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Literature summary for 1.3.99.5 extracted from
- Finasteride, a 5alpha-reductase inhibitor, potentiates antinociceptive effects of morphine, prevents the development of morphine tolerance and attenuates abstinence behavior in the rat (2007), Horm. Behav., 51, 605-610.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| morphine | morphine increases 5alpha-reductase enzyme activity in the central nervous system | Rattus norvegicus |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| finasteride | 5mg/kg, chronic finasteride administration effectively blocks development of tolerance and dependence to morphine | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|
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Release 2023.1 (January 2023)
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