Protein Variants | Comment | Organism |
---|---|---|
E370D | mutant is more sensitive against inactivation by 3-thiaglutaryl-CoA compared to the wild-type enzyme, irreversible inactivation | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-pentynoyl-CoA | mechanism-based inactivation, inhibition kinetics | Homo sapiens | |
3-thiaglutaryl-CoA | non-oxidizable analogue, which competes with 2-pentynoyl-CoA for the binding site | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | reaction and inhibition kinetics | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q92947 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
glutaryl-CoA + 2,6-dichlorophenol indophenol | - |
Homo sapiens | crotonoyl-CoA + CO2 + reduced 2,6-dichlorophenol indophenol | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GCD | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.6 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
flavin | - |
Homo sapiens | |
additional information | electron acceptor: 2,6-dichlorophenol indophenol | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0069 | - |
3-thiaglutaryl-CoA | pH 7.6, 25°C | Homo sapiens | |
0.0228 | - |
3-thiaglutaryl-CoA | pH 7.6, 25°C | Homo sapiens |