BRENDA - Enzyme Database show
show all sequences of 1.3.99.5

5 alpha-reductase and aromatase inhibitory constituents from Brassica rapa L. pollen

Li, Y.H.; Yang, Y.F.; Li, K.; Jin, L.L.; Yang, N.Y.; Kong, D.Y.; Chem. Pharm. Bull. 57, 401-404 (2009)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
linolenic acid
strong inhibition
Rattus norvegicus
Monolinolein
strong inhibition
Rattus norvegicus
additional information
screening of biologically active constituents from Brassica rapa pollen in supercritical CO2 fluid extract, overview. No inhibition by 24-methylenecholesterol linolenate, cycloeucalenol linolenate, 24-methylenecholesterol palmitate, cycloeucalenol, pollinastanol, 24-methylenecholesterol, palmitic acid, and monopalmitin
Rattus norvegicus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
microsome
-
Rattus norvegicus
-
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
dihydrotestosterone + NADP+
Rattus norvegicus
the enzyme performs conversion of testosterone to dihydrotestosterone
testosterone + NADPH + H+
-
-
r
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Rattus norvegicus
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
liver
-
Rattus norvegicus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
dihydrotestosterone + NADP+
-
711736
Rattus norvegicus
testosterone + NADPH + H+
-
-
-
r
dihydrotestosterone + NADP+
the enzyme performs conversion of testosterone to dihydrotestosterone
711736
Rattus norvegicus
testosterone + NADPH + H+
-
-
-
r
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
linolenic acid
strong inhibition
Rattus norvegicus
Monolinolein
strong inhibition
Rattus norvegicus
additional information
screening of biologically active constituents from Brassica rapa pollen in supercritical CO2 fluid extract, overview. No inhibition by 24-methylenecholesterol linolenate, cycloeucalenol linolenate, 24-methylenecholesterol palmitate, cycloeucalenol, pollinastanol, 24-methylenecholesterol, palmitic acid, and monopalmitin
Rattus norvegicus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
microsome
-
Rattus norvegicus
-
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
dihydrotestosterone + NADP+
Rattus norvegicus
the enzyme performs conversion of testosterone to dihydrotestosterone
testosterone + NADPH + H+
-
-
r
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
liver
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
dihydrotestosterone + NADP+
-
711736
Rattus norvegicus
testosterone + NADPH + H+
-
-
-
r
dihydrotestosterone + NADP+
the enzyme performs conversion of testosterone to dihydrotestosterone
711736
Rattus norvegicus
testosterone + NADPH + H+
-
-
-
r
Other publictions for EC 1.3.99.5
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
740834
Kim
-
Inhibitory effect of curcuma l ...
Homo sapiens, Rattus norvegicus
J. Korean Soc. Food Sci. Nutr.
43
318-322
2014
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2
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2
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2
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740982
Li
Steroid 5-alpha-reductase type ...
Homo sapiens
Mol. Biol. Rep.
40
3597-3608
2013
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-
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2
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1
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1
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1
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725483
van Oosterwijk
Structure and catalytic mechan ...
Rhodococcus jostii
J. Biol. Chem.
287
30975-30983
2012
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1
7
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3
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1
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1
7
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3
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1
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3
-
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3
3
710704
Szécsi
Determination of rat 5alpha-re ...
Rattus norvegicus
Acta Biol. Hung.
61
274-281
2010
-
-
-
-
-
-
7
-
-
-
-
-
-
2
-
-
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1
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1
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7
-
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7
7
-
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1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
712093
Cohen
Testosterone selectively affec ...
Anolis carolinensis
Gen. Comp. Endocrinol.
166
128-133
2010
1
-
-
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
2
-
-
4
-
-
-
-
-
-
-
-
-
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-
1
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2
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-
-
2
-
-
4
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
712094
Ramos
Cloning and differential expre ...
Mesocricetus auratus
Gen. Comp. Endocrinol.
166
388-395
2010
-
-
1
-
-
-
-
1
-
-
-
1
-
3
-
-
-
-
-
3
-
-
2
-
-
-
-
-
2
-
-
2
-
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-
-
-
2
2
-
-
-
-
-
-
1
-
-
-
1
-
-
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-
-
4
-
-
2
-
-
-
-
-
2
-
-
-
1
1
2
1
-
-
712095
Langlois
Evolution of steroid-5alpha-re ...
Canis lupus familiaris, Danio rerio, Gallus gallus, Homo sapiens, Mus musculus, Rattus norvegicus, Xenopus tropicalis
Gen. Comp. Endocrinol.
166
489-497
2010
-
-
7
-
-
-
23
1
-
-
-
-
-
8
-
-
-
-
-
4
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
7
-
-
-
-
-
23
-
1
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
3
-
-
-
-
7
7
-
-
-
712124
Ko
Clinical characterization and ...
Homo sapiens
Horm. Res. Paediatr.
73
41-48
2010
-
-
1
-
3
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
3
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-
-
-
-
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-
-
-
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-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
712125
Walter
Difficulties in diagnosis and ...
Homo sapiens
Horm. Res. Paediatr.
74
67-71
2010
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
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-
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-
-
-
-
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-
-
1
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-
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-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
713449
Gupta
Inhibition of 5alpha-reductase ...
Homo sapiens
Prostate
70
1575-1585
2010
-
-
-
-
-
-
2
-
-
-
-
-
-
4
-
-
-
-
-
2
-
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2
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2
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-
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-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
713519
Aggarwal
An overview on 5alpha-reductas ...
Homo sapiens, Rattus norvegicus
Steroids
75
109-153
2010
-
-
-
-
-
-
417
-
2
-
-
2
-
4
-
-
-
-
-
9
-
-
4
-
-
-
-
-
-
-
-
2
27
-
347
-
-
-
4
-
-
-
403
740
32
-
3
-
-
2
-
-
-
-
-
10
-
-
4
-
-
-
-
-
-
-
-
-
-
1
2
-
-
-
713520
Aggarwal
Self-organizing molecular fiel ...
Homo sapiens
Steroids
75
411-418
2010
-
-
-
-
-
-
32
2
1
-
-
1
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
2
-
-
30
-
-
-
2
-
-
-
30
32
-
2
1
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
713595
Wang
Establishment of a novel model ...
Homo sapiens
Yakugaku Zasshi
130
1207-1214
2010
-
-
1
-
-
-
5
1
-
-
-
1
-
2
-
-
1
-
-
-
-
-
2
-
1
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
1
5
-
1
-
-
-
1
-
-
-
1
-
-
-
-
2
-
1
-
-
-
1
-
-
-
-
1
1
-
-
-
711658
Paz-y-Min
Association among polymorphism ...
Homo sapiens
Cancer Genet. Cytogenet.
189
71-76
2009
-
-
1
-
2
-
-
-
-
-
-
-
-
2
-
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1
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2
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-
-
-
-
-
-
-
-
711736
Li
5 alpha-reductase and aromatas ...
Rattus norvegicus
Chem. Pharm. Bull.
57
401-404
2009
-
-
-
-
-
-
3
-
1
-
-
1
-
1
-
-
-
-
-
1
-
-
2
-
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-
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-
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3
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1
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1
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1
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2
-
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-
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-
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-
711937
Seo
Regulation of steroid 5-alpha ...
Mus musculus
Exp. Cell Res.
315
3133-3139
2009
-
-
1
-
-
-
-
-
1
-
-
-
-
3
-
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-
-
-
3
-
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1
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1
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3
-
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-
-
-
-
-
-
-
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-
1
2
2
1
-
-
713080
Kim
Synthesis of pregnane derivati ...
Homo sapiens
Molecules
14
4655-4668
2009
-
-
-
-
-
-
16
-
-
-
-
1
-
1
-
-
-
-
-
3
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
16
-
-
-
-
-
1
-
-
-
-
-
3
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
713447
Thomas
Overexpression of 5alpha-reduc ...
Homo sapiens
Prostate
69
595-602
2009
-
-
1
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
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-
-
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1
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-
3
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
2
4
-
-
-
687319
Baldinotti
Molecular characterization of ...
Homo sapiens
J. Androl.
29
20-28
2008
-
-
-
-
6
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
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6
-
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2
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-
688720
Amory
The effect of 5alpha-reductase ...
Homo sapiens
J. Urol.
179
2333-2338
2008
-
-
-
-
-
-
2
-
-
-
-
1
-
2
-
-
-
-
-
3
-
-
1
-
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-
-
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2
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1
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-
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3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
699215
Signorelli
Polymorphisms of steroid 5-alp ...
Homo sapiens
J. Endocrinol. Invest.
31
1092-1097
2008
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
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-
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-
-
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-
-
-
-
-
-
-
-
-
684794
Lu
Changes in aortic endothelium ...
Rattus norvegicus
Asian J. Androl.
9
843-847
2007
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
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1
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-
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-
-
-
-
-
-
-
-
-
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-
687017
Verdi
Finasteride, a 5alpha-reductas ...
Rattus norvegicus
Horm. Behav.
51
605-610
2007
1
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
1
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1
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1
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1
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668021
Park Jun-Seon
Enzymatic hydrolysis of green ...
Homo sapiens
Biosci. Biotechnol. Biochem.
70
387-394
2006
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1
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668300
Skalba
Content of 5-alpha-reductase ( ...
Homo sapiens
Clin. Exp. Dermatol.
31
564-570
2006
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1
-
-
-
-
-
-
-
-
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1
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1
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1
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1
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-
-
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-
-
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-
-
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-
-
-
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-
668682
Kim Sung Hoo
A novel frameshift mutation in ...
Homo sapiens
Fertil. Steril.
85(750)
e9-e12
2006
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1
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-
1
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-
-
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2
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1
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1
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668960
Elzanaty
Significant impact of 5alpha-r ...
Homo sapiens
Int. J. Androl.
29
414-420
2006
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1
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2
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1
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1
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1
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1
-
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669624
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Variants in the 5alpha-reducta ...
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91
4085-4091
2006
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3
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1
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1
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1
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669811
Salem
Novel 5alpha-reductase inhibit ...
Homo sapiens, Rattus norvegicus
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2006
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2
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3
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20
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2
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3
-
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670266
Robaire
Actions of 5alpha-reductase in ...
Rattus norvegicus
Mol. Cell. Endocrinol.
250
190-195
2006
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3
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2
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1
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1
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670694
Agis-Balboa
Characterization of brain neur ...
Mus musculus
Proc. Natl. Acad. Sci. USA
103
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2006
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1
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670738
Gleave
The effects of the dual 5alpha ...
Homo sapiens
Prostate
66
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2006
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1
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1
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740177
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Enzymatic hydrolysis of green ...
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2006
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1
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2
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1
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2
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1
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662726
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Quantitative appreciation of s ...
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2
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3
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2
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668281
Titus
Steroid 5alpha-reductase isozy ...
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2005
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1
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1
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669566
Festuccia
Effects of 5 alpha reductase i ...
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J. Cancer Res. Clin. Oncol.
131
243-254
2005
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1
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670032
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1
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3
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655346
Torres
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4
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1
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1
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655739
Torres
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1
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657354
Woelfling
Neighboring group participatio ...
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7
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1
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1
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7
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7
7
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1
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655526
Torres
Differential regulation of ste ...
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712201
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In vitro inhibition of testicu ...
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Farkash
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