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Literature summary for 1.3.3.3 extracted from

  • Yoshinaga, T.; Sano, S.
    Coproporphyrinogen oxidase. II. Reaction mechanism and role of tyrosine residues on the activity (1980), J. Biol. Chem., 255, 4727-4731.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Phospholipids effective in decreasing the amount of intermediate accumulation, oxidation of 2,4-bis(beta-hydroxypropionic acid) deuteroporphyrinogen IX not activated Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
Tetranitromethane 60% decrease of Vmax at 1.6 mol modified tyrosine per mol enzyme, Km not affected Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.039
-
Harderoporphyrinogen presence of L-alpha-phosphatidylethanolamine Bos taurus
0.044
-
Harderoporphyrinogen
-
Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
coproporphyrinogen-III + O2 + 2 H+ Bos taurus
-
protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
?
harderoporphyrinogen + O2 Bos taurus 30% higher activity compared to coproporphyrinogen-III protoporphyrinogen IX + CO2 + H2O2
-
?
isoharderoporphyrinogen + O2 Bos taurus 3% of the activity compared to coproporphyrinogen-III protoporphyrinogen IX + CO2 + H2O2
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2,4-bis-(beta-hydroxypropionic acid) deuteroporphyrinogen IX + O2 one sixth of the rate compared to coproporhyrinogen-III Bos taurus protoporphyrinogen IX + CO2
-
?
2-beta-hydroxypropionic acid-4-propionic acid deuteroporphyrinogen IX + O2 80% of the activity compared to coproporphyrinogen-III Bos taurus protoporphyrinogen IX + CO2
-
?
2-propionic acid-4-beta-hydroxypropionic acid deuteroporphyrinogen IX + O2 8% of the activity compared to coproporphyrinogen-III Bos taurus protoporphyrinogen IX + CO2
-
?
coproporphyrinogen-III + O2 + 2 H+
-
Bos taurus protoporphyrinogen-IX + 2 CO2 + 2 H2O
-
?
harderoporphyrinogen + O2 30% higher activity compared to coproporphyrinogen-III Bos taurus protoporphyrinogen IX + CO2 + H2O2
-
?
isoharderoporphyrinogen + O2 3% of the activity compared to coproporphyrinogen-III Bos taurus protoporphyrinogen IX + CO2 + H2O2
-
?