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Literature summary for 1.3.5.2 extracted from
- Structures of human dihydroorotate dehydrogenase in complex with antiproliferative agents (2000), Structure, 8, 25-33.
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| brequinar sodium | - |
Homo sapiens |  |
| leflunomide | - |
Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| (S)-dihydroorotate + a quinone = orotate + a quinol | fourth step in biosynthesis of pyrimidines. Two domains: alpha/beta-barrel domain containing the active site, one alpha-helical domain that forms the opening of a tunnel leading to active site | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DHODH | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FMN | tightly bound | Homo sapiens | |
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Release 2023.1 (January 2023)
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