Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of RetSat-/- mice, phenotype in comparison to wild-type mice, overview | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(R)-all-trans-13,14-dihydroretinol + acceptor | Mus musculus | retinol saturase catalyzes the saturation of all-trans-retinol to produce (R)-all-trans-13,14-dihydroretinol | all-trans-retinol + reduced acceptor | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
C57BL/6 mice | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(R)-all-trans-13,14-dihydroretinol + acceptor | retinol saturase catalyzes the saturation of all-trans-retinol to produce (R)-all-trans-13,14-dihydroretinol | Mus musculus | all-trans-retinol + reduced acceptor | - |
r |
Synonyms | Comment | Organism |
---|---|---|
retinol saturase | - |
Mus musculus |
RetSat | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
additional information | RetSat deficiency leads to up-regulation of PPARgamma and PPARgamma target expression | Mus musculus |
physiological function | RetSat is required for adipocyte differentiation in the 3T3-L1 cell culture model, analysis of the mechanism involved in this putative proadipogenic effect of RetSat, overview. RetSat-null mice have normal levels of retinol and retinyl palmitate in liver, serum, and adipose tissue, but, in contrast to wild-type mice, are deficient in the production of all-trans-13,14-dihydroretinol from dietary vitamin A. Despite accumulating more fat, RetSat-null mice maintained on either low-fat or high-fat diets gain weight and have similar rates of food intake as age- and gender-matched wild-type control littermates, ablation of RetSat does not result in alterations in total body weight gain but could still affect the relative composition and size of adipose stores, phenotype, overview | Mus musculus |