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Literature summary for 1.3.8.2 extracted from

  • Li, B.; Ni, S.; Mao, F.; Chen, F.; Liu, Y.; Wei, H.; Chen, W.; Zhu, J.; Lan, L.; Li, J.
    Novel terminal biphenyl-based diapophytoene desaturases (CrtN) inhibitors as anti-MRSA/VISR/LRSA agents with reduced hERG activity (2018), J. Med. Chem., 61, 224-250 .
    View publication on PubMed

Application

Application Comment Organism
drug development the enzyme CrtN is an attractive and druggable target for fighting pigmented Staphylococcus aureus infections Staphylococcus aureus
medicine the enzyme CrtN is an attractive and druggable target for fighting pigmented Staphylococcus aureus infections Staphylococcus aureus

Cloned(Commentary)

Cloned (Comment) Organism
recombinant expression of His-tagged enzyme Staphylococcus aureus

Inhibitors

Inhibitors Comment Organism Structure
(2E)-N-ethyl-N-[(1H-indol-7-yl)methyl]-3-[4-(trifluoromethyl)phenyl]prop-2-en-1-amine
-
Staphylococcus aureus
(2E)-N-[(1H-indol-7-yl)methyl]-3-(3-methoxyphenyl)-N-methylprop-2-en-1-amine
-
Staphylococcus aureus
(2E)-N-[(1H-indol-7-yl)methyl]-3-[4-(trifluoromethyl)phenyl]prop-2-en-1-amine
-
Staphylococcus aureus
(2E)-N-[(1H-indol-7-yl)methyl]-N-(propan-2-yl)-3-[4-(trifluoromethyl)phenyl]prop-2-en-1-amine
-
Staphylococcus aureus
(2E,4E)-5-([1,1'-biphenyl]-4-yl)-N-(benzofuran-3-ylmethyl)-N-methylpenta-2,4-dien-1-amine
-
Staphylococcus aureus
(2E,4E)-N-((1H-indol-7-yl)methyl)-5-([1,1'-biphenyl]-4-yl)-N-methylpenta-2,4-dien-1-amine
-
Staphylococcus aureus
(E)-3-([1,1'-biphenyl]-4-yl)-N-(benzofuran-3-ylmethyl)-N,2-dimethylprop-2-en-1-amine
-
Staphylococcus aureus
(E)-3-([1,1'-biphenyl]-4-yl)-N-(benzofuran-3-ylmethyl)-N-methylprop-2-en-1-amine
-
Staphylococcus aureus
(E)-4-(3-(((1H-indol-7-yl)methyl)(methyl)amino)prop-1-en-1-yl)benzonitrile
-
Staphylococcus aureus
(E)-4-(3-((benzofuran-3-ylmethyl)(methyl)amino)prop-1-en-1-yl)benzonitrile
-
Staphylococcus aureus
(E)-4-([1,1'-biphenyl]-4-yl)-N-(benzofuran-3-ylmethyl)-N-methylbut-3-en-1-amine
-
Staphylococcus aureus
(E)-N-((1H-indol-2-yl)methyl)-N-methyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-((1H-indol-3-yl)methyl)-N-methyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-((1H-indol-4-yl)methyl)-N-methyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-((1H-indol-5-yl)methyl)-N-methyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-((1H-indol-6-yl)methyl)-N-methyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-((1H-indol-7-yl)methyl)-3-(2,4-dichlorophenyl)-N-methylprop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-((1H-indol-7-yl)methyl)-3-(2-chlorophenyl)-N-methylprop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-((1H-indol-7-yl)methyl)-3-(2-fluoro-4-(trifluoromethyl)-phenyl)-N-methylprop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-((1H-indol-7-yl)methyl)-3-(2-fluoro-4-methoxyphenyl)-N-methylprop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-((1H-indol-7-yl)methyl)-3-(2-fluorophenyl)-N-methylprop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-((1H-indol-7-yl)methyl)-3-(2-methoxyphenyl)-N-methylprop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-((1H-indol-7-yl)methyl)-3-(3-chlorophenyl)-N-methylprop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-((1H-indol-7-yl)methyl)-3-(3-fluoro-4-(trifluoromethyl)-phenyl)-N-methylprop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-((1H-indol-7-yl)methyl)-3-(3-fluoro-4-methoxyphenyl)-N-methylprop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-((1H-indol-7-yl)methyl)-3-(3-fluorophenyl)-N-methylprop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-((1H-indol-7-yl)methyl)-3-(4-(difluoromethyl)phenyl)-N-methylprop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-((1H-indol-7-yl)methyl)-3-(4-(tert-butyl)phenyl)-N-methylprop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-((1H-indol-7-yl)methyl)-3-(4-bromophenyl)-N-methylprop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-((1H-indol-7-yl)methyl)-3-(4-chlorophenyl)-N-methylprop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-((1H-indol-7-yl)methyl)-3-(4-ethoxyphenyl)-N-methylprop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-((1H-indol-7-yl)methyl)-3-(4-fluorophenyl)-N-methylprop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-((1H-indol-7-yl)methyl)-3-(4-methoxyphenyl)-N-methylprop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-((1H-indol-7-yl)methyl)-3-(furan-2-yl)-N-methylprop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-((1H-indol-7-yl)methyl)-3-([1,1'-biphenyl]-4-yl)-N,2-dimethylprop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-((1H-indol-7-yl)methyl)-3-([1,1'-biphenyl]-4-yl)-N-methylprop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-((1H-indol-7-yl)methyl)-3-cyclohexyl-N-methylprop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-((1H-indol-7-yl)methyl)-3-cyclopentyl-N-methylprop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-((1H-indol-7-yl)methyl)-4-([1,1'-biphenyl]-4-yl)-N-methylbut-3-en-1-amine
-
Staphylococcus aureus
(E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(2-(trifluoromethyl)phenyl)prop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(2-nitrophenyl)-prop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(3-(trifluoromethyl)phenyl)prop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(3-nitrophenyl)-prop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(4-nitrophenyl)-prop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(m-tolyl)prop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(naphthalen-1-yl)-prop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(naphthalen-2-yl)-prop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(o-tolyl)prop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(p-tolyl)prop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(thiophen-2-yl)-prop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-phenylprop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-((1H-indol-7-yl)methyl)-N-methylbut-2-en-1-amine
-
Staphylococcus aureus
(E)-N-((3a,7a-dihydrobenzofuran-3-yl)methyl)-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-((3a,7a-dihydrobenzofuran-3-yl)methyl)-N-ethyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-((3a,7a-dihydrobenzofuran-3-yl)methyl)-N-isopropyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-(benzofuran-2-ylmethyl)-N-methyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-(benzofuran-3-ylmethyl)-3-(2,4-dichlorophenyl)-Nmethylprop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-(benzofuran-3-ylmethyl)-3-(2-chlorophenyl)-N-methylprop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-(benzofuran-3-ylmethyl)-3-(2-fluoro-4-(trifluoromethyl)phenyl)-N-methylprop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-(benzofuran-3-ylmethyl)-3-(2-fluoro-4-methoxyphenyl)-N-methylprop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-(benzofuran-3-ylmethyl)-3-(2-fluorophenyl)-N-methylprop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-(benzofuran-3-ylmethyl)-3-(2-methoxyphenyl)-N-methylprop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-(benzofuran-3-ylmethyl)-3-(3-chlorophenyl)-N-methylprop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-(benzofuran-3-ylmethyl)-3-(3-fluoro-4-(trifluoromethyl)phenyl)-N-methylprop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-(benzofuran-3-ylmethyl)-3-(3-fluoro-4-methoxyphenyl)-N-methylprop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-(benzofuran-3-ylmethyl)-3-(3-fluorophenyl)-N-methylprop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-(benzofuran-3-ylmethyl)-3-(3-methoxyphenyl)-N-methylprop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-(benzofuran-3-ylmethyl)-3-(4-(difluoromethyl)phenyl)-N-methylprop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-(benzofuran-3-ylmethyl)-3-(4-(tert-butyl)phenyl)-N-methylprop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-(benzofuran-3-ylmethyl)-3-(4-bromophenyl)-N-methylprop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-(benzofuran-3-ylmethyl)-3-(4-chlorophenyl)-N-methylprop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-(benzofuran-3-ylmethyl)-3-(4-ethoxyphenyl)-N-methylprop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-(benzofuran-3-ylmethyl)-3-(4-fluorophenyl)-N-methylprop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-(benzofuran-3-ylmethyl)-3-(furan-2-yl)-N-methylprop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-(benzofuran-3-ylmethyl)-3-cyclohexyl-N-methylprop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-(benzofuran-3-ylmethyl)-3-cyclohexyl-N-methyprop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-(benzofuran-3-ylmethyl)-3-cyclopentyl-N-methylprop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-(benzofuran-3-ylmethyl)-3-cyclopentyl-N-methyprop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-(benzofuran-3-ylmethyl)-N-methyl-2-en-1-amine
-
Staphylococcus aureus
(E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(2-(trifluoromethyl)phenyl)prop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(2-nitrophenyl)-prop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(3-(trifluoromethyl)phenyl)prop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(3-nitrophenyl)-prop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(4-nitrophenyl)-prop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(m-tolyl)prop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(naphthalen-1-yl)prop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(naphthalen-2-yl)prop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(o-tolyl)prop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(p-tolyl)prop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(thiophen-2-yl)-prop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-phenylprop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-(benzo[b]thiophen-2-ylmethyl)-N-methyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine
-
Staphylococcus aureus
(E)-N-(benzo[b]thiophen-3-ylmethyl)-N-methyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine
-
Staphylococcus aureus
3-([1,1'-biphenyl]-4-yl)-N-(benzofuran-3-ylmethyl)-N-methylprop-2-yn-1-amine
-
Staphylococcus aureus
3-([1,1'-biphenyl]-4-yl)-N-(benzofuran-3-ylmethyl)-N-methylpropan-1-amine
-
Staphylococcus aureus
linezolid
-
Staphylococcus aureus
methyl (E)-4-(3-(((1H-indol-7-yl)methyl)(methyl)amino)prop-1-en-1-yl)benzoate
-
Staphylococcus aureus
methyl (E)-4-(3-((benzofuran-3-ylmethyl)(methyl)amino)-prop-1-en-1-yl)benzoate
-
Staphylococcus aureus
methyl(E)-4-(3-((benzofuran-3-ylmethyl)(methyl)amino)-prop-1-en-1-yl)benzoate
-
Staphylococcus aureus
additional information synthesis of a series of CrtN inhibitors with other scaffolds, method overview. The compounds show excellent activity against different MRSA in in vitro and in vivo at a lower dosage but also overcome the disadvantages of hERG inhibition. Linezolid and vancomycin, the last-resort antimicrobial agents, are introduced as positive control drugs into a murine model of Staphylococcus aureus abscess formation to evaluate the effectiveness of the analogues. Diapophytoene desaturase inhibitors for the treatment of methicillin-, vancomycin- and linezolid-resistant Staphylococcus aureus infections, cytotoxicity analysis using Hep-G2 and HEK-293T cells and BALB-C mice, in vitro pigment inhibitory activities, in vivo cytotoxicity IC50 values and pigment inhibition activity IC50 values, overview Staphylococcus aureus
N-((1H-indol-7-yl)methyl)-3-([1,1'-biphenyl]-4-yl)-N-methylprop-2-yn-1-amine
-
Staphylococcus aureus
N-((1H-indol-7-yl)methyl)-3-([1,1'-biphenyl]-4-yl)-N-methylpropan-1-amine
-
Staphylococcus aureus
Vancomycin
-
Staphylococcus aureus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
15-cis-4,4'-diapophytoene + 4 FAD Staphylococcus aureus overall reaction all-trans-4,4'-diapolycopene + 4 FADH2
-
?
15-cis-4,4'-diapophytoene + 4 FAD Staphylococcus aureus Newman overall reaction all-trans-4,4'-diapolycopene + 4 FADH2
-
?

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus O07855
-
-
Staphylococcus aureus Newman O07855
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
15-cis-4,4'-diapophytoene + 4 FAD overall reaction Staphylococcus aureus all-trans-4,4'-diapolycopene + 4 FADH2
-
?
15-cis-4,4'-diapophytoene + 4 FAD overall reaction Staphylococcus aureus Newman all-trans-4,4'-diapolycopene + 4 FADH2
-
?

Synonyms

Synonyms Comment Organism
CrtN
-
Staphylococcus aureus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at, recombinant enzyme Staphylococcus aureus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at, recombinant enzyme Staphylococcus aureus

Cofactor

Cofactor Comment Organism Structure
FAD
-
Staphylococcus aureus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000002
-
pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-3-([1,1'-biphenyl]-4-yl)-N-(benzofuran-3-ylmethyl)-N-methylprop-2-en-1-amine
0.0000025
-
pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-(benzofuran-3-ylmethyl)-3-(4-bromophenyl)-N-methylprop-2-en-1-amine
0.0000033
-
pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-((1H-indol-7-yl)methyl)-3-([1,1'-biphenyl]-4-yl)-N-methylprop-2-en-1-amine
0.0000049
-
pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-(benzofuran-3-ylmethyl)-3-(4-chlorophenyl)-N-methylprop-2-en-1-amine
0.0000062
-
pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-(benzofuran-3-ylmethyl)-3-(2,4-dichlorophenyl)-Nmethylprop-2-en-1-amine
0.0000064
-
pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-(benzofuran-3-ylmethyl)-3-(4-(difluoromethyl)phenyl)-N-methylprop-2-en-1-amine
0.0000064
-
pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(naphthalen-2-yl)prop-2-en-1-amine
0.0000092
-
pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-(benzofuran-3-ylmethyl)-3-(2-fluoro-4-(trifluoromethyl)phenyl)-N-methylprop-2-en-1-amine
0.0000095
-
pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(4-nitrophenyl)-prop-2-en-1-amine
0.0000095
-
pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus methyl (E)-4-(3-((benzofuran-3-ylmethyl)(methyl)amino)-prop-1-en-1-yl)benzoate
0.0000099
-
pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(p-tolyl)prop-2-en-1-amine
0.0000158
-
pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-(benzofuran-3-ylmethyl)-3-(4-bromophenyl)-N-methylprop-2-en-1-amine
0.0000194
-
pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (2E,4E)-N-((1H-indol-7-yl)methyl)-5-([1,1'-biphenyl]-4-yl)-N-methylpenta-2,4-dien-1-amine
0.0000435
-
pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-((1H-indol-7-yl)methyl)-3-(4-(difluoromethyl)phenyl)-N-methylprop-2-en-1-amine
0.0000484
-
pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-((1H-indol-7-yl)methyl)-3-(2-fluoro-4-(trifluoromethyl)-phenyl)-N-methylprop-2-en-1-amine
0.0000648
-
pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-((1H-indol-7-yl)methyl)-3-(4-ethoxyphenyl)-N-methylprop-2-en-1-amine
0.0000731
-
pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-((1H-indol-7-yl)methyl)-3-(2-fluoro-4-methoxyphenyl)-N-methylprop-2-en-1-amine
0.0000741
-
pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-(benzofuran-3-ylmethyl)-3-(3-fluorophenyl)-N-methylprop-2-en-1-amine
0.0000741
-
pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-(benzofuran-3-ylmethyl)-3-(4-fluorophenyl)-N-methylprop-2-en-1-amine
0.0000801
-
pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-4-(3-((benzofuran-3-ylmethyl)(methyl)amino)prop-1-en-1-yl)benzonitrile
0.0000838
-
pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-((1H-indol-7-yl)methyl)-3-(4-bromophenyl)-N-methylprop-2-en-1-amine
0.0000864
-
pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-(benzofuran-3-ylmethyl)-3-(3-chlorophenyl)-N-methylprop-2-en-1-amine
0.0000878
-
pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus methyl (E)-4-(3-(((1H-indol-7-yl)methyl)(methyl)amino)prop-1-en-1-yl)benzoate
0.0000913
-
pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-(benzofuran-3-ylmethyl)-N-methyl-2-en-1-amine
0.0001018
-
pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus N-((1H-indol-7-yl)methyl)-3-([1,1'-biphenyl]-4-yl)-N-methylprop-2-yn-1-amine
0.000118
-
pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (2E)-N-ethyl-N-[(1H-indol-7-yl)methyl]-3-[4-(trifluoromethyl)phenyl]prop-2-en-1-amine
0.0001318
-
pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(naphthalen-2-yl)-prop-2-en-1-amine
0.0001426
-
pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-((1H-indol-7-yl)methyl)-3-(4-chlorophenyl)-N-methylprop-2-en-1-amine
0.000167
-
pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-((1H-indol-7-yl)methyl)-3-(4-methoxyphenyl)-N-methylprop-2-en-1-amine
0.000199
-
pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(p-tolyl)prop-2-en-1-amine
0.0002796
-
pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-((1H-indol-7-yl)methyl)-3-(2,4-dichlorophenyl)-N-methylprop-2-en-1-amine
0.0003598
-
pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-(benzofuran-3-ylmethyl)-3-(2-chlorophenyl)-N-methylprop-2-en-1-amine
0.0003973
-
pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-(benzofuran-3-ylmethyl)-3-cyclopentyl-N-methylprop-2-en-1-amine
0.0007
-
pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-((1H-indol-7-yl)methyl)-3-(4-(tert-butyl)phenyl)-N-methylprop-2-en-1-amine
0.0007847
-
pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-4-(3-(((1H-indol-7-yl)methyl)(methyl)amino)prop-1-en-1-yl)benzonitrile
0.001
-
above, pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (2E)-N-[(1H-indol-7-yl)methyl]-3-(3-methoxyphenyl)-N-methylprop-2-en-1-amine
0.001
-
above, pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (2E)-N-[(1H-indol-7-yl)methyl]-3-[4-(trifluoromethyl)phenyl]prop-2-en-1-amine
0.001
-
above, pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (2E)-N-[(1H-indol-7-yl)methyl]-N-(propan-2-yl)-3-[4-(trifluoromethyl)phenyl]prop-2-en-1-amine
0.001
-
above, pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (2E,4E)-5-([1,1'-biphenyl]-4-yl)-N-(benzofuran-3-ylmethyl)-N-methylpenta-2,4-dien-1-amine
0.001
-
above, pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-3-([1,1'-biphenyl]-4-yl)-N-(benzofuran-3-ylmethyl)-N,2-dimethylprop-2-en-1-amine
0.001
-
above, pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-4-([1,1'-biphenyl]-4-yl)-N-(benzofuran-3-ylmethyl)-N-methylbut-3-en-1-amine
0.001
-
above, pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-((1H-indol-7-yl)methyl)-3-(2-chlorophenyl)-N-methylprop-2-en-1-amine
0.001
-
above, pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-((1H-indol-7-yl)methyl)-3-(2-fluorophenyl)-N-methylprop-2-en-1-amine
0.001
-
above, pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-((1H-indol-7-yl)methyl)-3-(2-methoxyphenyl)-N-methylprop-2-en-1-amine
0.001
-
above, pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-((1H-indol-7-yl)methyl)-3-(3-chlorophenyl)-N-methylprop-2-en-1-amine
0.001
-
above, pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-((1H-indol-7-yl)methyl)-3-(3-fluoro-4-(trifluoromethyl)-phenyl)-N-methylprop-2-en-1-amine
0.001
-
above, pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-((1H-indol-7-yl)methyl)-3-(3-fluorophenyl)-N-methylprop-2-en-1-amine
0.001
-
above, pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-((1H-indol-7-yl)methyl)-3-(4-fluorophenyl)-N-methylprop-2-en-1-amine
0.001
-
above, pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-((1H-indol-7-yl)methyl)-3-(furan-2-yl)-N-methylprop-2-en-1-amine
0.001
-
above, pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-((1H-indol-7-yl)methyl)-3-([1,1'-biphenyl]-4-yl)-N,2-dimethylprop-2-en-1-amine
0.001
-
above, pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-((1H-indol-7-yl)methyl)-3-cyclohexyl-N-methylprop-2-en-1-amine
0.001
-
above, pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-((1H-indol-7-yl)methyl)-3-cyclopentyl-N-methylprop-2-en-1-amine
0.001
-
above, pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-((1H-indol-7-yl)methyl)-4-([1,1'-biphenyl]-4-yl)-N-methylbut-3-en-1-amine
0.001
-
above, pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(2-(trifluoromethyl)phenyl)prop-2-en-1-amine
0.001
-
above, pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(2-nitrophenyl)-prop-2-en-1-amine
0.001
-
above, pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(3-(trifluoromethyl)phenyl)prop-2-en-1-amine
0.001
-
above, pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(3-nitrophenyl)-prop-2-en-1-amine
0.001
-
above, pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(4-nitrophenyl)-prop-2-en-1-amine
0.001
-
above, pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(m-tolyl)prop-2-en-1-amine
0.001
-
above, pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(naphthalen-1-yl)-prop-2-en-1-amine
0.001
-
above, pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(o-tolyl)prop-2-en-1-amine
0.001
-
above, pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(thiophen-2-yl)-prop-2-en-1-amine
0.001
-
above, pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-phenylprop-2-en-1-amine
0.001
-
above, pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-((1H-indol-7-yl)methyl)-N-methylbut-2-en-1-amine
0.001
-
above, pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-((3a,7a-dihydrobenzofuran-3-yl)methyl)-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine
0.001
-
above, pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-((3a,7a-dihydrobenzofuran-3-yl)methyl)-N-ethyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine
0.001
-
above, pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-((3a,7a-dihydrobenzofuran-3-yl)methyl)-N-isopropyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine
0.001
-
above, pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-(benzofuran-3-ylmethyl)-3-(2-fluoro-4-methoxyphenyl)-N-methylprop-2-en-1-amine
0.001
-
above, pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-(benzofuran-3-ylmethyl)-3-(2-fluorophenyl)-N-methylprop-2-en-1-amine
0.001
-
above, pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-(benzofuran-3-ylmethyl)-3-(2-methoxyphenyl)-N-methylprop-2-en-1-amine
0.001
-
above, pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-(benzofuran-3-ylmethyl)-3-(3-fluoro-4-(trifluoromethyl)phenyl)-N-methylprop-2-en-1-amine
0.001
-
above, pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-(benzofuran-3-ylmethyl)-3-(3-fluoro-4-methoxyphenyl)-N-methylprop-2-en-1-amine
0.001
-
above, pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-(benzofuran-3-ylmethyl)-3-(3-methoxyphenyl)-N-methylprop-2-en-1-amine
0.001
-
above, pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-(benzofuran-3-ylmethyl)-3-(4-(tert-butyl)phenyl)-N-methylprop-2-en-1-amine
0.001
-
above, pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-(benzofuran-3-ylmethyl)-3-(4-ethoxyphenyl)-N-methylprop-2-en-1-amine
0.001
-
above, pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-(benzofuran-3-ylmethyl)-3-(furan-2-yl)-N-methylprop-2-en-1-amine
0.001
-
above, pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-(benzofuran-3-ylmethyl)-3-cyclohexyl-N-methylprop-2-en-1-amine
0.001
-
above, pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(2-(trifluoromethyl)phenyl)prop-2-en-1-amine
0.001
-
above, pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(2-nitrophenyl)-prop-2-en-1-amine
0.001
-
above, pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(3-(trifluoromethyl)phenyl)prop-2-en-1-amine
0.001
-
above, pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(3-nitrophenyl)-prop-2-en-1-amine
0.001
-
above, pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(m-tolyl)prop-2-en-1-amine
0.001
-
above, pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(naphthalen-1-yl)prop-2-en-1-amine
0.001
-
above, pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(o-tolyl)prop-2-en-1-amine
0.001
-
above, pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(thiophen-2-yl)-prop-2-en-1-amine
0.001
-
above, pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-phenylprop-2-en-1-amine
0.001
-
above, pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus 3-([1,1'-biphenyl]-4-yl)-N-(benzofuran-3-ylmethyl)-N-methylprop-2-yn-1-amine
0.001
-
above, pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus 3-([1,1'-biphenyl]-4-yl)-N-(benzofuran-3-ylmethyl)-N-methylpropan-1-amine
0.001
-
above, pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus (E)-N-((1H-indol-7-yl)methyl)-3-(3-fluoro-4-methoxyphenyl)-N-methylprop-2-en-1-amine
0.001
-
above, pH 7.5, 37°C, recombinant His-tagged enzyme Staphylococcus aureus N-((1H-indol-7-yl)methyl)-3-([1,1'-biphenyl]-4-yl)-N-methylpropan-1-amine