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Literature summary for 1.3.3.4 extracted from

  • Birchfield, N.B.; Latli, B.; Casida, J.E.
    Human protoporphyrinogen oxidase: Relation between the herbicide binding site and the flavin cofactor (1998), Biochemistry, 37, 6905-6910.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
in Escherichia coli Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
acifluorfen competitive Homo sapiens
diphenylene iodonium 50% inhibition at 0.1 mM Homo sapiens
additional information inhibited by diphenylether herbicides; inhibited by tetrahydrophtalimide Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
protoporphyrinogen-IX + 3 O2 Homo sapiens penultimate step of heme and chlorophyll biosynthesis protoporphyrin-IX + 3 H2O2
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
cloned enzyme Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
protoporphyrinogen-IX + 3 O2
-
Homo sapiens protoporphyrin-IX + 3 H2O2
-
?
protoporphyrinogen-IX + 3 O2 penultimate step of heme and chlorophyll biosynthesis Homo sapiens protoporphyrin-IX + 3 H2O2
-
?

Cofactor

Cofactor Comment Organism Structure
FAD one noncovalently bound FAD per dimer Homo sapiens