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Literature summary for 1.3.8.4 extracted from

  • Finocchiaro, G.; Ito, M.; Tanaka, K.
    Purification and properties of short chain acyl-CoA, medium chain acyl-CoA, and isovaleryl-CoA dehydrogenases from human liver (1987), J. Biol. Chem., 262, 7982-7989.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(methylenecyclopropyl)acetyl-CoA at 0.001 mM 21% activity remains; at 0.01 mM 3% activity remains Homo sapiens
iodoacetamide at 2 mM 19% activity remains Homo sapiens
Methylmercury iodide
-
Homo sapiens
N-ethylmaleimide at 2 mM 64% activity remains Homo sapiens
p-chloromercuribenzoate at 0.1 mM 18% activity remains Homo sapiens
p-hydroxymercuribenzoate
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0038
-
electron-transfer flavoprotein
-
Homo sapiens
0.014
-
isovaleryl-CoA
-
Homo sapiens
0.0167
-
valeryl-CoA
-
Homo sapiens
0.0167 0.4 n-valeryl-CoA
-
Homo sapiens
0.02
-
hexanoyl-CoA
-
Homo sapiens
0.025
-
butyryl-CoA
-
Homo sapiens
0.833
-
phenazine methosulfate
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Homo sapiens 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
42000
-
4 * 42000, SDS-PAGE Homo sapiens
172000
-
gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
isovaleryl-CoA + acceptor Homo sapiens
-
3-methylcrotonyl-CoA + reduced acceptor
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
using ammonium sulfate fractionation followed by DEAE-Sephadex A-50, hydroxyapatite, Matrex Gel Blue A, agarose-hexane-CoA, and Bio-Gel A-0.5 column chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.01
-
propionyl-CoA as substrate and phenazine methosulfate as acceptor or hexanoyl-CoA as substrate and 0.0056 mM electron transfer flavoprotein as acceptor Homo sapiens
0.03
-
butyryl-CoA as substrate and 0.0056 mM electron transfer flavoprotein as acceptor Homo sapiens
0.09
-
valeryl-CoA as substrate and 0.0056 mM electron transfer flavoprotein as acceptor Homo sapiens
0.17
-
S-2-methylbutyryl-CoA as substrate and phenazine methosulfate as acceptor Homo sapiens
0.51
-
butyryl-CoA as substrate and phenazine methosulfate as acceptor Homo sapiens
0.53
-
isovaleryl-CoA as substrate and 0.0056 mM electron transfer flavoprotein as acceptor Homo sapiens
0.64
-
hexanoyl-CoA as substrate and phenazine methosulfate as acceptor Homo sapiens
0.72
-
isovaleryl-CoA as substrate and 0.012 mM electron transfer flavoprotein as acceptor Homo sapiens
1.09
-
valeryl-CoA as substrate and phenazine methosulfate as acceptor Homo sapiens
2.91
-
isovaleryl-CoA as substrate and phenazine methosulfate as acceptor Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
butyryl-CoA + acceptor acceptor: phenazine methosulfate Homo sapiens but-2-enoyl-CoA + reduced acceptor
-
?
hexanoyl-CoA + acceptor acceptor: phenazine methosulfate Homo sapiens hex-2-enoyl-CoA + reduced acceptor
-
?
isovaleryl-CoA + acceptor
-
Homo sapiens 3-methylcrotonyl-CoA + reduced acceptor
-
?
isovaleryl-CoA + acceptor acceptors: electron-transfer flavoprotein, phenazine methosulfate Homo sapiens 3-methylcrotonyl-CoA + reduced acceptor
-
?
isovaleryl-CoA + electron-transfer flavoprotein
-
Homo sapiens 3-methylcrotonyl-CoA + reduced electron-transfer flavoprotein
-
r
isovaleryl-CoA + phenazine methosulfate
-
Homo sapiens 3-methylcrotonyl-CoA + reduced phenazine methosulfate
-
?

Subunits

Subunits Comment Organism
tetramer 4 * 42000, SDS-PAGE Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
isovaleryl-CoA + phenazine methosulfate Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD 1 mol of FAD per subunit Homo sapiens