhury
Alanine dehydrogenase from Ent ...
Klebsiella aerogenes
Biosci. Biotechnol. Biochem.
62
2357-2363
1998
-
-
1
-
-
-
4
4
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3
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5
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1
1
-
-
1
1
11
1
-
-
2
-
2
-
1
6
-
-
-
-
-
1
6
-
-
-
-
4
-
4
-
-
3
-
-
-
-
1
-
-
1
1
11
1
-
-
2
-
2
-
1
-
-
-
-
-
-
-
349587
Delforge
Identification of lysine 74 in ...
Bacillus subtilis
J. Biol. Chem.
272
2276-2284
1997
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3
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2
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-
-
-
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1
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2
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-
-
-
-
2
-
-
-
-
3
-
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-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
349563
Sawa
Purification and characterizat ...
Bacillus subtilis, Phormidium lapideum
J. Biochem.
116
995-1000
1994
1
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-
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-
1
14
5
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2
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4
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1
-
-
-
1
-
5
2
1
-
2
-
2
2
1
4
-
-
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1
-
-
4
-
-
1
-
14
-
5
-
-
2
-
-
-
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1
-
-
1
-
5
2
1
-
2
-
2
2
1
-
-
-
-
-
-
-
349599
Brunhuber
The biochemistry and enzymolog ...
Anabaena cylindrica, Bacillus cereus, Bacillus japonicum, Bacillus licheniformis, Bacillus subtilis, Geobacillus stearothermophilus, Halobacterium salinarum, Kitasatospora aureofaciens, Lysinibacillus sphaericus, Mycobacterium tuberculosis, Pseudomonas sp., Thermus thermophilus
Crit. Rev. Biochem. Mol. Biol.
29
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1994
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8
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1
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-
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-
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-
-
12
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-
-
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-
19
-
-
24
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-
-
-
-
-
24
-
-
-
-
8
-
42
-
-
1
-
-
-
-
-
-
-
-
-
12
-
-
-
-
-
19
-
-
-
-
-
-
-
-
-
349586
Smith
Alanine dehydrogenase from soy ...
Rhizobium sp.
Arch. Biochem. Biophys.
304
379-385
1993
-
-
-
-
-
-
7
5
-
-
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-
-
2
-
-
-
1
-
1
-
-
1
-
-
-
-
-
-
-
-
2
3
-
-
-
-
-
2
-
-
-
-
7
3
5
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
349597
Siranosian
Alanine dehydrogenase (ald) is ...
Bacillus subtilis
J. Bacteriol.
175
6789-6796
1993
-
-
-
-
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1
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4
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2
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2
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-
2
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-
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-
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-
1
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-
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-
-
-
2
-
-
-
-
-
-
-
-
-
-
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-
-
-
349536
Sakamoto
-
Gene cloning, purification and ...
Geobacillus stearothermophilus
J. Ferment. Bioeng.
69
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1990
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1
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1
1
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1
1
10
1
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-
3
-
2
2
1
2
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-
-
-
-
1
2
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-
-
-
-
-
4
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-
2
1
-
-
-
1
-
-
1
1
10
1
-
-
3
-
2
2
1
-
-
-
-
-
-
-
349537
Ohshima
Thermostable alanine dehydroge ...
Lysinibacillus sphaericus
Eur. J. Biochem.
191
715-720
1990
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3
6
5
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2
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1
2
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1
1
-
-
1
1
6
1
-
-
3
-
1
2
1
2
-
-
-
-
-
-
2
-
-
3
-
6
-
5
-
-
2
-
1
-
-
1
-
-
1
1
6
1
-
-
3
-
1
2
1
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-
-
-
-
-
-
349538
Glasfeld
The stereospecificities of sev ...
Acholeplasma laidlawii
J. Biol. Chem.
265
11692-11699
1990
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2
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2
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
349539
Honorat
-
Synthesis of L-alanine and L-v ...
Bacillus megaterium
Enzyme Microb. Technol.
12
515-520
1990
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-
-
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4
3
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1
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2
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8
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1
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1
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2
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2
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2
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4
-
3
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1
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-
2
-
8
-
1
-
1
-
2
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-
-
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-
-
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349540
Schultz
Enzymes of ammonia assimilatio ...
Frankia sp.
J. Bacteriol.
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1380-1384
1990
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1
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2
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2
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2
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1
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1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
349543
Kuroda
Alanine dehydrogenases from tw ...
Geobacillus stearothermophilus, Lysinibacillus sphaericus
Biochemistry
29
1009-1015
1990
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1
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-
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3
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4
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2
2
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2
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4
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1
4
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-
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3
-
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-
1
-
-
-
-
2
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
349541
El-Awamry
Partial purification and prope ...
Cunninghamella elegans
Zentralbl. Mikrobiol.
144
231-240
1989
-
-
-
-
-
2
3
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5
-
-
-
2
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1
-
-
2
1
1
1
-
1
-
1
-
2
2
-
2
-
-
-
-
-
-
2
-
-
2
-
3
-
-
-
5
-
-
-
-
-
1
-
2
1
1
1
-
1
-
1
-
2
2
-
-
-
-
-
-
-
-
349542
Flores
-
Ammonium-assimilating enzymes ...
Saccharopolyspora erythraea
J. Gen. Appl. Microbiol.
35
203-211
1989
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-
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1
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4
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2
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2
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3
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4
-
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-
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-
-
-
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349544
Ohshima
Continous production of 3-fluo ...
Lysinibacillus sphaericus
Biotechnol. Bioeng.
34
394-397
1989
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1
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5
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2
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1
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2
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1
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2
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5
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-
-
2
-
-
-
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1
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349545
Caballero
Purification and properties of ...
Rhodobacter capsulatus
J. Bacteriol.
171
3205-3210
1989
4
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1
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1
2
1
2
-
1
-
2
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-
3
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-
4
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3
-
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4
-
5
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-
3
1
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1
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-
1
2
1
2
-
1
-
2
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349546
Vancurova
A further characterization of ...
Kitasatospora aureofaciens
J. Basic Microbiol.
29
185-189
1989
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4
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-
7
-
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7
-
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7
-
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-
4
-
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1
1
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-
-
7
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
349547
Vancura
Alanine dehydrogenase from Str ...
Streptomyces fradiae
Eur. J. Biochem.
179
221-227
1989
-
-
-
-
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7
7
-
-
2
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-
2
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1
-
-
-
1
2
7
1
1
-
-
-
2
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-
6
-
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-
-
-
6
-
-
-
-
7
-
7
-
-
2
-
-
-
-
1
-
-
1
2
7
1
1
-
-
-
2
-
-
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-
-
-
-
-
349596
Hutter B; Dick T
Increased alanine dehydrogenas ...
Mycolicibacterium smegmatis
FEMS Microbiol. Lett.
167
7-11
1989
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2
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2
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2
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-
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349548
Vancurova
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Purification and partial chara ...
Kitasatospora aureofaciens
Arch. Microbiol.
150
438-440
1988
-
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-
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5
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1
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1
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1
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1
1
1
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2
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3
-
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3
-
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5
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2
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1
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1
-
1
1
1
-
-
-
2
-
-
-
-
-
-
-
-
-
349549
Weiss
Use of primary deuterium and 1 ...
Bacillus subtilis
Biochemistry
27
4814-4822
1988
-
-
-
-
-
-
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1
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2
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2
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-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
6015
Crow
Properties of alanine dehydrog ...
Propionibacterium freudenreichii
Appl. Environ. Microbiol.
53
1885-1892
1987
-
-
-
-
-
-
3
-
-
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1
-
3
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1
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1
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2
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1
1
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2
-
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2
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3
-
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1
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1
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1
-
2
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
349551
Bellion
An NAD+-dependent alanine dehy ...
Pseudomonas sp., Pseudomonas sp. MA
Biochem. J.
244
565-570
1987
-
-
-
-
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7
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2
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1
-
-
-
1
-
4
1
-
-
-
-
1
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-
2
-
-
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-
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-
2
-
-
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7
-
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2
2
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1
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-
1
-
4
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
349552
Porumb
Structural and catalytic prope ...
Bacillus cereus
J. Biol. Chem.
262
4610-4615
1987
-
-
-
-
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-
1
-
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2
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-
3
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1
-
1
-
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-
1
1
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-
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-
2
-
-
2
-
-
-
-
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-
2
-
-
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-
1
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2
-
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1
1
-
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-
1
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
349553
Stams
-
Metabolism of L-alanine in Des ...
Desulfotomaculum ruminis, Desulfovibrio sp.
Arch. Microbiol.
145
277-279
1986
-
-
-
-
-
-
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2
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2
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-
-
-
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2
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4
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4
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2
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2
-
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-
-
-
-
-
-
-
-
-
-
-
-
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349554
Ohshima
-
Screening of thermostable leuc ...
Bacillus coagulans, Bacillus sp. (in: Bacteria), Geobacillus stearothermophilus, Lysinibacillus sphaericus
Biotechnol. Lett.
7
871-876
1985
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4
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9
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8
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8
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-
4
-
-
-
9
-
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-
-
-
-
-
-
-
-
-
349556
Itoh
-
Crystallization and properties ...
Bacillus subtilis, Kitasatospora albolonga, Lysinibacillus sphaericus, Micromonospora melanosporea, Streptomyces albus, Streptomyces aureus, Streptomyces bobili, Streptomyces caespitosus, Streptomyces clavuligerus, Streptomyces coelicolor, Streptomyces flaveus, Streptomyces griseoluteus, Streptomyces griseus, Streptomyces hygroscopicus, Streptomyces lydicus, Streptomyces olivochromogenes, Streptomyces phaeochromogenes, Streptomyces roseochromogenes, Streptomyces roseus, Streptomyces ruber
Agric. Biol. Chem.
47
2511-2519
1983
6
-
-
1
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-
12
7
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2
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20
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1
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-
-
1
-
36
3
1
-
7
-
2
-
1
42
-
-
-
6
-
-
42
1
-
-
-
12
-
7
-
-
2
-
-
-
-
1
-
-
1
-
36
3
1
-
7
-
2
-
1
-
-
-
-
-
-
-
349557
Bellion
-
Nitrogen assimilation in facul ...
Pseudomonas sp., Pseudomonas sp. AM1, Pseudomonas sp. MA
Curr. Microbiol.
9
37-44
1983
-
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-
-
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3
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2
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-
2
-
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-
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-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
349558
Lauwers
Thermal properties of enzymes ...
Anoxybacillus flavithermus, Bacillus caldolyticus
Antonie van Leeuwenhoek
49
191-201
1983
-
-
-
-
-
-
-
-
-
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2
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-
-
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2
-
3
1
3
-
-
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-
4
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
3
1
3
-
-
-
-
-
-
-
-
-
-
-
349565
Muresan
Catalytic properties of Sephar ...
Bacillus cereus
Biochim. Biophys. Acta
742
617-622
1983
-
-
-
-
-
1
-
10
-
-
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2
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-
1
-
-
-
-
-
1
-
-
-
5
-
2
-
1
2
-
-
-
-
-
-
2
-
-
1
-
-
-
10
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
5
-
2
-
1
-
-
-
-
-
-
-
349566
Mueller
-
Alanine dehydrogenase from bac ...
Anabaena cylindrica, Bradyrhizobium japonicum
Z. Naturforsch. C
37
927-936
1982
-
-
-
-
-
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8
2
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2
1
-
2
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-
1
-
-
3
1
-
5
1
-
-
-
-
2
-
-
4
-
-
-
-
-
-
4
-
-
-
-
8
-
2
-
-
2
1
-
-
-
1
-
3
1
-
5
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
349567
Tolxdorff-Neutzling
-
Metabolic role and regulation ...
Rhodobacter capsulatus
FEMS Microbiol. Lett.
13
155-159
1982
1
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-
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9
5
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1
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1
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1
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-
-
-
-
2
-
-
-
-
-
2
-
-
2
-
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-
1
-
-
2
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-
-
-
9
-
5
-
-
-
1
-
-
-
1
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
349559
Grimshaw
Kinetic mechanism of Bacillus ...
Bacillus subtilis
Biochemistry
20
5650-5655
1981
-
-
-
-
-
-
-
-
-
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-
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2
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1
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-
-
-
1
-
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-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
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-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
349560
Grimshaw
Use of isotope effects and pH ...
Bacillus subtilis
Biochemistry
20
5655-5661
1981
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
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-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
349568
Vali
L-Alanine dehydrogenase from T ...
Bacillus subtilis, Thermus thermophilus
Biochim. Biophys. Acta
615
34-47
1980
-
-
-
1
-
-
5
11
-
-
2
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4
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1
-
-
-
-
-
8
2
-
-
2
-
4
-
-
4
4
-
-
-
-
-
4
1
-
-
-
5
4
11
-
-
2
-
-
-
-
1
-
-
-
-
8
2
-
-
2
-
4
-
-
-
-
-
-
-
-
-
349569
Keradjopoulos
Salt-dependent conformational ...
Halobacterium salinarum
FEBS Lett.
112
183-185
1980
-
-
-
-
-
2
-
-
-
-
-
-
-
2
-
-
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-
1
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
2
-
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-
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-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
349570
Aharonowitz
Alanine dehydrogenase of the b ...
Streptomyces clavuligerus
Arch. Microbiol.
125
137-142
1980
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1
13
5
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6
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3
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3
5
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1
6
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1
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349571
Keradjopoulos
Purification and properties of ...
Halobacterium salinarum
Biochim. Biophys. Acta
570
1-10
1979
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4
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7
2
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2
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1
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6
1
3
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1
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1
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349572
Ohashima
Purification and properties of ...
Lysinibacillus sphaericus
Eur. J. Biochem.
100
29-39
1979
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1
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4
11
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2
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3
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1
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8
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1
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1
8
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3
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1
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349573
Kim
Partial purification and prope ...
Halobacterium salinarum
Biochem. J.
161
313-320
1977
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1
9
4
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5
1
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6
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3
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1
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349580
Keradjopoulos
-
Thermophilic character of enzy ...
Bacillus cereus, Bacillus cereus T, Bacillus subtilis, Halobacterium salinarum
FEMS Microbiol. Lett.
1
179-182
1977
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2
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10
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6
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4
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2
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349574
Rowell
Alanine dehydrogenase of the N ...
Anabaena cylindrica
Arch. Microbiol.
107
115-124
1976
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7
3
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1
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2
1
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3
1
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2
2
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349562
Alizade
Stereochemistry of the hydroge ...
Bacillus subtilis
Biochim. Biophys. Acta
397
5-8
1975
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12940
Nitta
L-Amino acid dehydrogenases in ...
Bacillus subtilis
J. Bacteriol.
117
588-592
1974
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2
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2
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1
1
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1
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1
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349576
Keradjopoulos
Thermophilic alanine dehydroge ...
Halobacterium salinarum
Can. J. Biochem.
52
1033-1037
1974
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1
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1
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3
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349577
McCowen
Regulation of alanine dehydrog ...
Bacillus licheniformis
J. Bacteriol.
118
590-597
1974
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3
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1
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1
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1
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349578
Graefe
Activity of alanine dehydrogen ...
Streptomyces hygroscopicus
Z. Allg. Mikrobiol.
14
181-192
1974
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1
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349585
Williamson
-
L-Alanin ...
Bacillus subtilis
Methods Enzym. Anal. , 3rd Ed. (Bergmeyer, H. U. , ed. )
2
1724-1727
1974
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1
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349564
Sulzman
Characterization of circadian ...
Euglena gracilis, Euglena gracilis Z
Biochim. Biophys. Acta
320
594-609
1973
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22
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4
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4
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1
1
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349579
Borris
Relationship of L-alanine and ...
Bacillus thuringiensis
Biochim. Biophys. Acta
191
716-718
1969
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1
-
-
-
-
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349561
Germano
Purification and properties of ...
Desulfovibrio desulfuricans
J. Bacteriol.
96
55-60
1968
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3
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349598
Berberich
-
D-Amino acids as inducers of L ...
Bacillus subtilis
J. Biol. Chem.
243
1008-1013
1968
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2
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349555
Yoshida
Enzymic properties of Alanine ...
Bacillus subtilis
Biochim. Biophys. Acta
96
248-262
1965
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1
9
18
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1
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1
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1
1
9
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1
2
2
2
2
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2
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1
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9
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18
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1
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1
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1
1
9
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1
2
2
2
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