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Literature summary for 1.3.3.3 extracted from

  • Lash, T.D.; Lamm, T.R.; Schaber, J.A.; Chung, W.H.; Johnson, E.K.; Jones, M.A.
    Normal and abnormal heme biosynthesis. Part 7. Synthesis and metabolism of coproporphyrinogen-III analogues with acetate or butyrate side chains on rings C and D. Development of a modified model for the active site of coproporphyrinogen oxidase (2011), Bioorg. Med. Chem., 19, 1492-1504.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Gallus gallus 5739
-
mitochondrion
-
Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
coproporphyrinogen III + O2 + 2 H+ Gallus gallus
-
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
?
coproporphyrinogen III + O2 + 2 H+ Homo sapiens
-
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
?

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
separation of uroporphyrinogen decarboxylase, EC 4.1.1.37, from coproporphyrinogen oxidase using porphyrin-affinity chromatography Gallus gallus

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
Gallus gallus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4,4'-[7,12-bis(2-carboxyethyl)-3,8,13,17-tetramethyl-5,10,15,20,22,24-hexahydroporphyrin-2,18-diyl]dibutanoic acid + O2 + 2 H+
-
Gallus gallus ? + 2 CO2 + 2 H2O major product is a monovinylporphyrinogen, but some divinyl product is also generated. The incubation products are converted into the corresponding porphyrin methyl esters, and characterized by proton NMR spectroscopy and mass spectrometry ?
4,4'-[7,12-bis(2-carboxyethyl)-3,8,13,17-tetramethyl-5,10,15,20,22,24-hexahydroporphyrin-2,18-diyl]dibutanoic acid + O2 + 2 H+
-
Homo sapiens ? + 2 CO2 + 2 H2O major product is a monovinylporphyrinogen, but some divinyl products are also generated. The incubation products are converted into the corresponding porphyrin methyl esters, and characterized by proton NMR spectroscopy and mass spectrometry ?
coproporphyrinogen III + O2 + 2 H+
-
Gallus gallus protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
?
coproporphyrinogen III + O2 + 2 H+
-
Homo sapiens protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
?
additional information porphyrinogen 3,3'-[13,17-bis(carboxymethyl)-3,8,12,18-tetramethyl-5,10,15,20,22,24-hexahydroporphyrin-2,7-diyl]dipropanoic acid proves to be a relatively poor substrate for CPO compared to the natural substrate coproporphyrinogen-III, and only the A ring propionate moiety is processed to a significant extent Gallus gallus ?
-
?
additional information porphyrinogen 3,3'-[13,17-bis(carboxymethyl)-3,8,12,18-tetramethyl-5,10,15,20,22,24-hexahydroporphyrin-2,7-diyl]dipropanoic acid proves to be a relatively poor substrate for CPO compared to the natural substrate coproporphyrinogen-III, and only the A ring propionate moiety is processed to a significant extent. Substrate recognition and catalysis, overview Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
CPO
-
Gallus gallus
CPO
-
Homo sapiens

General Information

General Information Comment Organism
metabolism separation of uroporphyrinogen decarboxylase, URO-D, EC 4.1.1.37, associated with the cytoplasm, and coproporphyrinogen oxidase, CPO, found in the mitochondria. They show in vitro competitive action of both on the same diacetate porphyrinogen substrate provides additional perspectives on the potential existence of abnormal pathways for heme biosynthesis. Porphyrinogen 3,3'-[13,17-bis(carboxymethyl)-3,8,12,18-tetramethyl-5,10,15,20,22,24-hexahydroporphyrin-2,7-diyl]dipropanoic acid is a reasonable substrate for URO-D but appears to be a comparatively poor substrate for CPO Homo sapiens