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Literature summary for 1.3.8.4 extracted from

  • Reinard, T.; Janke, V.; Willard, J.; Buck, F.; Jacobsen, H.J.; Vockley, J.
    Cloning of a gene for an acyl-CoA dehydrogenase from Pisum sativum L. and purification and characterization of its product as an isovaleryl-CoA dehydrogenase (2000), J. Biol. Chem., 275, 33738-33743.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
at the amino acid level, pea enzyme is 60% similar to human and rat enzyme Pisum sativum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0042
-
isovaleryl-CoA purified enzyme Pisum sativum
0.006
-
isovaleryl-CoA partially purified enzyme Pisum sativum
0.0748
-
n-valeryl-CoA partially purified enzyme Pisum sativum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
isovaleryl-CoA + acceptor Pisum sativum
-
3-methylcrotonyl-CoA + reduced acceptor
-
?
additional information Pisum sativum Glu-244 is the catalytic base responsible for abstracting the alpha-proton of substrate ?
-
?

Organism

Organism UniProt Comment Textmining
Pisum sativum
-
-
-

Purification (Commentary)

Purification (Comment) Organism
using auxin affinity chromatography matrix Pisum sativum

Source Tissue

Source Tissue Comment Organism Textmining
seed
-
Pisum sativum
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.03
-
partially purified enzyme, substrate: n-valeryl-CoA Pisum sativum
0.3
-
partially purified enzyme, substrate: isovaleryl-CoA Pisum sativum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
isovaleryl-CoA + acceptor
-
Pisum sativum 3-methylcrotonyl-CoA + reduced acceptor
-
?
isovaleryl-CoA + acceptor isovaleryl-CoA is the preferred substrate Pisum sativum 3-methylcrotonyl-CoA + reduced acceptor
-
?
additional information Glu-244 is the catalytic base responsible for abstracting the alpha-proton of substrate Pisum sativum ?
-
?
n-valeryl-CoA + acceptor
-
Pisum sativum pent-2-enoyl-CoA + reduced acceptor
-
?