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Literature summary for 1.3.1.B14 extracted from

  • Khare, D.; Hale, W.; Tripathi, A.; Gu, L.; Sherman, D.; Gerwick, W.; Hakansson, K.; Smith, J.
    Structural basis for cyclopropanation by a unique enoyl-acyl carrier protein reductase (2015), Structure, 23, 2213-2223 .
    View publication on PubMed
Search for more literature for 1.3.1.B14

Cloned(Commentary)

Cloned (Comment) Organism
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 Lyngbya majuscula

Crystallization (Commentary)

Crystallization (Comment) Organism
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 Lyngbya majuscula

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(2E,4E,6E,10Z)-4-methyl-11-[2-[(1R,2S)-2-methylcyclopropyl]-4,5-dihydro-1,3-thiazol-4-yl]undeca-2,4,6,10-tetraenoyl-[acyl-carrier-protein] + NADPH + H+ Lyngbya majuscula
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 (2E,4E,6E,10Z)-4-methyl-11-[2-[(1R,2S)-2-methylcyclopropyl]-4,5-dihydro-1,3-thiazol-4-yl]undeca-4,6,10-trienoyl-[acyl-carrier-protein] + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Lyngbya majuscula Q6DNE2
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(2E,4E,6E,10Z)-4-methyl-11-[2-[(1R,2S)-2-methylcyclopropyl]-4,5-dihydro-1,3-thiazol-4-yl]undeca-2,4,6,10-tetraenoyl-[acyl-carrier-protein] + NADPH + H+
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 Lyngbya majuscula (2E,4E,6E,10Z)-4-methyl-11-[2-[(1R,2S)-2-methylcyclopropyl]-4,5-dihydro-1,3-thiazol-4-yl]undeca-4,6,10-trienoyl-[acyl-carrier-protein] + NADP+
-
 ?
crotonyl-CoA + NADPH + H+
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 Lyngbya majuscula butanoyl-CoA + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
curacin enoyl reductase
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 Lyngbya majuscula
CurK
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 Lyngbya majuscula

Cofactor

Cofactor Comment Organism Structure
NADPH loops that contact NADPH show flexibility Lyngbya majuscula

General Information

General Information Comment Organism
physiological function enzyme is involved in biosynthesis of anticancer agent curacin A Lyngbya majuscula