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Literature summary for 1.3.5.1 extracted from

  • Selby, T.P.; Hughes, K.A.; Rauh, J.J.; Hanna, W.S.
    Synthetic atpenin analogs: Potent mitochondrial inhibitors of mammalian and fungal succinate-ubiquinone oxidoreductase (2010), Bioorg. Med. Chem. Lett., 20, 1665-1668.
    View publication on PubMed
Search for more literature for 1.3.5.1

Inhibitors

Inhibitors Comment Organism Structure
(2,4-dihydroxy-5,6-dimethoxypyridin-3-yl)(3-phenoxyphenyl)methanone
-
 Bos taurus
(2,4-dihydroxy-5,6-dimethoxypyridin-3-yl)(3-phenoxyphenyl)methanone
-
 Parastagonospora nodorum
(4-chlorophenyl)(2,4-dihydroxy-5,6-dimethoxypyridin-3-yl)methanone
-
 Bos taurus
(4-chlorophenyl)(2,4-dihydroxy-5,6-dimethoxypyridin-3-yl)methanone
-
 Parastagonospora nodorum
1-(2,4-dihydroxy-5,6-dimethoxypyridin-3-yl)-2,2-diphenylethanone
-
 Bos taurus
1-(2,4-dihydroxy-5,6-dimethoxypyridin-3-yl)-2,2-diphenylethanone
-
 Parastagonospora nodorum
1-(2,4-dihydroxy-5,6-dimethoxypyridin-3-yl)-2,6-dimethylhept-5-en-1-one
-
 Bos taurus
1-(2,4-dihydroxy-5,6-dimethoxypyridin-3-yl)-2,6-dimethylhept-5-en-1-one
-
 Parastagonospora nodorum
1-(2,4-dihydroxy-5,6-dimethoxypyridin-3-yl)-2-ethylhexan-1-one
-
 Bos taurus
1-(2,4-dihydroxy-5,6-dimethoxypyridin-3-yl)-2-ethylhexan-1-one
-
 Parastagonospora nodorum
1-(2,4-dihydroxy-5,6-dimethoxypyridin-3-yl)-2-methylbutan-1-one
-
 Bos taurus
1-(2,4-dihydroxy-5,6-dimethoxypyridin-3-yl)-2-methylbutan-1-one
-
 Parastagonospora nodorum
1-(2,4-dihydroxy-5,6-dimethoxypyridin-3-yl)-2-methylhexan-1-one
-
 Bos taurus
1-(2,4-dihydroxy-5,6-dimethoxypyridin-3-yl)-2-methylhexan-1-one
-
 Parastagonospora nodorum
1-(2,4-dihydroxy-5,6-dimethoxypyridin-3-yl)-2-methylundecan-1-one
-
 Bos taurus
1-(2,4-dihydroxy-5,6-dimethoxypyridin-3-yl)-2-methylundecan-1-one
-
 Parastagonospora nodorum
1-(2,4-dihydroxy-5,6-dimethoxypyridin-3-yl)-2-phenylpropan-1-one
-
 Bos taurus
1-(2,4-dihydroxy-5,6-dimethoxypyridin-3-yl)-2-phenylpropan-1-one
-
 Parastagonospora nodorum
2,3-dimethoxy-5-(2-methylbutanoyl)pyridin-4(1H)-one
-
 Bos taurus
2,3-dimethoxy-5-(2-methylbutanoyl)pyridin-4(1H)-one
-
 Parastagonospora nodorum
2,3-dimethoxy-5-(naphthalen-2-ylcarbonyl)pyridin-4(1H)-one
-
 Bos taurus
2,3-dimethoxy-5-(naphthalen-2-ylcarbonyl)pyridin-4(1H)-one
-
 Parastagonospora nodorum
2,3-dimethoxy-5-[(2-phenoxyphenyl)carbonyl]pyridin-4(1H)-one
-
 Bos taurus
2,3-dimethoxy-5-[(2-phenoxyphenyl)carbonyl]pyridin-4(1H)-one
-
 Parastagonospora nodorum
2,3-dimethoxy-5-[(3-phenoxyphenyl)carbonyl]pyridin-4(1H)-one
-
 Bos taurus
2,3-dimethoxy-5-[(3-phenoxyphenyl)carbonyl]pyridin-4(1H)-one
-
 Parastagonospora nodorum
2,3-dimethoxy-5-[(4-methoxyphenyl)carbonyl]pyridin-4(1H)-one
-
 Bos taurus
2,3-dimethoxy-5-[(4-methoxyphenyl)carbonyl]pyridin-4(1H)-one
-
 Parastagonospora nodorum
2,3-dimethoxy-5-[(4-phenoxyphenyl)carbonyl]pyridin-4(1H)-one
-
 Bos taurus
2,3-dimethoxy-5-[(4-phenoxyphenyl)carbonyl]pyridin-4(1H)-one
-
 Parastagonospora nodorum
2-bromo-3-[(4-chlorophenyl)carbonyl]-5,6-dimethoxypyridin-4(1H)-one
-
 Bos taurus
2-bromo-3-[(4-chlorophenyl)carbonyl]-5,6-dimethoxypyridin-4(1H)-one
-
 Parastagonospora nodorum
3-(4-tert-butylphenyl)-1-(2,4-dihydroxy-5,6-dimethoxypyridin-3-yl)-2-methylpropan-1-one
-
 Bos taurus
3-(4-tert-butylphenyl)-1-(2,4-dihydroxy-5,6-dimethoxypyridin-3-yl)-2-methylpropan-1-one
-
 Parastagonospora nodorum
3-[(4-chlorophenyl)carbonyl]-2,5,6-trimethoxypyridin-4(1H)-one
-
 Bos taurus
3-[(4-chlorophenyl)carbonyl]-2,5,6-trimethoxypyridin-4(1H)-one
-
 Parastagonospora nodorum
3-[(4-chlorophenyl)carbonyl]-5,6-dimethoxy-2-methylpyridin-4(1H)-one
-
 Bos taurus
3-[(4-chlorophenyl)carbonyl]-5,6-dimethoxy-2-methylpyridin-4(1H)-one
-
 Parastagonospora nodorum
3-[(4-chlorophenyl)carbonyl]-5,6-dimethoxypyridine-2,4-diyl diacetate
-
 Bos taurus
3-[(4-chlorophenyl)carbonyl]-5,6-dimethoxypyridine-2,4-diyl diacetate
-
 Parastagonospora nodorum
3-[(4-chlorophenyl)carbonyl]-5,6-dimethoxypyridine-2,4-diyl dimethanesulfonate
-
 Bos taurus
3-[(4-chlorophenyl)carbonyl]-5,6-dimethoxypyridine-2,4-diyl dimethanesulfonate
-
 Parastagonospora nodorum
5-(biphenyl-4-ylcarbonyl)-2,3-dimethoxypyridin-4(1H)-one
-
 Bos taurus
5-(biphenyl-4-ylcarbonyl)-2,3-dimethoxypyridin-4(1H)-one
-
 Parastagonospora nodorum
5-[(2-chlorophenyl)carbonyl]-2,3-dimethoxypyridin-4(1H)-one
-
 Bos taurus
5-[(2-chlorophenyl)carbonyl]-2,3-dimethoxypyridin-4(1H)-one
-
 Parastagonospora nodorum
5-[(3-chlorophenyl)carbonyl]-2,3-dimethoxypyridin-4(1H)-one
-
 Bos taurus
5-[(3-chlorophenyl)carbonyl]-2,3-dimethoxypyridin-4(1H)-one
-
 Parastagonospora nodorum
5-[(4-chlorophenyl)carbonyl]-2,3-dimethoxypyridin-4(1H)-one
-
 Bos taurus
5-[(4-chlorophenyl)carbonyl]-2,3-dimethoxypyridin-4(1H)-one
-
 Parastagonospora nodorum
atpenin A5
-
 Bos taurus
atpenin A5
-
 Parastagonospora nodorum
boscalid
-
 Bos taurus
boscalid
-
 Parastagonospora nodorum
cyclohexyl(2,4-dihydroxy-5,6-dimethoxypyridin-3-yl)methanone
-
 Bos taurus
cyclohexyl(2,4-dihydroxy-5,6-dimethoxypyridin-3-yl)methanone
-
 Parastagonospora nodorum

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion mitochondria from Septoria nodorum are prepared Parastagonospora nodorum 5739
-
mitochondrion mitochondrion from bovine heart are prepared Bos taurus 5739
-

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Parastagonospora nodorum
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
succinate + decylubiquinone
-
 Bos taurus fumarate + decylubiquinol
-
 ?
succinate + decylubiquinone
-
 Parastagonospora nodorum fumarate + decylubiquinol
-
 ?

Synonyms

Synonyms Comment Organism
SQR
-
 Bos taurus
SQR
-
 Parastagonospora nodorum
succinate-quinone oxidoreductase
-
 Bos taurus
succinate-quinone oxidoreductase
-
 Parastagonospora nodorum

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000003
-
-
 Bos taurus 1-(2,4-dihydroxy-5,6-dimethoxypyridin-3-yl)-2-methylundecan-1-one
0.000004
-
-
 Bos taurus atpenin A5
0.000004
-
-
 Parastagonospora nodorum 1-(2,4-dihydroxy-5,6-dimethoxypyridin-3-yl)-2-methylundecan-1-one
0.00001
-
-
 Bos taurus 1-(2,4-dihydroxy-5,6-dimethoxypyridin-3-yl)-2,6-dimethylhept-5-en-1-one
0.00001
-
-
 Bos taurus 1-(2,4-dihydroxy-5,6-dimethoxypyridin-3-yl)-2-phenylpropan-1-one
0.00001
-
-
 Bos taurus 3-(4-tert-butylphenyl)-1-(2,4-dihydroxy-5,6-dimethoxypyridin-3-yl)-2-methylpropan-1-one
0.000011
-
-
 Parastagonospora nodorum atpenin A5
0.00002
-
-
 Bos taurus 1-(2,4-dihydroxy-5,6-dimethoxypyridin-3-yl)-2-methylhexan-1-one
0.000024
-
-
 Parastagonospora nodorum 3-(4-tert-butylphenyl)-1-(2,4-dihydroxy-5,6-dimethoxypyridin-3-yl)-2-methylpropan-1-one
0.000051
-
-
 Parastagonospora nodorum 1-(2,4-dihydroxy-5,6-dimethoxypyridin-3-yl)-2,6-dimethylhept-5-en-1-one
0.0001
-
-
 Bos taurus 1-(2,4-dihydroxy-5,6-dimethoxypyridin-3-yl)-2-methylbutan-1-one
0.00011
-
-
 Bos taurus (2,4-dihydroxy-5,6-dimethoxypyridin-3-yl)(3-phenoxyphenyl)methanone
0.000122
-
-
 Parastagonospora nodorum 1-(2,4-dihydroxy-5,6-dimethoxypyridin-3-yl)-2-methylhexan-1-one
0.00013
-
-
 Bos taurus cyclohexyl(2,4-dihydroxy-5,6-dimethoxypyridin-3-yl)methanone
0.00013
-
-
 Bos taurus 1-(2,4-dihydroxy-5,6-dimethoxypyridin-3-yl)-2-ethylhexan-1-one
0.000234
-
-
 Parastagonospora nodorum 1-(2,4-dihydroxy-5,6-dimethoxypyridin-3-yl)-2-ethylhexan-1-one
0.000245
-
-
 Parastagonospora nodorum boscalid
0.000299
-
-
 Parastagonospora nodorum 1-(2,4-dihydroxy-5,6-dimethoxypyridin-3-yl)-2-phenylpropan-1-one
0.00033
-
-
 Bos taurus (4-chlorophenyl)(2,4-dihydroxy-5,6-dimethoxypyridin-3-yl)methanone
0.00045
-
-
 Bos taurus 2,3-dimethoxy-5-[(3-phenoxyphenyl)carbonyl]pyridin-4(1H)-one
0.00049
-
-
 Bos taurus 2,3-dimethoxy-5-[(4-phenoxyphenyl)carbonyl]pyridin-4(1H)-one
0.00063
-
-
 Bos taurus 1-(2,4-dihydroxy-5,6-dimethoxypyridin-3-yl)-2,2-diphenylethanone
0.0008
-
-
 Bos taurus 5-(biphenyl-4-ylcarbonyl)-2,3-dimethoxypyridin-4(1H)-one
0.00127
-
-
 Bos taurus 2-bromo-3-[(4-chlorophenyl)carbonyl]-5,6-dimethoxypyridin-4(1H)-one
0.00178
-
-
 Parastagonospora nodorum cyclohexyl(2,4-dihydroxy-5,6-dimethoxypyridin-3-yl)methanone
0.00179
-
-
 Bos taurus boscalid
0.00194
-
-
 Parastagonospora nodorum 2-bromo-3-[(4-chlorophenyl)carbonyl]-5,6-dimethoxypyridin-4(1H)-one
0.00233
-
-
 Parastagonospora nodorum (2,4-dihydroxy-5,6-dimethoxypyridin-3-yl)(3-phenoxyphenyl)methanone
0.00258
-
-
 Parastagonospora nodorum 1-(2,4-dihydroxy-5,6-dimethoxypyridin-3-yl)-2-methylbutan-1-one
0.00275
-
-
 Parastagonospora nodorum 5-(biphenyl-4-ylcarbonyl)-2,3-dimethoxypyridin-4(1H)-one
0.00298
-
-
 Parastagonospora nodorum 2,3-dimethoxy-5-[(3-phenoxyphenyl)carbonyl]pyridin-4(1H)-one
0.0034
-
-
 Bos taurus 5-[(4-chlorophenyl)carbonyl]-2,3-dimethoxypyridin-4(1H)-one
0.00408
-
-
 Parastagonospora nodorum 2,3-dimethoxy-5-[(4-phenoxyphenyl)carbonyl]pyridin-4(1H)-one
0.00656
-
-
 Bos taurus 5-[(3-chlorophenyl)carbonyl]-2,3-dimethoxypyridin-4(1H)-one
0.0128
-
-
 Bos taurus 2,3-dimethoxy-5-(naphthalen-2-ylcarbonyl)pyridin-4(1H)-one
0.0138
-
-
 Bos taurus 3-[(4-chlorophenyl)carbonyl]-5,6-dimethoxy-2-methylpyridin-4(1H)-one
0.0139
-
-
 Parastagonospora nodorum 3-[(4-chlorophenyl)carbonyl]-5,6-dimethoxy-2-methylpyridin-4(1H)-one
0.0207
-
-
 Parastagonospora nodorum 2,3-dimethoxy-5-(naphthalen-2-ylcarbonyl)pyridin-4(1H)-one
0.0267
-
-
 Parastagonospora nodorum 5-[(4-chlorophenyl)carbonyl]-2,3-dimethoxypyridin-4(1H)-one
0.03
-
 value above Bos taurus 2,3-dimethoxy-5-(2-methylbutanoyl)pyridin-4(1H)-one
0.03
-
 value above Parastagonospora nodorum 2,3-dimethoxy-5-(2-methylbutanoyl)pyridin-4(1H)-one
0.03
-
 value above Bos taurus 5-[(2-chlorophenyl)carbonyl]-2,3-dimethoxypyridin-4(1H)-one
0.03
-
 value above Parastagonospora nodorum 5-[(2-chlorophenyl)carbonyl]-2,3-dimethoxypyridin-4(1H)-one
0.03
-
 value above Bos taurus 2,3-dimethoxy-5-[(2-phenoxyphenyl)carbonyl]pyridin-4(1H)-one
0.03
-
 value above Parastagonospora nodorum 2,3-dimethoxy-5-[(2-phenoxyphenyl)carbonyl]pyridin-4(1H)-one
0.03
-
 value above Parastagonospora nodorum 5-[(3-chlorophenyl)carbonyl]-2,3-dimethoxypyridin-4(1H)-one
0.03
-
 value above Bos taurus 2,3-dimethoxy-5-[(4-methoxyphenyl)carbonyl]pyridin-4(1H)-one
0.03
-
 value above Parastagonospora nodorum 2,3-dimethoxy-5-[(4-methoxyphenyl)carbonyl]pyridin-4(1H)-one
0.03
-
 value above Parastagonospora nodorum (4-chlorophenyl)(2,4-dihydroxy-5,6-dimethoxypyridin-3-yl)methanone
0.03
-
 value above Parastagonospora nodorum 1-(2,4-dihydroxy-5,6-dimethoxypyridin-3-yl)-2,2-diphenylethanone
0.03
-
 value above Bos taurus 3-[(4-chlorophenyl)carbonyl]-2,5,6-trimethoxypyridin-4(1H)-one
0.03
-
 value above Parastagonospora nodorum 3-[(4-chlorophenyl)carbonyl]-2,5,6-trimethoxypyridin-4(1H)-one
0.03
-
 value above Bos taurus 3-[(4-chlorophenyl)carbonyl]-5,6-dimethoxypyridine-2,4-diyl diacetate
0.03
-
 value above Parastagonospora nodorum 3-[(4-chlorophenyl)carbonyl]-5,6-dimethoxypyridine-2,4-diyl diacetate
0.03
-
 value above Bos taurus 3-[(4-chlorophenyl)carbonyl]-5,6-dimethoxypyridine-2,4-diyl dimethanesulfonate
0.03
-
 value above Parastagonospora nodorum 3-[(4-chlorophenyl)carbonyl]-5,6-dimethoxypyridine-2,4-diyl dimethanesulfonate