Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Gallus gallus | 5739 | - |
mitochondrion | - |
Homo sapiens | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
coproporphyrinogen III + O2 + 2 H+ | Gallus gallus | - |
protoporphyrinogen-IX + 2 CO2 + 2 H2O | - |
? | |
coproporphyrinogen III + O2 + 2 H+ | Homo sapiens | - |
protoporphyrinogen-IX + 2 CO2 + 2 H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Gallus gallus | - |
- |
- |
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
separation of uroporphyrinogen decarboxylase, EC 4.1.1.37, from coproporphyrinogen oxidase using porphyrin-affinity chromatography | Gallus gallus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythrocyte | - |
Gallus gallus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4,4'-[7,12-bis(2-carboxyethyl)-3,8,13,17-tetramethyl-5,10,15,20,22,24-hexahydroporphyrin-2,18-diyl]dibutanoic acid + O2 + 2 H+ | - |
Gallus gallus | ? + 2 CO2 + 2 H2O | major product is a monovinylporphyrinogen, but some divinyl product is also generated. The incubation products are converted into the corresponding porphyrin methyl esters, and characterized by proton NMR spectroscopy and mass spectrometry | ? | |
4,4'-[7,12-bis(2-carboxyethyl)-3,8,13,17-tetramethyl-5,10,15,20,22,24-hexahydroporphyrin-2,18-diyl]dibutanoic acid + O2 + 2 H+ | - |
Homo sapiens | ? + 2 CO2 + 2 H2O | major product is a monovinylporphyrinogen, but some divinyl products are also generated. The incubation products are converted into the corresponding porphyrin methyl esters, and characterized by proton NMR spectroscopy and mass spectrometry | ? | |
coproporphyrinogen III + O2 + 2 H+ | - |
Gallus gallus | protoporphyrinogen-IX + 2 CO2 + 2 H2O | - |
? | |
coproporphyrinogen III + O2 + 2 H+ | - |
Homo sapiens | protoporphyrinogen-IX + 2 CO2 + 2 H2O | - |
? | |
additional information | porphyrinogen 3,3'-[13,17-bis(carboxymethyl)-3,8,12,18-tetramethyl-5,10,15,20,22,24-hexahydroporphyrin-2,7-diyl]dipropanoic acid proves to be a relatively poor substrate for CPO compared to the natural substrate coproporphyrinogen-III, and only the A ring propionate moiety is processed to a significant extent | Gallus gallus | ? | - |
? | |
additional information | porphyrinogen 3,3'-[13,17-bis(carboxymethyl)-3,8,12,18-tetramethyl-5,10,15,20,22,24-hexahydroporphyrin-2,7-diyl]dipropanoic acid proves to be a relatively poor substrate for CPO compared to the natural substrate coproporphyrinogen-III, and only the A ring propionate moiety is processed to a significant extent. Substrate recognition and catalysis, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CPO | - |
Gallus gallus |
CPO | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | separation of uroporphyrinogen decarboxylase, URO-D, EC 4.1.1.37, associated with the cytoplasm, and coproporphyrinogen oxidase, CPO, found in the mitochondria. They show in vitro competitive action of both on the same diacetate porphyrinogen substrate provides additional perspectives on the potential existence of abnormal pathways for heme biosynthesis. Porphyrinogen 3,3'-[13,17-bis(carboxymethyl)-3,8,12,18-tetramethyl-5,10,15,20,22,24-hexahydroporphyrin-2,7-diyl]dipropanoic acid is a reasonable substrate for URO-D but appears to be a comparatively poor substrate for CPO | Homo sapiens |