BRENDA - Reference to 1.3.7.5; Id = 725252

additional information

insertional inactivation of pcyA is not possible in wild-type Synechococcus sp. strain PCC 7002 due to lethality of the mutant, but in a variant heterologously expressing HY2 from Arabidopsis thaliana encoding a phytochromobilin:ferredoxin oxidoreductase

Synechococcus sp.

biliverdin Ixalpha + reduced ferredoxin

Synechococcus sp.

-

(3Z)-phycocyanobilin + oxidized ferredoxin

-

?

biliverdin Ixalpha + reduced ferredoxin

Synechococcus sp. PCC 7335

-

(3Z)-phycocyanobilin + oxidized ferredoxin

-

?

Synechococcus sp.

-

biliverdin Ixalpha + reduced ferredoxin

-

725252

Synechococcus sp.

(3Z)-phycocyanobilin + oxidized ferredoxin

-

?

biliverdin Ixalpha + reduced ferredoxin

phycocyanobilin:ferredoxin oxidoreductase uses four electrons from reduced ferredoxin to synthesize phycocyanobilin by regiospecific reduction of the exo vinyl group of ring D and the endo vinyl group of ring A of biliverdin IXalpha

725252

Synechococcus sp.

(3Z)-phycocyanobilin + oxidized ferredoxin

-

?

biliverdin Ixalpha + reduced ferredoxin

-

725252

Synechococcus sp. PCC 7335

(3Z)-phycocyanobilin + oxidized ferredoxin

-

?

biliverdin Ixalpha + reduced ferredoxin

phycocyanobilin:ferredoxin oxidoreductase uses four electrons from reduced ferredoxin to synthesize phycocyanobilin by regiospecific reduction of the exo vinyl group of ring D and the endo vinyl group of ring A of biliverdin IXalpha

725252

Synechococcus sp. PCC 7335

(3Z)-phycocyanobilin + oxidized ferredoxin

-

?

PCB:ferredoxin oxidoreductase

-

Synechococcus sp.

PcyA

-

Synechococcus sp.

phycocyanobilin synthase

-

Synechococcus sp.

Ferredoxin

-

Synechococcus sp.

Ferredoxin

-

Synechococcus sp.

additional information

insertional inactivation of pcyA is not possible in wild-type Synechococcus sp. strain PCC 7002 due to lethality of the mutant, but in a variant heterologously expressing HY2 from Arabidopsis thaliana encoding a phytochromobilin:ferredoxin oxidoreductase

Synechococcus sp.

biliverdin Ixalpha + reduced ferredoxin

Synechococcus sp.

-

(3Z)-phycocyanobilin + oxidized ferredoxin

-

?

biliverdin Ixalpha + reduced ferredoxin

Synechococcus sp. PCC 7335

-

(3Z)-phycocyanobilin + oxidized ferredoxin

-

?

biliverdin Ixalpha + reduced ferredoxin

-

725252

Synechococcus sp.

(3Z)-phycocyanobilin + oxidized ferredoxin

-

?

biliverdin Ixalpha + reduced ferredoxin

phycocyanobilin:ferredoxin oxidoreductase uses four electrons from reduced ferredoxin to synthesize phycocyanobilin by regiospecific reduction of the exo vinyl group of ring D and the endo vinyl group of ring A of biliverdin IXalpha

725252

Synechococcus sp.

(3Z)-phycocyanobilin + oxidized ferredoxin

-

?

biliverdin Ixalpha + reduced ferredoxin

-

725252

Synechococcus sp. PCC 7335

(3Z)-phycocyanobilin + oxidized ferredoxin

-

?

biliverdin Ixalpha + reduced ferredoxin

phycocyanobilin:ferredoxin oxidoreductase uses four electrons from reduced ferredoxin to synthesize phycocyanobilin by regiospecific reduction of the exo vinyl group of ring D and the endo vinyl group of ring A of biliverdin IXalpha

725252

Synechococcus sp. PCC 7335

(3Z)-phycocyanobilin + oxidized ferredoxin

-

?

evolution

synthesis of linear tetrapyrrole chromophores in cyanobacteria, algae, and plants, ooverview

Synechococcus sp.

malfunction

because PcyA and PebA, EC 1.3.7.6/1.3.7.3, utilize the same substrate, biliverdin IXalpha, severe overexpression of pebA can limit the availability of phycocyanobilin, which appears to be required for viability when cells are grown in continuous light

Synechococcus sp.

physiological function

the pcyA gene of Synechococcus sp. strain PCC 7002 is essential

Synechococcus sp.

evolution

synthesis of linear tetrapyrrole chromophores in cyanobacteria, algae, and plants, ooverview

Synechococcus sp.

malfunction

because PcyA and PebA, EC 1.3.7.6/1.3.7.3, utilize the same substrate, biliverdin IXalpha, severe overexpression of pebA can limit the availability of phycocyanobilin, which appears to be required for viability when cells are grown in continuous light

Synechococcus sp.

physiological function

the pcyA gene of Synechococcus sp. strain PCC 7002 is essential

Synechococcus sp.

742318

Ceron-Carrasco

-

First computational step towa ...

Synechocystis sp. PCC 6803

Comput. Theoret. Chem.

1077

58-64

2016

-

1

-

1

-

1

-

742524

Hagiwara

Atomic-resolution structure o ...

Synechocystis sp. PCC 6803

FEBS Lett.

590

3425-3434

2016

-

1

-

2

-

1

-

1

-

1

-

724131

Kabasakal

His74 conservation in the bili ...

Synechocystis sp.

Arch. Biochem. Biophys.

537

233-242

2013

-

1

3

-

1

-

1

-

1

-

2

1

2

1

-

1

-

1

-

1

3

-

1

-

1

-

2

1

-

1

-

3

-

724317

Alvey

Attachment of noncognate chrom ...

Synechococcus sp., Synechococcus sp. 7002

Biochemistry

50

4890-4902

2011

-

1

-

2

-

12

-

2

-

2

-

1

-

1

-

2

-

2

-

1

-

725252

Alvey

Effects of modified phycobilin ...

Synechococcus sp.

J. Bacteriol.

193

1663-1671

2011

-

1

-

2

-

5

-

4

-

3

-

1

-

1

-

1

-

2

-

4

-

3

-

711117

Wada

One residue substitution in Pc ...

Synechocystis sp.

Biochem. Biophys. Res. Commun.

402

373-377

2010

-

1

-

1

-

3

-

2

-

1

-

1

-

1

-

1

-

2

-

712411

Hagiwara

Structural insights into vinyl ...

Synechocystis sp.

J. Biol. Chem.

285

1000-1007

2010

-

1

-

1

-

5

-

3

-

1

-

1

-

1

-

1

-

1

-

3

-

1

-

1

-

724287

Shang

Biliverdin amides reveal roles ...

Anabaena sp., Anabaena sp. PCC 7120

Biochemistry

49

6070-6082

2010

-

1

-

2

-

22

-

1

-

13

-

2

-

2

-

1

-

1

-

2

-

1

-

13

-

2

-

2

-

724288

Kohler

Structural basis for hydration ...

Synechocystis sp.

Biochemistry

49

6206-6218

2010

-

1

2

-

1

-

3

-

1

-

1

-

1

-

1

2

-

1

-

1

-

1

-

2

-

696870

Zhang

Biosynthesis of fluorescent al ...

Synechocystis sp.

Biotechnol. Appl. Biochem.

52

135-140

2009

-

1

-

1

-

1

-

1

-

1

-

698489

Stoll

Structure of the biliverdin ra ...

Synechocystis sp., Nostoc sp. PCC 7120 = FACHB-418

J. Am. Chem. Soc.

131

1986-1995

2009

-

2

3

-

12

-

2

3

-

712008

Okada

HO1 and PcyA proteins involved ...

Thermosynechococcus elongatus

FEBS Lett.

583

1251-1256

2009

-

1

-

1

-

1

-

1

-

1

2

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

685125

Tu

Insight into the radical mecha ...

Nostoc sp. PCC 7120 = FACHB-418

Biochemistry

46

1484-1494

2007

-

1

5

-

8

-

1

-

1

-

2

-

1

5

-

1

-

1

-

673636

Mukougawa

Metabolic engineering to produ ...

Synechococcus sp., Synechococcus sp. W8020

FEBS Lett.

580

1333-1338

2006

-

1

-

2

-

2

-

1

-

1

-

2

-

673657

Hagiwara

Induced-fitting and electrosta ...

Synechocystis sp.

FEBS Lett.

580

3823-3828

2006

-

1

-

6

-

1

-

1

-

674669

Tu

A conserved histidine-aspartat ...

Nostoc sp., Nostoc sp. PCC 7120

J. Biol. Chem.

281

3127-3136

2006

-

1

-

16

-

1

-

18

-

1

-

1

2

-

1

-

1

-

16

-

1

-

1

-

1

2

-

674771

Zhao

Chromophore attachment to phyc ...

Anabaena sp., Anabaena sp. PCC 7120

J. Biol. Chem.

281

8573-8581

2006

-

1

-

18

-

2

-

1

-

1

-

2

-

676847

Hagiwara

Crystal structure of phycocyan ...

Synechocystis sp.

Proc. Natl. Acad. Sci. USA

103

27-32

2006

-

1

-

5

-

1

-

1

-

1

-

1

-

1

-

655796

Tu

Biliverdin reduction by cyanob ...

Anabaena sp.

J. Am. Chem. Soc.

126

8682-8693

2004

-

1

-

1

-

4

-

1

-

5

-

1

-

1

-

1

-

1

-

5

-

657164

Kami

Complementation of phytochrome ...

Synechocystis sp.

Proc. Natl. Acad. Sci. USA

101

1099-1104

2004

-

1

-

1

-

5

-

1

-

1

-

1

-

1

-

1

-

656197

Frankenberg

Phycocyanobilin:ferredoxin oxi ...

Anabaena sp.

J. Biol. Chem.

278

9219-9226

2003

-

1

-

2

1

-

7

-

4

1

-

1

-

2

1

-

4

1

-

437763

Tooley

Biosynthesis of the cyanobacte ...

Anabaena sp.

J. Bacteriol.

184

4666-4671

2002

-

1

-

1

-

1

-

1

-

1

-

437673

Frankenberg

Functional genomic analysis of ...

Anabaena sp., Prochlorococcus sp., Synechococcus sp., Synechocystis sp., Nostoc punctiforme, Prochlorococcus sp. CCMP1378 / MED4, Synechococcus sp. WH8102

Plant Cell

13

965-978

2001

-

5

-

2

-

8

-

5

-

7

-

5

-

2

-

5

-

7

-

437764

Tooley

Biosynthesis of a fluorescent ...

Synechocystis sp.

Proc. Natl. Acad. Sci. USA

98

10560-10565

2001

-

1

-

4

-

1

-

1

-

1

-

437765

Wu

Phycocyanobilin is the natural ...

Mesotaenium caldariorum

J. Biol. Chem.

272

25700-25705

1997

-

1

-

1

-

1

-

1

-

1

-

Effects of modified phycobilin biosynthesis in the cyanobacterium Synechococcus sp. strain PCC 7002

Data extracted from this reference: