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Literature summary for 1.3.7.6 extracted from

  • Alvey, R.M.; Biswas, A.; Schluchter, W.M.; Bryant, D.A.
    Effects of modified phycobilin biosynthesis in the cyanobacterium Synechococcus sp. strain PCC 7002 (2011), J. Bacteriol., 193, 1663-1671.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.3.7.6

Cloned(Commentary)

Cloned (Comment) Organism
gene pebAB, overexpression in Synechococcus sp. strain PCC 7002, from endogenous plasmid pAQ1 under the control of the Synechocystis sp. strain PCC 6803 cpcBA promoter, leads to overproduction of phytochromobilin. Colonies of Synechococcus sp. strain PCC 7002 transformed with the pebAB overexpression cassette mostly exhibit a reddish-brown phenotype Synechococcus sp.

Protein Variants

Protein Variants Comment Organism
additional information because PcyA, EC 1.3.7.5, and PebA utilize the same substrate, biliverdin IXalpha, severe overexpression of pebA can limit the availability of phycocyanobilin, which appears to be required for viability when cells are grown in continuous light, phenotype, overview Synechococcus sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
biliverdin IXalpha + 2 reduced ferredoxin Synechococcus sp.
-
 (3Z)-phycoerythrobilin + 2 oxidized ferredoxin
-
 ?
biliverdin IXalpha + 2 reduced ferredoxin Synechococcus sp. PCC 7335
-
 (3Z)-phycoerythrobilin + 2 oxidized ferredoxin
-
 ?

Organism

Organism UniProt Comment Textmining
Synechococcus sp.
-
 gene pebAB
-
Synechococcus sp. PCC 7335
-
 gene pebAB
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
biliverdin IXalpha + 2 reduced ferredoxin
-
 Synechococcus sp. (3Z)-phycoerythrobilin + 2 oxidized ferredoxin
-
 ?
biliverdin IXalpha + 2 reduced ferredoxin (3Z)-phycoerythrobilin is synthesized from biliverdin IXalpha by the sequential actions of two reductases, PebA and PebB Synechococcus sp. (3Z)-phycoerythrobilin + 2 oxidized ferredoxin
-
 ?
biliverdin IXalpha + 2 reduced ferredoxin
-
 Synechococcus sp. PCC 7335 (3Z)-phycoerythrobilin + 2 oxidized ferredoxin
-
 ?
biliverdin IXalpha + 2 reduced ferredoxin (3Z)-phycoerythrobilin is synthesized from biliverdin IXalpha by the sequential actions of two reductases, PebA and PebB Synechococcus sp. PCC 7335 (3Z)-phycoerythrobilin + 2 oxidized ferredoxin
-
 ?

Synonyms

Synonyms Comment Organism
PebA
-
 Synechococcus sp.
PebB
-
 Synechococcus sp.

Cofactor

Cofactor Comment Organism Structure
Ferredoxin
-
 Synechococcus sp.

General Information

General Information Comment Organism
evolution synthesis of linear tetrapyrrole chromophores in cyanobacteria, algae, and plants, ooverview Synechococcus sp.