Literature summary for 1.3.8.2 extracted from

Chen, F.; Di, H.; Wang, Y.; Cao, Q.; Xu, B.; Zhang, X.; Yang, N.; Liu, G.; Yang, C.G.; Xu, Y.; Jiang, H.; Lian, F.; Zhang, N.; Li, J.; Lan, L.
Small-molecule targeting of a diapophytoene desaturase inhibits S. aureus virulence (2016), Nat. Chem. Biol., 12, 174-179 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
naftifine	blocks biosynthesis of carotenoid pigment at nanomolar concentrations by competitive inhibition of diapophytoene desaturase CrtN. Naftifine attenuates the virulence of strain Newman and of a variety of clinical Staphylocuus aureus isolates, in mouse infection models	Staphylococcus aureus

Organism

Organism	UniProt	Comment	Textmining
Staphylococcus aureus	O07855	-	-
Staphylococcus aureus Newman	O07855	-	-

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Release 2023.1 (January 2023)