Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.3.5.1 extracted from

  • Pecsi, I.; Hards, K.; Ekanayaka, N.; Berney, M.; Hartman, T.; Jacobs, W.R.; Cook, G.M.
    Essentiality of succinate dehydrogenase in Mycobacterium smegmatis and its role in the generation of the membrane potential under hypoxia (2014), mBio, 5, e01093 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
3-nitropropanoate treatment with 3-nitroproprionate dissipates the membrane potential of wild-type or Sdh1 mutant cells under hypoxia but not that of cells grown aerobically Mycolicibacterium smegmatis

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Mycolicibacterium smegmatis 16020
-

Organism

Organism UniProt Comment Textmining
Mycolicibacterium smegmatis A0QPJ1 and A0QPJ2 and A0QPJ3 and A0QPJ4 and A0QPJ5 isoform Sdh1 is encoded by a five-gene operon. A0QPJ1 i.e. gene MSMEG_0416, A0QPJ2 i.e. gene MSMEG_0417, A0QPJ3 i.e. gene MSMEG_0418, A0QPJ4 i.e. gene MSMEG_0419, A0QPJ5 i.e. gene MSMEG_0420
-
Mycolicibacterium smegmatis A0QT07 and A0QT08 and A0QT09 and A0QT10 isoform Sdh2 is encoded by a five-gene operon. A0QT07 i.e. gene MSMEG_1669, A0QT08 i.e. gene MSMEG_1670, A0QT09 i.e. gene MSMEG_1671, A0QT10 i.e. gene MSMEG_1672
-
Mycolicibacterium smegmatis ATCC 700084 A0QPJ1 and A0QPJ2 and A0QPJ3 and A0QPJ4 and A0QPJ5 isoform Sdh1 is encoded by a five-gene operon. A0QPJ1 i.e. gene MSMEG_0416, A0QPJ2 i.e. gene MSMEG_0417, A0QPJ3 i.e. gene MSMEG_0418, A0QPJ4 i.e. gene MSMEG_0419, A0QPJ5 i.e. gene MSMEG_0420
-
Mycolicibacterium smegmatis ATCC 700084 A0QT07 and A0QT08 and A0QT09 and A0QT10 isoform Sdh2 is encoded by a five-gene operon. A0QT07 i.e. gene MSMEG_1669, A0QT08 i.e. gene MSMEG_1670, A0QT09 i.e. gene MSMEG_1671, A0QT10 i.e. gene MSMEG_1672
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
succinate + 2,6-dichlorophenolindophenol
-
Mycolicibacterium smegmatis fumarate + reduced 2,6-dichlorophenolindophenol
-
ir
succinate + 2,6-dichlorophenolindophenol
-
Mycolicibacterium smegmatis ATCC 700084 fumarate + reduced 2,6-dichlorophenolindophenol
-
ir

Synonyms

Synonyms Comment Organism
MSMEG_0416
-
Mycolicibacterium smegmatis
MSMEG_0417
-
Mycolicibacterium smegmatis
MSMEG_0418
-
Mycolicibacterium smegmatis
MSMEG_0419
-
Mycolicibacterium smegmatis
MSMEG_0420
-
Mycolicibacterium smegmatis
MSMEG_1669
-
Mycolicibacterium smegmatis
MSMEG_1670
-
Mycolicibacterium smegmatis
MSMEG_1671
-
Mycolicibacterium smegmatis
MSMEG_1672
-
Mycolicibacterium smegmatis
SDH1
-
Mycolicibacterium smegmatis
SDH2
-
Mycolicibacterium smegmatis

General Information

General Information Comment Organism
physiological function deletion of the sdh1 operon does not yield any growth phenotypes on succinate or other nonfermentable carbon sources Mycolicibacterium smegmatis
physiological function presence of the Sdh2 operon is essential for growth. Isoform Sdh2 is the generator of the membrane potential under hypoxia Mycolicibacterium smegmatis