Literature summary for 1.3.5.2 extracted from

Hansen, M.; Le Nours, J.; Johansson, E.; Antal, T.; Ullrich, A.; Loffler, M.; Larsen, S.
Inhibitor binding in a class 2 dihydroorotate dehydrogenase causes variations in the membrane-associated N-terminal domain (2004), Protein Sci., 13, 1031-1042.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
mutant DELTA1-29 in complex with brequinar and with atovaquone	Rattus norvegicus

Protein Variants

Protein Variants	Comment	Organism
DELTA1-29	deletion of N-terminal 29 amino acids	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
atovaquone	50% inhibition at 0.000698 mM, wild-type enzyme, 0.000904 mM, DELTA1-29 mutant	Rattus norvegicus
brequinar	50% inhibition at 0.000367 mM, wild-type enzyme, 0.000127 mM, DELTA1-29 mutant	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	recombinant wild-type enzyme and N-terminally truncated form	-

Subunits

Subunits	Comment	Organism
monomer	folds into small N-terminal domain and an (alphabeta)8 barrel comprising the C-terminal domain, crystallization data	Rattus norvegicus

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Release 2023.1 (January 2023)