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Literature summary for 1.3.5.1 extracted from

  • Neuzil, J.; Dyason, J.C.; Freeman, R.; Dong, L.F.; Prochazka, L.; Wang, X.F.; Scheffler, I.; Ralph, S.J.
    Mitocans as anti-cancer agents targeting mitochondria: lessons from studies with vitamin E analogues, inhibitors of complex II (2007), J. Bioenerg. Biomembr., 39, 65-72.
    View publication on PubMed
Search for more literature for 1.3.5.1

Inhibitors

Inhibitors Comment Organism Structure
alpha-tocopheryl succinate binds to the Qp site of the mitochondrial complex II causing the generation of superoxide triggering mitochondrial destabilisation and initiation of apoptotic pathways, mechanism, overview Bos taurus
vitamin E analogues epitomised by alpha-tocopheryl succinate affect the electron flow from complex II Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial membrane
-
 Bos taurus 31966
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Bos taurus vitamin E analogues bind to the Qp site of the mitochondrial complex II causing the generation of superoxide triggering mitochondrial destabilisation and initiation of apoptotic pathways, mechanism, overview ?
-
 ?
succinate + ubiquinone Bos taurus complex II is the only membrane bound enzyme of the Krebs cycle, and it feeds electrons into the electron transport chain from the oxidation of succinate fumarate + ubiquinol
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information vitamin E analogues bind to the Qp site of the mitochondrial complex II causing the generation of superoxide triggering mitochondrial destabilisation and initiation of apoptotic pathways, mechanism, overview Bos taurus ?
-
 ?
succinate + ubiquinone complex II is the only membrane bound enzyme of the Krebs cycle, and it feeds electrons into the electron transport chain from the oxidation of succinate Bos taurus fumarate + ubiquinol
-
 ?
succinate + ubiquinone electrons move from the FAD prosthetic group in SDH on to the two matrix subunits via a series of [Fe-S] redox clusters and possibly also via a heme group to end up at the terminal acceptor ubiquinone residing within the membrane subunits CybL and CybS Bos taurus fumarate + ubiquinol
-
 ?

Synonyms

Synonyms Comment Organism
mitochondrial complex II
-
 Bos taurus

Cofactor

Cofactor Comment Organism Structure
ubiquinone
-
 Bos taurus