Any feedback?
Literature summary for 1.3.5.1 extracted from
- Mutations in the C. elegans succinate dehydrogenase iron-sulfur subunit promote superoxide generation and premature aging (2009), J. Mol. Biol., 387, 559-569.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| P211F | mutant shows significant reduced SDH activity, mutant shows significant shorter life span compared to wild-type, embryogenesis is impaired in mutant (dead embryos all arrest before the four-cell stage), mutant shows an increased hypersensitivity to oxidative stress compared to wild-type, respiration rate is significantly decreased in mutant compared to wild-type, mitochondria of mutant generate significantly more superoxide compared to wild-type | Caenorhabditis elegans |
| P211H | mutant shows significant reduced SDH activity, mutant shows significant shorter life span compared to wild-type, embryogenesis is impaired in mutant (dead embryos all arrest before the four-cell stage), mutant shows an increased hypersensitivity to oxidative stress compared to wild-type, respiration rate is significantly decreased in mutant compared to wild-type, mitochondria of mutant generate significantly more superoxide compared to wild-type | Caenorhabditis elegans |
| P211L | mutant shows the weakest SDH activity, mutant shows a significant shorter life span compared to wild-type, embryogenesis is impaired in mutant (dead embryos all arrest before the four-cell stage), mutant shows an increased hypersensitivity to oxidative stress compared to wild-type, respiration rate in P211L mutant is increased compared to wild-type, mitochondria of mutant generate significantly more superoxide compared to wild-type | Caenorhabditis elegans |
| P211N | mutant shows significant reduced SDH activity, embryogenesis is impaired in mutant (dead embryos all arrest before the four-cell stage), mutant shows an increased hypersensitivity to oxidative stress compared to wild-type | Caenorhabditis elegans |
| P211Q | mutant shows significant reduced SDH activity, embryogenesis is impaired in mutant (dead embryos all arrest before the four-cell stage), mutant shows an increased hypersensitivity to oxidative stress compared to wild-type | Caenorhabditis elegans |
| P211R | mutant shows significant reduced SDH activity, life span of mutant is not reduced compared to wild-type, embryogenesis is impaired in mutant, in P211R mutant are twice as many dead embryos compared to wild-type (dead embryos all arrest before the four-cell stage), mutant shows an increased hypersensitivity to oxidative stress compared to wild-type, mitochondria of mutant generate significantly more superoxide compared to wild-type | Caenorhabditis elegans |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Caenorhabditis elegans | 5739 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Caenorhabditis elegans | Q09545 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | for enzymatic activity the succinate-dependent, phenazine methosulfate-mediated reduction of dichlorophenol indophenol of crude mitochondrial fractions prepared from the wild type and the P211 mutants is measured | Caenorhabditis elegans | ? | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SDH | - |
Caenorhabditis elegans |
| succinate dehydrogenase | - |
Caenorhabditis elegans |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Caenorhabditis elegans |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
