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Literature summary for 1.3.8.7 extracted from

  • Finocchiaro, G.; Ito, M.; Tanaka, K.
    Purification and properties of short chain acyl-CoA, medium chain acyl-CoA, and isovaleryl-CoA dehydrogenases from human liver (1987), J. Biol. Chem., 262, 7982-7989.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(methylenecyclopropyl)acetyl-CoA 0.01 mM, 95% inhibition Homo sapiens
(R)-(-)-(methylenecyclopropyl)acetyl-CoA
-
Homo sapiens
iodoacetamide 2 mM, 73% inhibition Homo sapiens
N-ethylmaleimide 2 mM, 43% inhibition Homo sapiens
p-chloromercuribenzoate 0.1 mM, 17% inhibition Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0034
-
electron transfer flavoprotein
-
Homo sapiens
0.00714
-
butyryl-CoA
-
Homo sapiens
0.008
-
hexanoyl-CoA
-
Homo sapiens
0.0091
-
decanoyl-CoA
-
Homo sapiens
0.01
-
tetradecenoyl-CoA
-
Homo sapiens
0.0216
-
hexanoyl-CoA
-
Homo sapiens
0.023
-
palmitoyl-CoA
-
Homo sapiens
0.0563
-
valeryl-CoA
-
Homo sapiens
1.67
-
phenazine methosulfate
-
Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
44000
-
4 * 44000, SDS-PAGE Homo sapiens
178000
-
gel filtration Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
6.75
-
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-CoA + acceptor electron acceptor: phenazine methosulfate Homo sapiens 2,3-dehydroacyl-CoA + reduced acceptor
-
?
acyl-CoA + acceptor chain-length specificity depending on electron acceptor: with phenazine methosulfate hexanoyl-CoA, with electron transfer flavoprotein, octanoyl-CoA Homo sapiens 2,3-dehydroacyl-CoA + reduced acceptor
-
?
acyl-CoA + acceptor intermediary electron acceptor: 2,6-dichloroindophenol Homo sapiens 2,3-dehydroacyl-CoA + reduced acceptor
-
?
acyl-CoA + acceptor final electron acceptor: 8-dimethylamino-2,3-benzophenoxazinium chloride, trivial name meldola's blue Homo sapiens 2,3-dehydroacyl-CoA + reduced acceptor
-
?
butanoyl-CoA + acceptor
-
Homo sapiens crotonyl-CoA + reduced acceptor
-
?
decanoyl-CoA + acceptor acceptors: phenazine methosulfate or electron transferring flavoprotein Homo sapiens 2-decenoyl-CoA + reduced acceptor
-
?
dodecanoyl-CoA + acceptor acceptors: phenazine methosulfate or electron transferring flavoprotein Homo sapiens 2-dodecenoyl-CoA + reduced acceptor
-
?
hexadecanoyl-CoA + acceptor acceptors: phenazine methosulfate or electron transferring flavoprotein, very low activity Homo sapiens 2-hexadecenoyl-CoA + reduced acceptor
-
?
hexanoyl-CoA + acceptor acceptors: phenazine methosulfate or electron transferring flavoprotein, best substrate with phenazine methosulfate Homo sapiens 2-hexenoyl-CoA + reduced acceptor
-
?
n-octanoyl-CoA + phenazine methosulfate + 2,6-dichloroindophenol best substrate with electron transferring flavoprotein Homo sapiens 2-octenoyl-CoA + reduced acceptor
-
?
octadecanoyl-CoA + acceptor acceptors: phenazine methosulfate or electron transferring flavoprotein, extremely low activity Homo sapiens 2-octadecenoyl-CoA + reduced acceptor
-
?
pentanoyl-CoA + acceptor acceptors: phenazine methosulfate or electron transferring flavoprotein Homo sapiens 2-pentenoyl-CoA + reduced acceptor
-
?
tetradecanoyl-CoA + acceptor acceptors: phenazine methosulfate or electron transferring flavoprotein, low activity Homo sapiens 2-tetradecenoyl-CoA + reduced acceptor
-
?
tetradecenoyl-CoA + reduced electron transfer flavoprotein
-
Homo sapiens tetradecanoyl-CoA + electron transfer flavoprotein
-
r

Subunits

Subunits Comment Organism
tetramer 4 * 44000, SDS-PAGE Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
-
Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
6 9.5
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD
-
Homo sapiens