Application | Comment | Organism |
---|---|---|
drug development | the enzyme CrtN is an attractive and druggable target for fighting pigmented Staphylococcus aureus infections | Staphylococcus aureus |
medicine | the enzyme CrtN is an attractive and druggable target for fighting pigmented Staphylococcus aureus infections | Staphylococcus aureus |
Cloned (Comment) | Organism |
---|---|
recombinant expression of His-tagged enzyme | Staphylococcus aureus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2E)-N-ethyl-N-[(1H-indol-7-yl)methyl]-3-[4-(trifluoromethyl)phenyl]prop-2-en-1-amine | - |
Staphylococcus aureus | |
(2E)-N-[(1H-indol-7-yl)methyl]-3-(3-methoxyphenyl)-N-methylprop-2-en-1-amine | - |
Staphylococcus aureus | |
(2E)-N-[(1H-indol-7-yl)methyl]-3-[4-(trifluoromethyl)phenyl]prop-2-en-1-amine | - |
Staphylococcus aureus | |
(2E)-N-[(1H-indol-7-yl)methyl]-N-(propan-2-yl)-3-[4-(trifluoromethyl)phenyl]prop-2-en-1-amine | - |
Staphylococcus aureus | |
(2E,4E)-5-([1,1'-biphenyl]-4-yl)-N-(benzofuran-3-ylmethyl)-N-methylpenta-2,4-dien-1-amine | - |
Staphylococcus aureus | |
(2E,4E)-N-((1H-indol-7-yl)methyl)-5-([1,1'-biphenyl]-4-yl)-N-methylpenta-2,4-dien-1-amine | - |
Staphylococcus aureus | |
(E)-3-([1,1'-biphenyl]-4-yl)-N-(benzofuran-3-ylmethyl)-N,2-dimethylprop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-3-([1,1'-biphenyl]-4-yl)-N-(benzofuran-3-ylmethyl)-N-methylprop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-4-(3-(((1H-indol-7-yl)methyl)(methyl)amino)prop-1-en-1-yl)benzonitrile | - |
Staphylococcus aureus | |
(E)-4-(3-((benzofuran-3-ylmethyl)(methyl)amino)prop-1-en-1-yl)benzonitrile | - |
Staphylococcus aureus | |
(E)-4-([1,1'-biphenyl]-4-yl)-N-(benzofuran-3-ylmethyl)-N-methylbut-3-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-((1H-indol-2-yl)methyl)-N-methyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-((1H-indol-3-yl)methyl)-N-methyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-((1H-indol-4-yl)methyl)-N-methyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-((1H-indol-5-yl)methyl)-N-methyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-((1H-indol-6-yl)methyl)-N-methyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-((1H-indol-7-yl)methyl)-3-(2,4-dichlorophenyl)-N-methylprop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-((1H-indol-7-yl)methyl)-3-(2-chlorophenyl)-N-methylprop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-((1H-indol-7-yl)methyl)-3-(2-fluoro-4-(trifluoromethyl)-phenyl)-N-methylprop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-((1H-indol-7-yl)methyl)-3-(2-fluoro-4-methoxyphenyl)-N-methylprop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-((1H-indol-7-yl)methyl)-3-(2-fluorophenyl)-N-methylprop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-((1H-indol-7-yl)methyl)-3-(2-methoxyphenyl)-N-methylprop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-((1H-indol-7-yl)methyl)-3-(3-chlorophenyl)-N-methylprop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-((1H-indol-7-yl)methyl)-3-(3-fluoro-4-(trifluoromethyl)-phenyl)-N-methylprop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-((1H-indol-7-yl)methyl)-3-(3-fluoro-4-methoxyphenyl)-N-methylprop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-((1H-indol-7-yl)methyl)-3-(3-fluorophenyl)-N-methylprop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-((1H-indol-7-yl)methyl)-3-(4-(difluoromethyl)phenyl)-N-methylprop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-((1H-indol-7-yl)methyl)-3-(4-(tert-butyl)phenyl)-N-methylprop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-((1H-indol-7-yl)methyl)-3-(4-bromophenyl)-N-methylprop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-((1H-indol-7-yl)methyl)-3-(4-chlorophenyl)-N-methylprop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-((1H-indol-7-yl)methyl)-3-(4-ethoxyphenyl)-N-methylprop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-((1H-indol-7-yl)methyl)-3-(4-fluorophenyl)-N-methylprop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-((1H-indol-7-yl)methyl)-3-(4-methoxyphenyl)-N-methylprop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-((1H-indol-7-yl)methyl)-3-(furan-2-yl)-N-methylprop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-((1H-indol-7-yl)methyl)-3-([1,1'-biphenyl]-4-yl)-N,2-dimethylprop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-((1H-indol-7-yl)methyl)-3-([1,1'-biphenyl]-4-yl)-N-methylprop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-((1H-indol-7-yl)methyl)-3-cyclohexyl-N-methylprop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-((1H-indol-7-yl)methyl)-3-cyclopentyl-N-methylprop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-((1H-indol-7-yl)methyl)-4-([1,1'-biphenyl]-4-yl)-N-methylbut-3-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(2-(trifluoromethyl)phenyl)prop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(2-nitrophenyl)-prop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(3-(trifluoromethyl)phenyl)prop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(3-nitrophenyl)-prop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(4-nitrophenyl)-prop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(m-tolyl)prop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(naphthalen-1-yl)-prop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(naphthalen-2-yl)-prop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(o-tolyl)prop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(p-tolyl)prop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(thiophen-2-yl)-prop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-phenylprop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-((1H-indol-7-yl)methyl)-N-methylbut-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-((3a,7a-dihydrobenzofuran-3-yl)methyl)-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-((3a,7a-dihydrobenzofuran-3-yl)methyl)-N-ethyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-((3a,7a-dihydrobenzofuran-3-yl)methyl)-N-isopropyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-(benzofuran-2-ylmethyl)-N-methyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-(benzofuran-3-ylmethyl)-3-(2,4-dichlorophenyl)-Nmethylprop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-(benzofuran-3-ylmethyl)-3-(2-chlorophenyl)-N-methylprop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-(benzofuran-3-ylmethyl)-3-(2-fluoro-4-(trifluoromethyl)phenyl)-N-methylprop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-(benzofuran-3-ylmethyl)-3-(2-fluoro-4-methoxyphenyl)-N-methylprop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-(benzofuran-3-ylmethyl)-3-(2-fluorophenyl)-N-methylprop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-(benzofuran-3-ylmethyl)-3-(2-methoxyphenyl)-N-methylprop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-(benzofuran-3-ylmethyl)-3-(3-chlorophenyl)-N-methylprop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-(benzofuran-3-ylmethyl)-3-(3-fluoro-4-(trifluoromethyl)phenyl)-N-methylprop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-(benzofuran-3-ylmethyl)-3-(3-fluoro-4-methoxyphenyl)-N-methylprop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-(benzofuran-3-ylmethyl)-3-(3-fluorophenyl)-N-methylprop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-(benzofuran-3-ylmethyl)-3-(3-methoxyphenyl)-N-methylprop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-(benzofuran-3-ylmethyl)-3-(4-(difluoromethyl)phenyl)-N-methylprop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-(benzofuran-3-ylmethyl)-3-(4-(tert-butyl)phenyl)-N-methylprop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-(benzofuran-3-ylmethyl)-3-(4-bromophenyl)-N-methylprop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-(benzofuran-3-ylmethyl)-3-(4-chlorophenyl)-N-methylprop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-(benzofuran-3-ylmethyl)-3-(4-ethoxyphenyl)-N-methylprop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-(benzofuran-3-ylmethyl)-3-(4-fluorophenyl)-N-methylprop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-(benzofuran-3-ylmethyl)-3-(furan-2-yl)-N-methylprop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-(benzofuran-3-ylmethyl)-3-cyclohexyl-N-methylprop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-(benzofuran-3-ylmethyl)-3-cyclohexyl-N-methyprop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-(benzofuran-3-ylmethyl)-3-cyclopentyl-N-methylprop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-(benzofuran-3-ylmethyl)-3-cyclopentyl-N-methyprop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-(benzofuran-3-ylmethyl)-N-methyl-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(2-(trifluoromethyl)phenyl)prop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(2-nitrophenyl)-prop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(3-(trifluoromethyl)phenyl)prop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(3-nitrophenyl)-prop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(4-nitrophenyl)-prop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(m-tolyl)prop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(naphthalen-1-yl)prop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(naphthalen-2-yl)prop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(o-tolyl)prop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(p-tolyl)prop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(thiophen-2-yl)-prop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-phenylprop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-(benzo[b]thiophen-2-ylmethyl)-N-methyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine | - |
Staphylococcus aureus | |
(E)-N-(benzo[b]thiophen-3-ylmethyl)-N-methyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine | - |
Staphylococcus aureus | |
3-([1,1'-biphenyl]-4-yl)-N-(benzofuran-3-ylmethyl)-N-methylprop-2-yn-1-amine | - |
Staphylococcus aureus | |
3-([1,1'-biphenyl]-4-yl)-N-(benzofuran-3-ylmethyl)-N-methylpropan-1-amine | - |
Staphylococcus aureus | |
linezolid | - |
Staphylococcus aureus | |
methyl (E)-4-(3-(((1H-indol-7-yl)methyl)(methyl)amino)prop-1-en-1-yl)benzoate | - |
Staphylococcus aureus | |
methyl (E)-4-(3-((benzofuran-3-ylmethyl)(methyl)amino)-prop-1-en-1-yl)benzoate | - |
Staphylococcus aureus | |
methyl(E)-4-(3-((benzofuran-3-ylmethyl)(methyl)amino)-prop-1-en-1-yl)benzoate | - |
Staphylococcus aureus | |
additional information | synthesis of a series of CrtN inhibitors with other scaffolds, method overview. The compounds show excellent activity against different MRSA in in vitro and in vivo at a lower dosage but also overcome the disadvantages of hERG inhibition. Linezolid and vancomycin, the last-resort antimicrobial agents, are introduced as positive control drugs into a murine model of Staphylococcus aureus abscess formation to evaluate the effectiveness of the analogues. Diapophytoene desaturase inhibitors for the treatment of methicillin-, vancomycin- and linezolid-resistant Staphylococcus aureus infections, cytotoxicity analysis using Hep-G2 and HEK-293T cells and BALB-C mice, in vitro pigment inhibitory activities, in vivo cytotoxicity IC50 values and pigment inhibition activity IC50 values, overview | Staphylococcus aureus | |
N-((1H-indol-7-yl)methyl)-3-([1,1'-biphenyl]-4-yl)-N-methylprop-2-yn-1-amine | - |
Staphylococcus aureus | |
N-((1H-indol-7-yl)methyl)-3-([1,1'-biphenyl]-4-yl)-N-methylpropan-1-amine | - |
Staphylococcus aureus | |
Vancomycin | - |
Staphylococcus aureus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
15-cis-4,4'-diapophytoene + 4 FAD | Staphylococcus aureus | overall reaction | all-trans-4,4'-diapolycopene + 4 FADH2 | - |
? | |
15-cis-4,4'-diapophytoene + 4 FAD | Staphylococcus aureus Newman | overall reaction | all-trans-4,4'-diapolycopene + 4 FADH2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Staphylococcus aureus | O07855 | - |
- |
Staphylococcus aureus Newman | O07855 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
15-cis-4,4'-diapophytoene + 4 FAD | overall reaction | Staphylococcus aureus | all-trans-4,4'-diapolycopene + 4 FADH2 | - |
? | |
15-cis-4,4'-diapophytoene + 4 FAD | overall reaction | Staphylococcus aureus Newman | all-trans-4,4'-diapolycopene + 4 FADH2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CrtN | - |
Staphylococcus aureus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at, recombinant enzyme | Staphylococcus aureus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at, recombinant enzyme | Staphylococcus aureus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Staphylococcus aureus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000002 | - |
pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-3-([1,1'-biphenyl]-4-yl)-N-(benzofuran-3-ylmethyl)-N-methylprop-2-en-1-amine | |
0.0000025 | - |
pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-(benzofuran-3-ylmethyl)-3-(4-bromophenyl)-N-methylprop-2-en-1-amine | |
0.0000033 | - |
pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-((1H-indol-7-yl)methyl)-3-([1,1'-biphenyl]-4-yl)-N-methylprop-2-en-1-amine | |
0.0000049 | - |
pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-(benzofuran-3-ylmethyl)-3-(4-chlorophenyl)-N-methylprop-2-en-1-amine | |
0.0000062 | - |
pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-(benzofuran-3-ylmethyl)-3-(2,4-dichlorophenyl)-Nmethylprop-2-en-1-amine | |
0.0000064 | - |
pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-(benzofuran-3-ylmethyl)-3-(4-(difluoromethyl)phenyl)-N-methylprop-2-en-1-amine | |
0.0000064 | - |
pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(naphthalen-2-yl)prop-2-en-1-amine | |
0.0000092 | - |
pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-(benzofuran-3-ylmethyl)-3-(2-fluoro-4-(trifluoromethyl)phenyl)-N-methylprop-2-en-1-amine | |
0.0000095 | - |
pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(4-nitrophenyl)-prop-2-en-1-amine | |
0.0000095 | - |
pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | methyl (E)-4-(3-((benzofuran-3-ylmethyl)(methyl)amino)-prop-1-en-1-yl)benzoate | |
0.0000099 | - |
pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(p-tolyl)prop-2-en-1-amine | |
0.0000158 | - |
pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-(benzofuran-3-ylmethyl)-3-(4-bromophenyl)-N-methylprop-2-en-1-amine | |
0.0000194 | - |
pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (2E,4E)-N-((1H-indol-7-yl)methyl)-5-([1,1'-biphenyl]-4-yl)-N-methylpenta-2,4-dien-1-amine | |
0.0000435 | - |
pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-((1H-indol-7-yl)methyl)-3-(4-(difluoromethyl)phenyl)-N-methylprop-2-en-1-amine | |
0.0000484 | - |
pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-((1H-indol-7-yl)methyl)-3-(2-fluoro-4-(trifluoromethyl)-phenyl)-N-methylprop-2-en-1-amine | |
0.0000648 | - |
pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-((1H-indol-7-yl)methyl)-3-(4-ethoxyphenyl)-N-methylprop-2-en-1-amine | |
0.0000731 | - |
pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-((1H-indol-7-yl)methyl)-3-(2-fluoro-4-methoxyphenyl)-N-methylprop-2-en-1-amine | |
0.0000741 | - |
pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-(benzofuran-3-ylmethyl)-3-(3-fluorophenyl)-N-methylprop-2-en-1-amine | |
0.0000741 | - |
pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-(benzofuran-3-ylmethyl)-3-(4-fluorophenyl)-N-methylprop-2-en-1-amine | |
0.0000801 | - |
pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-4-(3-((benzofuran-3-ylmethyl)(methyl)amino)prop-1-en-1-yl)benzonitrile | |
0.0000838 | - |
pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-((1H-indol-7-yl)methyl)-3-(4-bromophenyl)-N-methylprop-2-en-1-amine | |
0.0000864 | - |
pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-(benzofuran-3-ylmethyl)-3-(3-chlorophenyl)-N-methylprop-2-en-1-amine | |
0.0000878 | - |
pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | methyl (E)-4-(3-(((1H-indol-7-yl)methyl)(methyl)amino)prop-1-en-1-yl)benzoate | |
0.0000913 | - |
pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-(benzofuran-3-ylmethyl)-N-methyl-2-en-1-amine | |
0.0001018 | - |
pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | N-((1H-indol-7-yl)methyl)-3-([1,1'-biphenyl]-4-yl)-N-methylprop-2-yn-1-amine | |
0.000118 | - |
pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (2E)-N-ethyl-N-[(1H-indol-7-yl)methyl]-3-[4-(trifluoromethyl)phenyl]prop-2-en-1-amine | |
0.0001318 | - |
pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(naphthalen-2-yl)-prop-2-en-1-amine | |
0.0001426 | - |
pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-((1H-indol-7-yl)methyl)-3-(4-chlorophenyl)-N-methylprop-2-en-1-amine | |
0.000167 | - |
pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-((1H-indol-7-yl)methyl)-3-(4-methoxyphenyl)-N-methylprop-2-en-1-amine | |
0.000199 | - |
pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(p-tolyl)prop-2-en-1-amine | |
0.0002796 | - |
pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-((1H-indol-7-yl)methyl)-3-(2,4-dichlorophenyl)-N-methylprop-2-en-1-amine | |
0.0003598 | - |
pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-(benzofuran-3-ylmethyl)-3-(2-chlorophenyl)-N-methylprop-2-en-1-amine | |
0.0003973 | - |
pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-(benzofuran-3-ylmethyl)-3-cyclopentyl-N-methylprop-2-en-1-amine | |
0.0007 | - |
pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-((1H-indol-7-yl)methyl)-3-(4-(tert-butyl)phenyl)-N-methylprop-2-en-1-amine | |
0.0007847 | - |
pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-4-(3-(((1H-indol-7-yl)methyl)(methyl)amino)prop-1-en-1-yl)benzonitrile | |
0.001 | - |
above, pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (2E)-N-[(1H-indol-7-yl)methyl]-3-(3-methoxyphenyl)-N-methylprop-2-en-1-amine | |
0.001 | - |
above, pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (2E)-N-[(1H-indol-7-yl)methyl]-3-[4-(trifluoromethyl)phenyl]prop-2-en-1-amine | |
0.001 | - |
above, pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (2E)-N-[(1H-indol-7-yl)methyl]-N-(propan-2-yl)-3-[4-(trifluoromethyl)phenyl]prop-2-en-1-amine | |
0.001 | - |
above, pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (2E,4E)-5-([1,1'-biphenyl]-4-yl)-N-(benzofuran-3-ylmethyl)-N-methylpenta-2,4-dien-1-amine | |
0.001 | - |
above, pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-3-([1,1'-biphenyl]-4-yl)-N-(benzofuran-3-ylmethyl)-N,2-dimethylprop-2-en-1-amine | |
0.001 | - |
above, pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-4-([1,1'-biphenyl]-4-yl)-N-(benzofuran-3-ylmethyl)-N-methylbut-3-en-1-amine | |
0.001 | - |
above, pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-((1H-indol-7-yl)methyl)-3-(2-chlorophenyl)-N-methylprop-2-en-1-amine | |
0.001 | - |
above, pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-((1H-indol-7-yl)methyl)-3-(2-fluorophenyl)-N-methylprop-2-en-1-amine | |
0.001 | - |
above, pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-((1H-indol-7-yl)methyl)-3-(2-methoxyphenyl)-N-methylprop-2-en-1-amine | |
0.001 | - |
above, pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-((1H-indol-7-yl)methyl)-3-(3-chlorophenyl)-N-methylprop-2-en-1-amine | |
0.001 | - |
above, pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-((1H-indol-7-yl)methyl)-3-(3-fluoro-4-(trifluoromethyl)-phenyl)-N-methylprop-2-en-1-amine | |
0.001 | - |
above, pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-((1H-indol-7-yl)methyl)-3-(3-fluorophenyl)-N-methylprop-2-en-1-amine | |
0.001 | - |
above, pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-((1H-indol-7-yl)methyl)-3-(4-fluorophenyl)-N-methylprop-2-en-1-amine | |
0.001 | - |
above, pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-((1H-indol-7-yl)methyl)-3-(furan-2-yl)-N-methylprop-2-en-1-amine | |
0.001 | - |
above, pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-((1H-indol-7-yl)methyl)-3-([1,1'-biphenyl]-4-yl)-N,2-dimethylprop-2-en-1-amine | |
0.001 | - |
above, pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-((1H-indol-7-yl)methyl)-3-cyclohexyl-N-methylprop-2-en-1-amine | |
0.001 | - |
above, pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-((1H-indol-7-yl)methyl)-3-cyclopentyl-N-methylprop-2-en-1-amine | |
0.001 | - |
above, pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-((1H-indol-7-yl)methyl)-4-([1,1'-biphenyl]-4-yl)-N-methylbut-3-en-1-amine | |
0.001 | - |
above, pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(2-(trifluoromethyl)phenyl)prop-2-en-1-amine | |
0.001 | - |
above, pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(2-nitrophenyl)-prop-2-en-1-amine | |
0.001 | - |
above, pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(3-(trifluoromethyl)phenyl)prop-2-en-1-amine | |
0.001 | - |
above, pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(3-nitrophenyl)-prop-2-en-1-amine | |
0.001 | - |
above, pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(4-nitrophenyl)-prop-2-en-1-amine | |
0.001 | - |
above, pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(m-tolyl)prop-2-en-1-amine | |
0.001 | - |
above, pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(naphthalen-1-yl)-prop-2-en-1-amine | |
0.001 | - |
above, pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(o-tolyl)prop-2-en-1-amine | |
0.001 | - |
above, pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-(thiophen-2-yl)-prop-2-en-1-amine | |
0.001 | - |
above, pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-((1H-indol-7-yl)methyl)-N-methyl-3-phenylprop-2-en-1-amine | |
0.001 | - |
above, pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-((1H-indol-7-yl)methyl)-N-methylbut-2-en-1-amine | |
0.001 | - |
above, pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-((3a,7a-dihydrobenzofuran-3-yl)methyl)-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine | |
0.001 | - |
above, pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-((3a,7a-dihydrobenzofuran-3-yl)methyl)-N-ethyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine | |
0.001 | - |
above, pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-((3a,7a-dihydrobenzofuran-3-yl)methyl)-N-isopropyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-amine | |
0.001 | - |
above, pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-(benzofuran-3-ylmethyl)-3-(2-fluoro-4-methoxyphenyl)-N-methylprop-2-en-1-amine | |
0.001 | - |
above, pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-(benzofuran-3-ylmethyl)-3-(2-fluorophenyl)-N-methylprop-2-en-1-amine | |
0.001 | - |
above, pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-(benzofuran-3-ylmethyl)-3-(2-methoxyphenyl)-N-methylprop-2-en-1-amine | |
0.001 | - |
above, pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-(benzofuran-3-ylmethyl)-3-(3-fluoro-4-(trifluoromethyl)phenyl)-N-methylprop-2-en-1-amine | |
0.001 | - |
above, pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-(benzofuran-3-ylmethyl)-3-(3-fluoro-4-methoxyphenyl)-N-methylprop-2-en-1-amine | |
0.001 | - |
above, pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-(benzofuran-3-ylmethyl)-3-(3-methoxyphenyl)-N-methylprop-2-en-1-amine | |
0.001 | - |
above, pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-(benzofuran-3-ylmethyl)-3-(4-(tert-butyl)phenyl)-N-methylprop-2-en-1-amine | |
0.001 | - |
above, pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-(benzofuran-3-ylmethyl)-3-(4-ethoxyphenyl)-N-methylprop-2-en-1-amine | |
0.001 | - |
above, pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-(benzofuran-3-ylmethyl)-3-(furan-2-yl)-N-methylprop-2-en-1-amine | |
0.001 | - |
above, pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-(benzofuran-3-ylmethyl)-3-cyclohexyl-N-methylprop-2-en-1-amine | |
0.001 | - |
above, pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(2-(trifluoromethyl)phenyl)prop-2-en-1-amine | |
0.001 | - |
above, pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(2-nitrophenyl)-prop-2-en-1-amine | |
0.001 | - |
above, pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(3-(trifluoromethyl)phenyl)prop-2-en-1-amine | |
0.001 | - |
above, pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(3-nitrophenyl)-prop-2-en-1-amine | |
0.001 | - |
above, pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(m-tolyl)prop-2-en-1-amine | |
0.001 | - |
above, pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(naphthalen-1-yl)prop-2-en-1-amine | |
0.001 | - |
above, pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(o-tolyl)prop-2-en-1-amine | |
0.001 | - |
above, pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-(thiophen-2-yl)-prop-2-en-1-amine | |
0.001 | - |
above, pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-(benzofuran-3-ylmethyl)-N-methyl-3-phenylprop-2-en-1-amine | |
0.001 | - |
above, pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | 3-([1,1'-biphenyl]-4-yl)-N-(benzofuran-3-ylmethyl)-N-methylprop-2-yn-1-amine | |
0.001 | - |
above, pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | 3-([1,1'-biphenyl]-4-yl)-N-(benzofuran-3-ylmethyl)-N-methylpropan-1-amine | |
0.001 | - |
above, pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | (E)-N-((1H-indol-7-yl)methyl)-3-(3-fluoro-4-methoxyphenyl)-N-methylprop-2-en-1-amine | |
0.001 | - |
above, pH 7.5, 37°C, recombinant His-tagged enzyme | Staphylococcus aureus | N-((1H-indol-7-yl)methyl)-3-([1,1'-biphenyl]-4-yl)-N-methylpropan-1-amine |