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Literature summary for 1.3.98.5 extracted from

  • Lobo, S.; Scott, A.; Videira, M.; Winpenny, D.; Gardner, M.; Palmer, M.; Schroeder, S.; Lawrence, A.; Parkinson, T.; Warren, M.; Saraiva, L.
    Staphylococcus aureus haem biosynthesis Characterisation of the enzymes involved in final steps of the pathway (2015), Mol. Microbiol., 97, 472-487 .
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Staphylococcus aureus

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus A0A0S3DY11
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Fe-coproporphyrin III + 2 H2O2
-
Staphylococcus aureus protoheme + 2 CO2 + 4 H2O
-
?
additional information in the absence of H2O2, HemQ converts only around 1% of Fe-coproporphyrin III into protoheme IX Staphylococcus aureus ?
-
?

Synonyms

Synonyms Comment Organism
HemQ
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Staphylococcus aureus

Cofactor

Cofactor Comment Organism Structure
heme the presence of a heme cofactor bound to the enzyme does not seem to modify the biochemical and enzymatic properties of HemQ Staphylococcus aureus

General Information

General Information Comment Organism
physiological function enzymes HemY, HemH and HemQ act as a coproporphyrinogen III oxidase, coproporphyrin III ferrochelatase and Fe-coproporphyrin III oxidase/dehydrogenase Staphylococcus aureus