Literature summary for 1.3.5.1 extracted from

Grivennikova, V.G.; Gavrikova, E.V.; Timoshin, A.A.; Vinogradov, A.D.
Fumarate reductase activity of bovine heart succinate-ubiquinone reductase. New assay system and overall properties of the reaction (1993), Biochim. Biophys. Acta, 1140, 282-292.

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Inhibitors

Inhibitors	Comment	Organism	Structure
4-Chloromercuriphenyl sulfonate	inhibitor of the succinate-ubiquinone reductase reaction	Bos taurus
carboxin	15% inhibition of the succinate-ubiquinone reductase and of the quinol-fumarate reductase reaction, competitive inhibition with quinone or quinol	Bos taurus
oxaloacetate	at 0.0006 mM: 20% inhibition of the succinate-ubiquinone reductase reaction and no inhibition of the fumarate reductase reaction, at 0.006 mM: 80% inhibition of fumarate reductase reaction	Bos taurus

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.025	-	fumarate	fumarate reduction, Km of fumarate does not depend on concentration of quinol	Bos taurus
0.03	-	succinate	fumarate reduction	Bos taurus
0.13	-	succinate	succinate oxidation, determined at 0.01 mM ubiquinone-2	Bos taurus
0.15	-	fumarate	succinate oxidation	Bos taurus

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	fumarate reductase	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
heart	-	Bos taurus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
succinate + ubiquinone	-	Bos taurus	fumarate + ubiquinol	-	r

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.002	-	carboxin	succinate oxidation	Bos taurus
0.003	-	carboxin	fumarate reduction	Bos taurus

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Release 2023.1 (January 2023)