Application | Comment | Organism |
---|---|---|
additional information | three types of hydrogen bonding pathways, hydrogen bonding of the active base serine to a water molecule, which is hydrogen bonded to the substrate carboxylate group or a threonine residue, the threonine residue is positioned to enable proton transfer to another water molecule leading to the bulk solvent | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
S215C | increase of the average donor-acceptor distances for proton and hydride transfer and disruption of the hydrogen bonding pathways observed for the wild-type enzyme, significant decrease in enzyme activity | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q02127 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dihydroorotate + acceptor | - |
Homo sapiens | orotate + reduced acceptor | - |
? | |
additional information | computational method to investigate potential proton relay pathways in the active site of the enzyme | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DHOD | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
flavin | - |
Homo sapiens | |
FMN | Lys100 and Lys225 enhance the structural stability of the active site by hydrogen bonding to the FMN cofactor | Homo sapiens |