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Literature summary for 1.3.3.3 extracted from

  • Nagaraj, V.A.; Prasad, D.; Arumugam, R.; Rangarajan, P.N.; Padmanaban, G.
    Characterization of coproporphyrinogen III oxidase in Plasmodium falciparum cytosol (2010), Parasitol. Int., 59, 121-127.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
functional expression in Escherichia coli Plasmodium falciparum
recombinant expression of His-tagged enzyme in Escherichia coli Plasmodium falciparum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00967
-
Coproporphyrinogen III pH 7.5, 37°C, recombinant enzyme Plasmodium falciparum
0.0151
-
Coproporphyrinogen III pH 7.5, 37°C, native enzyme Plasmodium falciparum

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Plasmodium falciparum 5829
-
cytosol exclusively Plasmodium falciparum 5829
-
additional information no localization in the mitochondrion Plasmodium falciparum
-
-
additional information PfCPO does not carry an obvious N-terminal leader targeting sequence, subcellular localization study, overview. No measurable activity in the solubilized parasite membrane fraction Plasmodium falciparum
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
additional information metal ions Cu2+, Mg2+, Mn2+, Fe2+ and Zn2+ at up to 0.500 mM concentration have no effect on CPO activity Plasmodium falciparum

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
58000
-
1 * 58000, recombinant enzyme, SDS-PAGE Plasmodium falciparum
61000
-
recombinant enzyme, gel filtration Plasmodium falciparum
61000
-
recombiinant enzyme, gel filtration Plasmodium falciparum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
coproporphyrinogen III + O2 + 2 H+ Plasmodium falciparum
-
protoporphyrinogen IX + 2 CO2 + 2 H2O
-
?
coproporphyrinogen III + O2 + 2 H+ Plasmodium falciparum
-
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
?

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant His-tagged enzyme from Escherichia coli, cleavage of the tag Plasmodium falciparum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
coproporphyrinogen III + O2 + 2 H+
-
Plasmodium falciparum protoporphyrinogen IX + 2 CO2 + 2 H2O
-
?
coproporphyrinogen III + O2 + 2 H+
-
Plasmodium falciparum protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
?
additional information no activity with S-adenosylmethionine or without O2 Plasmodium falciparum ?
-
?

Subunits

Subunits Comment Organism
monomer 1 * 58000, recombinant enzyme, SDS-PAGE Plasmodium falciparum
More sequence comparisons, overview Plasmodium falciparum

Synonyms

Synonyms Comment Organism
coproporphyrinogen III oxidase
-
Plasmodium falciparum
CPO
-
Plasmodium falciparum

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
-
Plasmodium falciparum
37
-
recombinant enzyme Plasmodium falciparum

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
25 50 activity range, recombinant enzyme Plasmodium falciparum

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
-
Plasmodium falciparum
7.6
-
recombinant enzyme Plasmodium falciparum

pH Range

pH Minimum pH Maximum Comment Organism
6 9 activity range, recombinant enzyme Plasmodium falciparum