Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Phospholipids | effective in decreasing the amount of intermediate accumulation, oxidation of 2,4-bis(beta-hydroxypropionic acid) deuteroporphyrinogen IX not activated | Bos taurus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Tetranitromethane | 60% decrease of Vmax at 1.6 mol modified tyrosine per mol enzyme, Km not affected | Bos taurus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.039 | - |
Harderoporphyrinogen | presence of L-alpha-phosphatidylethanolamine | Bos taurus | |
0.044 | - |
Harderoporphyrinogen | - |
Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
coproporphyrinogen-III + O2 + 2 H+ | Bos taurus | - |
protoporphyrinogen-IX + 2 CO2 + 2 H2O | - |
? | |
harderoporphyrinogen + O2 | Bos taurus | 30% higher activity compared to coproporphyrinogen-III | protoporphyrinogen IX + CO2 + H2O2 | - |
? | |
isoharderoporphyrinogen + O2 | Bos taurus | 3% of the activity compared to coproporphyrinogen-III | protoporphyrinogen IX + CO2 + H2O2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2,4-bis-(beta-hydroxypropionic acid) deuteroporphyrinogen IX + O2 | one sixth of the rate compared to coproporhyrinogen-III | Bos taurus | protoporphyrinogen IX + CO2 | - |
? | |
2-beta-hydroxypropionic acid-4-propionic acid deuteroporphyrinogen IX + O2 | 80% of the activity compared to coproporphyrinogen-III | Bos taurus | protoporphyrinogen IX + CO2 | - |
? | |
2-propionic acid-4-beta-hydroxypropionic acid deuteroporphyrinogen IX + O2 | 8% of the activity compared to coproporphyrinogen-III | Bos taurus | protoporphyrinogen IX + CO2 | - |
? | |
coproporphyrinogen-III + O2 + 2 H+ | - |
Bos taurus | protoporphyrinogen-IX + 2 CO2 + 2 H2O | - |
? | |
harderoporphyrinogen + O2 | 30% higher activity compared to coproporphyrinogen-III | Bos taurus | protoporphyrinogen IX + CO2 + H2O2 | - |
? | |
isoharderoporphyrinogen + O2 | 3% of the activity compared to coproporphyrinogen-III | Bos taurus | protoporphyrinogen IX + CO2 + H2O2 | - |
? |