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Literature summary for 1.3.3.4 extracted from
- Mouse protoporphyrinogen oxidase. Kinetic parameters and demonstration of inhibition by bilirubin (1988), Biochem. J., 250, 597-603.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| dicoumarol | below 0.015 mM | Mus musculus |  |
| Ubiquinone-10 | below 0.015 mM | Mus musculus | |
| ubiquinone-6 | below 0.015 mM | Mus musculus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| bilirubin | competitive | Mus musculus | |
| coenzyme Q0 | above 0.03 mM | Mus musculus | |
| dicoumarol | above 0.03 mM | Mus musculus | |
| menadione | above 0.03 mM | Mus musculus | |
| Ubiquinone-10 | above 0.03 mM | Mus musculus | |
| ubiquinone-6 | above 0.03 mM | Mus musculus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0066 | - |
protoporphyrinogen-IX | - |
Mus musculus | |
| 0.125 | - |
O2 | - |
Mus musculus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | lipid bilayer of inner membrane | Mus musculus | 5739 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| protoporphyrinogen-IX + 3 O2 | Mus musculus | penultimate step of heme and chlorophyll biosynthesis | protoporphyrin-IX + 3 H2O2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| protoporphyrinogen-IX + 3 O2 | - |
Mus musculus | protoporphyrin-IX + 3 H2O2 | - |
? | |
| protoporphyrinogen-IX + 3 O2 | penultimate step of heme and chlorophyll biosynthesis | Mus musculus | protoporphyrin-IX + 3 H2O2 | - |
? | |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.124 | - |
protoporphyrinogen-IX | - |
Mus musculus | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.025 | - |
bilirubin | - |
Mus musculus | |
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