Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,4-benzoquinone | 3.9fold selectivity for Schistosoma mansoni over human enzyme | Homo sapiens | |
1,4-benzoquinone | 3.9fold selectivity for Schistosoma mansoni over human enzyme | Schistosoma mansoni | |
2-(2,3-dichloroanilino)-3-hydroxynaphthalene-1,4-dione | 6.5fold selectivity for Schistosoma mansoni over human enzyme | Homo sapiens | |
2-(2,3-dichloroanilino)-3-hydroxynaphthalene-1,4-dione | 6.5fold selectivity for Schistosoma mansoni over human enzyme | Schistosoma mansoni | |
2-(2,6-dimethylanilino)-3-hydroxynaphthalene-1,4-dione | - |
Homo sapiens | |
2-(2,6-dimethylanilino)-3-hydroxynaphthalene-1,4-dione | - |
Schistosoma mansoni | |
2-(2-chloroanilino)-3-hydroxynaphthalene-1,4-dione | 10.4fold selectivity for Schistosoma mansoni over human enzyme | Homo sapiens | |
2-(2-chloroanilino)-3-hydroxynaphthalene-1,4-dione | 10.4fold selectivity for Schistosoma mansoni over human enzyme | Schistosoma mansoni | |
2-(3-chloroanilino)-3-hydroxynaphthalene-1,4-dione | 7fold selectivity for Schistosoma mansoni over human enzyme | Homo sapiens | |
2-(3-chloroanilino)-3-hydroxynaphthalene-1,4-dione | 7fold selectivity for Schistosoma mansoni over human enzyme | Schistosoma mansoni | |
2-(4-chloroanilino)-3-hydroxynaphthalene-1,4-dione | 2.9fold selectivity for Schistosoma mansoni over human enzyme | Homo sapiens | |
2-(4-chloroanilino)-3-hydroxynaphthalene-1,4-dione | 2.9fold selectivity for Schistosoma mansoni over human enzyme | Schistosoma mansoni | |
2-(4-fluoroanilino)-3-hydroxynaphthalene-1,4-dione | 3fold selectivity for human over Schistosoma mansoni enzyme | Homo sapiens | |
2-(4-fluoroanilino)-3-hydroxynaphthalene-1,4-dione | 3fold selectivity for human over Schistosoma mansoni enzyme | Schistosoma mansoni | |
2-anilino-3-hydroxynaphthalene-1,4-dione | - |
Homo sapiens | |
2-anilino-3-hydroxynaphthalene-1,4-dione | - |
Schistosoma mansoni | |
2-chloro-3-(methylamino)naphthalene-1,4-dione | - |
Homo sapiens | |
2-chloro-3-(methylamino)naphthalene-1,4-dione | - |
Schistosoma mansoni | |
2-hydroxy-3-(3-methylbutyl)naphthalene-1,4-dione | 30.8fold selectivity for Schistosoma mansoni over human enzyme | Homo sapiens | |
2-hydroxy-3-(3-methylbutyl)naphthalene-1,4-dione | 30.8fold selectivity for Schistosoma mansoni over human enzyme | Schistosoma mansoni | |
2-hydroxy-3-(4-methoxyanilino)naphthalene-1,4-dione | - |
Homo sapiens | |
2-hydroxy-3-(4-methoxyanilino)naphthalene-1,4-dione | - |
Schistosoma mansoni | |
2-hydroxy-3-(4-phenylpiperazin-1-yl)naphthalene-1,4-dione | 9.6fold selectivity for Schistosoma mansoni over human enzyme | Homo sapiens | |
2-hydroxy-3-(4-phenylpiperazin-1-yl)naphthalene-1,4-dione | 9.6fold selectivity for Schistosoma mansoni over human enzyme | Schistosoma mansoni | |
2-hydroxy-3-[3-(trifluoromethyl)anilino]naphthalene-1,4-dione | - |
Homo sapiens | |
2-hydroxy-3-[3-(trifluoromethyl)anilino]naphthalene-1,4-dione | - |
Schistosoma mansoni | |
2-hydroxy-3-[4-(4-nitrophenyl)piperazin-1-yl]naphthalene-1,4-dione | - |
Homo sapiens | |
2-hydroxy-3-[4-(4-nitrophenyl)piperazin-1-yl]naphthalene-1,4-dione | - |
Schistosoma mansoni | |
2-methylcyclohexa-2,5-diene-1,4-dione | - |
Schistosoma mansoni | |
2-tert-butylcyclohexa-2,5-diene-1,4-dione | - |
Schistosoma mansoni | |
2-[(2,3-dihydro-1,4-benzodioxin-6-yl)amino]-3-hydroxynaphthalene-1,4-dione | 2fold selectivity for human over Schistosoma mansoni enzyme | Homo sapiens | |
2-[(2,3-dihydro-1,4-benzodioxin-6-yl)amino]-3-hydroxynaphthalene-1,4-dione | 2fold selectivity for human over Schistosoma mansoni enzyme | Schistosoma mansoni | |
2-[(2H-1,3-benzodioxol-5-yl)amino]-3-hydroxynaphthalene-1,4-dione | - |
Homo sapiens | |
2-[(2H-1,3-benzodioxol-5-yl)amino]-3-hydroxynaphthalene-1,4-dione | - |
Schistosoma mansoni | |
2-[4-(2,3-dichlorophenyl)piperazin-1-yl]-3-hydroxynaphthalene-1,4-dione | 4.1fold selectivity for Schistosoma mansoni over human enzyme | Homo sapiens | |
2-[4-(2,3-dichlorophenyl)piperazin-1-yl]-3-hydroxynaphthalene-1,4-dione | 4.1fold selectivity for Schistosoma mansoni over human enzyme | Schistosoma mansoni | |
2-[4-(4-chlorophenyl)piperazin-1-yl]-3-hydroxynaphthalene-1,4-dione | 20.3fold selectivity for Schistosoma mansoni over human enzyme | Homo sapiens | |
2-[4-(4-chlorophenyl)piperazin-1-yl]-3-hydroxynaphthalene-1,4-dione | 20.3fold selectivity for Schistosoma mansoni over human enzyme | Schistosoma mansoni | |
3-(3-methylbut-2-en-1-yl)-1,4-dioxo-1,4-dihydronaphthalen-2-yl 4-methylbenzene-1-sulfonate | 4.0fold selectivity for human over Schistosoma mansoni enzyme | Homo sapiens | |
3-(3-methylbut-2-en-1-yl)-1,4-dioxo-1,4-dihydronaphthalen-2-yl 4-methylbenzene-1-sulfonate | 4.0fold selectivity for human over Schistosoma mansoni enzyme | Schistosoma mansoni | |
atovaquone | 6.3fold selectivity for Schistosoma mansoni over human enzyme | Homo sapiens | |
atovaquone | 6.3fold selectivity for Schistosoma mansoni over human enzyme | Schistosoma mansoni | |
brequinar | 540fold selectivity for human over Schistosoma mansoni enzyme | Homo sapiens | |
brequinar | 540fold selectivity for human over Schistosoma mansoni enzyme | Schistosoma mansoni | |
isolapachol | 8.3fold selectivity for Schistosoma mansoni over human enzyme | Homo sapiens | |
isolapachol | 8.3fold selectivity for Schistosoma mansoni over human enzyme | Schistosoma mansoni | |
Lapachol | 5.3fold selectivity for Schistosoma mansoni over human enzyme | Homo sapiens | |
Lapachol | 5.3fold selectivity for Schistosoma mansoni over human enzyme | Schistosoma mansoni | |
Lawsone | - |
Homo sapiens | |
Lawsone | - |
Schistosoma mansoni | |
teriflunomide | 160fold selectivity for human over Schistosoma mansoni enzyme | Homo sapiens | |
teriflunomide | 160fold selectivity for human over Schistosoma mansoni enzyme | Schistosoma mansoni | |
[[3-(3-methylbut-2-en-1-yl)-1,4-dioxo-1,4-dihydronaphthalen-2-yl]oxy]acetonitrile | - |
Homo sapiens | |
[[3-(3-methylbut-2-en-1-yl)-1,4-dioxo-1,4-dihydronaphthalen-2-yl]oxy]acetonitrile | - |
Schistosoma mansoni |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q02127 | - |
- |
Schistosoma mansoni | G4VFD7 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dihydroorotate + coenzyme Q0 | - |
Homo sapiens | orotate + reduced coenzyme Q0 | - |
? | |
dihydroorotate + coenzyme Q0 | - |
Schistosoma mansoni | orotate + reduced coenzyme Q0 | - |
? |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000019 | - |
pH 8.2, 25°C | Schistosoma mansoni | Lapachol | |
0.000023 | - |
pH 8.2, 25°C | Schistosoma mansoni | 2-hydroxy-3-(3-methylbutyl)naphthalene-1,4-dione | |
0.000037 | - |
pH 8.2, 25°C | Homo sapiens | brequinar | |
0.000078 | - |
pH 8.2, 25°C | Schistosoma mansoni | 2-(2-chloroanilino)-3-hydroxynaphthalene-1,4-dione | |
0.0001 | - |
pH 8.2, 25°C | Homo sapiens | Lapachol | |
0.000108 | - |
pH 8.2, 25°C | Homo sapiens | 2-hydroxy-3-[3-(trifluoromethyl)anilino]naphthalene-1,4-dione | |
0.000111 | - |
pH 8.2, 25°C | Schistosoma mansoni | 2-hydroxy-3-[3-(trifluoromethyl)anilino]naphthalene-1,4-dione | |
0.000123 | - |
pH 8.2, 25°C | Homo sapiens | 2-(2,3-dichloroanilino)-3-hydroxynaphthalene-1,4-dione | |
0.000129 | - |
pH 8.2, 25°C | Schistosoma mansoni | 2-(3-chloroanilino)-3-hydroxynaphthalene-1,4-dione | |
0.000185 | - |
pH 8.2, 25°C | Schistosoma mansoni | 2-(4-chloroanilino)-3-hydroxynaphthalene-1,4-dione | |
0.00019 | - |
pH 8.2, 25°C | Schistosoma mansoni | 2-(2,3-dichloroanilino)-3-hydroxynaphthalene-1,4-dione | |
0.00028 | - |
pH 8.2, 25°C | Schistosoma mansoni | 2-[4-(4-chlorophenyl)piperazin-1-yl]-3-hydroxynaphthalene-1,4-dione | |
0.000312 | - |
pH 8.2, 25°C | Homo sapiens | teriflunomide | |
0.00033 | - |
pH 8.2, 25°C | Homo sapiens | 2-(4-fluoroanilino)-3-hydroxynaphthalene-1,4-dione | |
0.00038 | - |
pH 8.2, 25°C | Schistosoma mansoni | 2-hydroxy-3-[4-(4-nitrophenyl)piperazin-1-yl]naphthalene-1,4-dione | |
0.00043 | - |
pH 8.2, 25°C | Schistosoma mansoni | atovaquone | |
0.00044 | - |
pH 8.2, 25°C | Schistosoma mansoni | 2-[4-(2,3-dichlorophenyl)piperazin-1-yl]-3-hydroxynaphthalene-1,4-dione | |
0.000541 | - |
pH 8.2, 25°C | Homo sapiens | 2-(4-chloroanilino)-3-hydroxynaphthalene-1,4-dione | |
0.000709 | - |
pH 8.2, 25°C | Homo sapiens | 2-hydroxy-3-(3-methylbutyl)naphthalene-1,4-dione | |
0.000711 | - |
pH 8.2, 25°C | Schistosoma mansoni | 2-hydroxy-3-(4-phenylpiperazin-1-yl)naphthalene-1,4-dione | |
0.000808 | - |
pH 8.2, 25°C | Homo sapiens | 2-(2-chloroanilino)-3-hydroxynaphthalene-1,4-dione | |
0.000911 | - |
pH 8.2, 25°C | Homo sapiens | 2-(3-chloroanilino)-3-hydroxynaphthalene-1,4-dione | |
0.001 | - |
pH 8.2, 25°C | Schistosoma mansoni | 2-(4-fluoroanilino)-3-hydroxynaphthalene-1,4-dione | |
0.00105 | - |
pH 8.2, 25°C | Homo sapiens | 2-[(2,3-dihydro-1,4-benzodioxin-6-yl)amino]-3-hydroxynaphthalene-1,4-dione | |
0.0012 | - |
pH 8.2, 25°C | Schistosoma mansoni | isolapachol | |
0.0018 | - |
pH 8.2, 25°C | Homo sapiens | 2-[4-(2,3-dichlorophenyl)piperazin-1-yl]-3-hydroxynaphthalene-1,4-dione | |
0.0021 | - |
pH 8.2, 25°C | Schistosoma mansoni | 2-anilino-3-hydroxynaphthalene-1,4-dione | |
0.0021 | - |
pH 8.2, 25°C | Schistosoma mansoni | 2-[(2,3-dihydro-1,4-benzodioxin-6-yl)amino]-3-hydroxynaphthalene-1,4-dione | |
0.0025 | - |
pH 8.2, 25°C | Schistosoma mansoni | [[3-(3-methylbut-2-en-1-yl)-1,4-dioxo-1,4-dihydronaphthalen-2-yl]oxy]acetonitrile | |
0.0026 | - |
pH 8.2, 25°C | Homo sapiens | 2-anilino-3-hydroxynaphthalene-1,4-dione | |
0.0027 | - |
pH 8.2, 25°C | Homo sapiens | atovaquone | |
0.0036 | - |
pH 8.2, 25°C | Homo sapiens | 2-[(2H-1,3-benzodioxol-5-yl)amino]-3-hydroxynaphthalene-1,4-dione | |
0.0046 | - |
pH 8.2, 25°C | Homo sapiens | 2-[4-(4-chlorophenyl)piperazin-1-yl]-3-hydroxynaphthalene-1,4-dione | |
0.0047 | - |
pH 8.2, 25°C | Schistosoma mansoni | 2-hydroxy-3-(4-methoxyanilino)naphthalene-1,4-dione | |
0.0055 | - |
pH 8.2, 25°C | Schistosoma mansoni | 2-[(2H-1,3-benzodioxol-5-yl)amino]-3-hydroxynaphthalene-1,4-dione | |
0.0068 | - |
pH 8.2, 25°C | Homo sapiens | 2-hydroxy-3-(4-phenylpiperazin-1-yl)naphthalene-1,4-dione | |
0.0079 | - |
pH 8.2, 25°C | Homo sapiens | 3-(3-methylbut-2-en-1-yl)-1,4-dioxo-1,4-dihydronaphthalen-2-yl 4-methylbenzene-1-sulfonate | |
0.0088 | - |
pH 8.2, 25°C | Schistosoma mansoni | 1,4-benzoquinone | |
0.0099 | - |
pH 8.2, 25°C | Schistosoma mansoni | 2-(2,6-dimethylanilino)-3-hydroxynaphthalene-1,4-dione | |
0.01 | - |
pH 8.2, 25°C | Homo sapiens | 2-(2,6-dimethylanilino)-3-hydroxynaphthalene-1,4-dione | |
0.01 | - |
pH 8.2, 25°C | Homo sapiens | isolapachol | |
0.02 | - |
pH 8.2, 25°C | Schistosoma mansoni | brequinar | |
0.029 | - |
pH 8.2, 25°C | Schistosoma mansoni | Lawsone | |
0.0314 | - |
pH 8.2, 25°C | Schistosoma mansoni | 3-(3-methylbut-2-en-1-yl)-1,4-dioxo-1,4-dihydronaphthalen-2-yl 4-methylbenzene-1-sulfonate | |
0.034 | - |
pH 8.2, 25°C | Homo sapiens | 1,4-benzoquinone | |
0.05 | - |
pH 8.2, 25°C | Schistosoma mansoni | teriflunomide | |
0.057 | - |
pH 8.2, 25°C | Schistosoma mansoni | 2-methylcyclohexa-2,5-diene-1,4-dione | |
0.079 | - |
pH 8.2, 25°C | Schistosoma mansoni | 2-chloro-3-(methylamino)naphthalene-1,4-dione | |
0.768 | - |
pH 8.2, 25°C | Schistosoma mansoni | 2-tert-butylcyclohexa-2,5-diene-1,4-dione |