Literature summary for 1.3.5.1 extracted from

Kassem, I.; Khatri, M.; Sanad, Y.; Wolboldt, M.; Saif, Y.; Olson, J.; Rajashekara, G.
The impairment of methylmenaquinol Fumarate reductase affects hydrogen peroxide susceptibility and accumulation in Campylobacter jejuni (2014), MicrobiologyOpen, 3, 168-181 .

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Organism

Organism	UniProt	Comment	Textmining
Campylobacter jejuni subsp. jejuni	-	-	-

Synonyms

Synonyms	Comment	Organism
MfrA	-	Campylobacter jejuni subsp. jejuni
MfrB	-	Campylobacter jejuni subsp. jejuni

General Information

General Information	Comment	Organism
physiological function	a subunit MfrA mutant strain is less susceptible to H2O2 as the wildtype. The H2O2 concentration in the mutant cultures is significantly higher than that of wild-type. In the presence of H2O2, catalase activity and expression are lower in the mutant strain as compared to the wild-type. Exposure to H2O2 results in a significant decrease in total intracellular iron in the mutant strain, while the addition of iron to the growth medium mitigates H2O2 susceptibility and accumulation in the mutant. The mutant strain is significantly more persistent in RAW macrophages	Campylobacter jejuni subsp. jejuni

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Release 2023.1 (January 2023)