BRENDA - Enzyme Database
show all sequences of 1.3.1.9

Virtually designed triclosan-based inhibitors of enoyl-acyl carrier protein reductase of Mycobacterium tuberculosis and of Plasmodium falciparum

Owono Owono, L.C.; Ntie-Kang, F.; Keita, M.; Megnassan, E.; Frecer, V.; Miertus, S.; Mol. Inform. 34, 292-307 (2015)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
2-(2,4-dichlorophenoxy)-5-(2-methylbutyl)phenol
-
Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-(2-methylbutyl)phenol
-
Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-(2-methylpropyl)phenol
-
Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-(2-methylpropyl)phenol
-
Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-(2-phenylethyl)phenol
-
Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-(2-phenylethyl)phenol
-
Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-(3-methylbutyl)phenol
-
Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-(3-methylbutyl)phenol
-
Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-(3-phenylpropyl)phenol
-
Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-(3-phenylpropyl)phenol
-
Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-(4-phenylbutyl)phenol
-
Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-(4-phenylbutyl)phenol
-
Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-ethylphenol
-
Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-ethylphenol
-
Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-methylphenol
-
Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-methylphenol
-
Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-propylphenol
-
Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-propylphenol
-
Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-[(2-methylphenyl)methyl]phenol
-
Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-[(2-methylphenyl)methyl]phenol
-
Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-[(3-methylphenyl)methyl]phenol
-
Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-[(3-methylphenyl)methyl]phenol
-
Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-[(4-fluorophenyl)methyl]phenol
-
Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-[(4-fluorophenyl)methyl]phenol
-
Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-[(pyridin-2-yl)methyl]phenol
-
Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-[(pyridin-2-yl)methyl]phenol
-
Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-[(pyridin-3-yl)methyl]phenol
-
Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-[(pyridin-3-yl)methyl]phenol
-
Plasmodium falciparum
2-[2-(dimethylamino)-4-sulfanylphenoxy]-5-{[(2-phenylethyl)amino]methyl}phenol
-
Mycobacterium tuberculosis
2-[2-(dimethylamino)-4-sulfanylphenoxy]-5-{[(2-phenylethyl)amino]methyl}phenol
-
Plasmodium falciparum
2-[4-({[(2,3-dihydro-1-benzofuran-6-yl)methyl]amino}methyl)-2-hydroxyphenoxy]-5-methylbenzonitrile
-
Mycobacterium tuberculosis
2-[4-({[(2,3-dihydro-1-benzofuran-6-yl)methyl]amino}methyl)-2-hydroxyphenoxy]-5-methylbenzonitrile
-
Plasmodium falciparum
3'-methyl-4-[2-(methylamino)-4-(3-methylbutyl)phenoxy][1,1'-biphenyl]-3-ol
-
Mycobacterium tuberculosis
3'-methyl-4-[2-(methylamino)-4-(3-methylbutyl)phenoxy][1,1'-biphenyl]-3-ol
-
Plasmodium falciparum
3'-methyl-4-[2-(methylamino)-4-(propan-2-yl)phenoxy][1,1'-biphenyl]-3-ol
-
Mycobacterium tuberculosis
3'-methyl-4-[2-(methylamino)-4-(propan-2-yl)phenoxy][1,1'-biphenyl]-3-ol
-
Plasmodium falciparum
3'-methyl-4-{[3-(methylamino)[1,1'-biphenyl]-4-yl]oxy}[1,1'-biphenyl]-3-ol
-
Mycobacterium tuberculosis
3'-methyl-4-{[3-(methylamino)[1,1'-biphenyl]-4-yl]oxy}[1,1'-biphenyl]-3-ol
-
Plasmodium falciparum
3-chloro-4-[2-hydroxy-4-[(2-methylphenyl)methyl]phenoxy]benzonitrile
-
Mycobacterium tuberculosis
3-chloro-4-[2-hydroxy-4-[(2-methylphenyl)methyl]phenoxy]benzonitrile
-
Plasmodium falciparum
3-chloro-4-[2-hydroxy-4-[(pyridin-4-yl)methyl]phenoxy]benzonitrile
-
Mycobacterium tuberculosis
3-chloro-4-[2-hydroxy-4-[(pyridin-4-yl)methyl]phenoxy]benzonitrile
-
Plasmodium falciparum
4-[(3-ethyl[1,1'-biphenyl]-4-yl)oxy]-3'-methyl[1,1'-biphenyl]-3-ol
-
Mycobacterium tuberculosis
4-[(3-ethyl[1,1'-biphenyl]-4-yl)oxy]-3'-methyl[1,1'-biphenyl]-3-ol
-
Plasmodium falciparum
4-[2-(dimethylamino)-4-(3-methylbutyl)phenoxy]-3'-methyl[1,1'-biphenyl]-3-ol
-
Mycobacterium tuberculosis
4-[2-(dimethylamino)-4-(3-methylbutyl)phenoxy]-3'-methyl[1,1'-biphenyl]-3-ol
-
Plasmodium falciparum
4-[2-(dimethylamino)-4-(propan-2-yl)phenoxy]-3'-methyl[1,1'-biphenyl]-3-ol
-
Mycobacterium tuberculosis
4-[2-(dimethylamino)-4-(propan-2-yl)phenoxy]-3'-methyl[1,1'-biphenyl]-3-ol
-
Plasmodium falciparum
4-[2-ethyl-4-(3-methylbutyl)phenoxy]-3'-methyl[1,1'-biphenyl]-3-ol
-
Mycobacterium tuberculosis
4-[2-ethyl-4-(3-methylbutyl)phenoxy]-3'-methyl[1,1'-biphenyl]-3-ol
-
Plasmodium falciparum
4-[2-ethyl-4-(propan-2-yl)phenoxy]-3'-methyl[1,1'-biphenyl]-3-ol
-
Mycobacterium tuberculosis
4-[2-ethyl-4-(propan-2-yl)phenoxy]-3'-methyl[1,1'-biphenyl]-3-ol
-
Plasmodium falciparum
4-[4-({[2-(4-chlorophenyl)ethyl]amino}methyl)-2-hydroxyphenoxy]-3-(methylamino)anilinium
-
Mycobacterium tuberculosis
4-[4-({[2-(4-chlorophenyl)ethyl]amino}methyl)-2-hydroxyphenoxy]-3-(methylamino)anilinium
-
Plasmodium falciparum
4-{4-[(benzylamino)methyl]-2-hydroxyphenoxy}-3-chlorobenzonitrile
-
Mycobacterium tuberculosis
4-{4-[(benzylamino)methyl]-2-hydroxyphenoxy}-3-chlorobenzonitrile
-
Plasmodium falciparum
4-{[3-(dimethylamino)[1,1'-biphenyl]-4-yl]oxy}-3'-methyl[1,1'-biphenyl]-3-ol
-
Mycobacterium tuberculosis
4-{[3-(dimethylamino)[1,1'-biphenyl]-4-yl]oxy}-3'-methyl[1,1'-biphenyl]-3-ol
-
Plasmodium falciparum
5-(anilinomethyl)-2-[(3-ethyl[1,1'-biphenyl]-4-yl)oxy]phenol
-
Mycobacterium tuberculosis
5-(anilinomethyl)-2-[(3-ethyl[1,1'-biphenyl]-4-yl)oxy]phenol
-
Plasmodium falciparum
5-(anilinomethyl)-2-[2-(dimethylamino)-4-(3-methylbutyl)phenoxy]phenol
-
Mycobacterium tuberculosis
5-(anilinomethyl)-2-[2-(dimethylamino)-4-(3-methylbutyl)phenoxy]phenol
-
Plasmodium falciparum
5-(anilinomethyl)-2-[2-(dimethylamino)-4-(propan-2-yl)phenoxy]phenol
-
Mycobacterium tuberculosis
5-(anilinomethyl)-2-[2-(dimethylamino)-4-(propan-2-yl)phenoxy]phenol
-
Plasmodium falciparum
5-(anilinomethyl)-2-[2-(methylamino)-4-(3-methylbutyl)phenoxy]phenol
-
Mycobacterium tuberculosis
5-(anilinomethyl)-2-[2-(methylamino)-4-(3-methylbutyl)phenoxy]phenol
-
Plasmodium falciparum
5-(anilinomethyl)-2-[2-(methylamino)-4-(propan-2-yl)phenoxy]phenol
-
Mycobacterium tuberculosis
5-(anilinomethyl)-2-[2-(methylamino)-4-(propan-2-yl)phenoxy]phenol
-
Plasmodium falciparum
5-(anilinomethyl)-2-[2-ethyl-4-(3-methylbutyl)phenoxy]phenol
-
Mycobacterium tuberculosis
5-(anilinomethyl)-2-[2-ethyl-4-(3-methylbutyl)phenoxy]phenol
-
Plasmodium falciparum
5-(anilinomethyl)-2-[2-ethyl-4-(propan-2-yl)phenoxy]phenol
-
Mycobacterium tuberculosis
5-(anilinomethyl)-2-[2-ethyl-4-(propan-2-yl)phenoxy]phenol
-
Plasmodium falciparum
5-(anilinomethyl)-2-{[3-(dimethylamino)[1,1'-biphenyl]-4-yl]oxy}phenol
-
Mycobacterium tuberculosis
5-(anilinomethyl)-2-{[3-(dimethylamino)[1,1'-biphenyl]-4-yl]oxy}phenol
-
Plasmodium falciparum
5-(anilinomethyl)-2-{[3-(methylamino)[1,1'-biphenyl]-4-yl]oxy}phenol
-
Mycobacterium tuberculosis
5-(anilinomethyl)-2-{[3-(methylamino)[1,1'-biphenyl]-4-yl]oxy}phenol
-
Plasmodium falciparum
5-(cyclohexylmethyl)-2-(2,4-dichlorophenoxy)phenol
-
Mycobacterium tuberculosis
5-(cyclohexylmethyl)-2-(2,4-dichlorophenoxy)phenol
-
Plasmodium falciparum
5-(cyclohexylmethyl)-2-[(3-ethyl[1,1'-biphenyl]-4-yl)oxy]phenol
-
Mycobacterium tuberculosis
5-(cyclohexylmethyl)-2-[(3-ethyl[1,1'-biphenyl]-4-yl)oxy]phenol
-
Plasmodium falciparum
5-(cyclohexylmethyl)-2-[2-(dimethylamino)-4-(3-methylbutyl)phenoxy]phenol
-
Mycobacterium tuberculosis
5-(cyclohexylmethyl)-2-[2-(dimethylamino)-4-(3-methylbutyl)phenoxy]phenol
-
Plasmodium falciparum
5-(cyclohexylmethyl)-2-[2-(dimethylamino)-4-(propan-2-yl)phenoxy]phenol
-
Mycobacterium tuberculosis
5-(cyclohexylmethyl)-2-[2-(dimethylamino)-4-(propan-2-yl)phenoxy]phenol
-
Plasmodium falciparum
5-(cyclohexylmethyl)-2-[2-(methylamino)-4-(3-methylbutyl)phenoxy]phenol
-
Mycobacterium tuberculosis
5-(cyclohexylmethyl)-2-[2-(methylamino)-4-(3-methylbutyl)phenoxy]phenol
-
Plasmodium falciparum
5-(cyclohexylmethyl)-2-[2-(methylamino)-4-(propan-2-yl)phenoxy]phenol
-
Mycobacterium tuberculosis
5-(cyclohexylmethyl)-2-[2-(methylamino)-4-(propan-2-yl)phenoxy]phenol
-
Plasmodium falciparum
5-(cyclohexylmethyl)-2-[2-ethyl-4-(3-methylbutyl)phenoxy]phenol
-
Mycobacterium tuberculosis
5-(cyclohexylmethyl)-2-[2-ethyl-4-(3-methylbutyl)phenoxy]phenol
-
Plasmodium falciparum
5-(cyclohexylmethyl)-2-[2-ethyl-4-(propan-2-yl)phenoxy]phenol
-
Mycobacterium tuberculosis
5-(cyclohexylmethyl)-2-[2-ethyl-4-(propan-2-yl)phenoxy]phenol
-
Plasmodium falciparum
5-(cyclohexylmethyl)-2-{[3-(dimethylamino)[1,1'-biphenyl]-4-yl]oxy}phenol
-
Mycobacterium tuberculosis
5-(cyclohexylmethyl)-2-{[3-(dimethylamino)[1,1'-biphenyl]-4-yl]oxy}phenol
-
Plasmodium falciparum
5-(cyclohexylmethyl)-2-{[3-(methylamino)[1,1'-biphenyl]-4-yl]oxy}phenol
-
Mycobacterium tuberculosis
5-(cyclohexylmethyl)-2-{[3-(methylamino)[1,1'-biphenyl]-4-yl]oxy}phenol
-
Plasmodium falciparum
5-({[(2,3-dihydro-1-benzofuran-6-yl)methyl]amino}methyl)-2-[2-methyl-4-(methylamino)phenoxy]phenol
-
Mycobacterium tuberculosis
5-({[(2,3-dihydro-1-benzofuran-6-yl)methyl]amino}methyl)-2-[2-methyl-4-(methylamino)phenoxy]phenol
-
Plasmodium falciparum
5-({[2-(4-chlorophenyl)ethyl]amino}methyl)-2-[2-(dimethylamino)-4-ethylphenoxy]phenol
-
Mycobacterium tuberculosis
5-({[2-(4-chlorophenyl)ethyl]amino}methyl)-2-[2-(dimethylamino)-4-ethylphenoxy]phenol
-
Plasmodium falciparum
5-({[2-(4-chlorophenyl)ethyl]amino}methyl)-2-[2-ethyl-4-(sulfanylmethyl)phenoxy]phenol
-
Mycobacterium tuberculosis
5-({[2-(4-chlorophenyl)ethyl]amino}methyl)-2-[2-ethyl-4-(sulfanylmethyl)phenoxy]phenol
-
Plasmodium falciparum
5-butyl-2-(2,4-dichlorophenoxy)phenol
-
Mycobacterium tuberculosis
5-butyl-2-(2,4-dichlorophenoxy)phenol
-
Plasmodium falciparum
5-chloro-2-(2,4-dichlorophenoxy)phenol
-
Mycobacterium tuberculosis
5-chloro-2-(2,4-dichlorophenoxy)phenol
-
Plasmodium falciparum
5-cyclohexyl-2-(2-hydrazinyl-4-propylphenoxy)phenol
-
Mycobacterium tuberculosis
5-cyclohexyl-2-(2-hydrazinyl-4-propylphenoxy)phenol
-
Plasmodium falciparum
5-[(benzylamino)methyl]-2-[2-(dimethylamino)-4-ethylphenoxy]phenol
-
Mycobacterium tuberculosis
5-[(benzylamino)methyl]-2-[2-(dimethylamino)-4-ethylphenoxy]phenol
-
Plasmodium falciparum
triclosan
-
Mycobacterium tuberculosis
triclosan
-
Plasmodium falciparum
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Mycobacterium tuberculosis
-
-
-
Plasmodium falciparum
-
-
-
IC50 Value
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
0.000021
-
pH and temperature not specified in the publication
Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-(3-phenylpropyl)phenol
0.000029
-
pH and temperature not specified in the publication
Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-[(pyridin-2-yl)methyl]phenol
0.000038
-
pH and temperature not specified in the publication
Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-[(4-fluorophenyl)methyl]phenol
0.000042
-
pH and temperature not specified in the publication
Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-[(pyridin-3-yl)methyl]phenol
0.00005
-
pH and temperature not specified in the publication
Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-(4-phenylbutyl)phenol
0.000051
-
pH and temperature not specified in the publication
Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-(2-phenylethyl)phenol
0.000055
-
pH and temperature not specified in the publication
Mycobacterium tuberculosis
5-butyl-2-(2,4-dichlorophenoxy)phenol
0.000063
-
pH and temperature not specified in the publication
Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-(3-methylbutyl)phenol
0.000071
-
pH and temperature not specified in the publication
Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-(2-phenylethyl)phenol
0.000073
-
pH and temperature not specified in the publication
Plasmodium falciparum
5-chloro-2-(2,4-dichlorophenoxy)phenol
0.000075
-
pH and temperature not specified in the publication
Mycobacterium tuberculosis
3-chloro-4-[2-hydroxy-4-[(pyridin-4-yl)methyl]phenoxy]benzonitrile
0.000076
-
pH and temperature not specified in the publication
Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-(3-phenylpropyl)phenol
0.000091
-
pH and temperature not specified in the publication
Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-propylphenol
0.000096
-
pH and temperature not specified in the publication
Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-(2-methylpropyl)phenol
0.00011
-
pH and temperature not specified in the publication
Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-ethylphenol
0.00011
-
pH and temperature not specified in the publication
Mycobacterium tuberculosis
5-(cyclohexylmethyl)-2-(2,4-dichlorophenoxy)phenol
0.00012
-
pH and temperature not specified in the publication
Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-(3-methylbutyl)phenol
0.00012
-
pH and temperature not specified in the publication
Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-ethylphenol
0.00013
-
pH and temperature not specified in the publication
Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-(2-methylbutyl)phenol
0.00018
-
pH and temperature not specified in the publication
Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-(2-methylpropyl)phenol
0.0002
-
pH and temperature not specified in the publication
Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-methylphenol
0.00021
-
pH and temperature not specified in the publication
Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-propylphenol
0.00023
-
pH and temperature not specified in the publication
Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-[(3-methylphenyl)methyl]phenol
0.00029
-
pH and temperature not specified in the publication
Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-(2-methylbutyl)phenol
0.00041
-
pH and temperature not specified in the publication
Plasmodium falciparum
3-chloro-4-[2-hydroxy-4-[(2-methylphenyl)methyl]phenoxy]benzonitrile
0.00044
-
pH and temperature not specified in the publication
Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-[(2-methylphenyl)methyl]phenol
0.00044
-
pH and temperature not specified in the publication
Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-(4-phenylbutyl)phenol
0.00048
-
pH and temperature not specified in the publication
Plasmodium falciparum
5-butyl-2-(2,4-dichlorophenoxy)phenol
0.00053
-
pH and temperature not specified in the publication
Plasmodium falciparum
3-chloro-4-[2-hydroxy-4-[(pyridin-4-yl)methyl]phenoxy]benzonitrile
0.00053
-
pH and temperature not specified in the publication
Plasmodium falciparum
5-(cyclohexylmethyl)-2-(2,4-dichlorophenoxy)phenol
0.00064
-
pH and temperature not specified in the publication
Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-[(pyridin-2-yl)methyl]phenol
0.0008
-
pH and temperature not specified in the publication
Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-methylphenol
0.00084
-
pH and temperature not specified in the publication
Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-[(pyridin-3-yl)methyl]phenol
0.00087
-
pH and temperature not specified in the publication
Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-[(3-methylphenyl)methyl]phenol
0.0011
-
pH and temperature not specified in the publication
Mycobacterium tuberculosis
5-chloro-2-(2,4-dichlorophenoxy)phenol
0.0013
-
pH and temperature not specified in the publication
Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-[(2-methylphenyl)methyl]phenol
0.01
-
pH and temperature not specified in the publication
Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-[(4-fluorophenyl)methyl]phenol
0.01
-
pH and temperature not specified in the publication
Mycobacterium tuberculosis
3-chloro-4-[2-hydroxy-4-[(2-methylphenyl)methyl]phenoxy]benzonitrile
IC50 Value (protein specific)
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
0.000021
-
pH and temperature not specified in the publication
Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-(3-phenylpropyl)phenol
0.000029
-
pH and temperature not specified in the publication
Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-[(pyridin-2-yl)methyl]phenol
0.000038
-
pH and temperature not specified in the publication
Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-[(4-fluorophenyl)methyl]phenol
0.000042
-
pH and temperature not specified in the publication
Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-[(pyridin-3-yl)methyl]phenol
0.00005
-
pH and temperature not specified in the publication
Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-(4-phenylbutyl)phenol
0.000051
-
pH and temperature not specified in the publication
Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-(2-phenylethyl)phenol
0.000055
-
pH and temperature not specified in the publication
Mycobacterium tuberculosis
5-butyl-2-(2,4-dichlorophenoxy)phenol
0.000063
-
pH and temperature not specified in the publication
Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-(3-methylbutyl)phenol
0.000071
-
pH and temperature not specified in the publication
Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-(2-phenylethyl)phenol
0.000073
-
pH and temperature not specified in the publication
Plasmodium falciparum
5-chloro-2-(2,4-dichlorophenoxy)phenol
0.000075
-
pH and temperature not specified in the publication
Mycobacterium tuberculosis
3-chloro-4-[2-hydroxy-4-[(pyridin-4-yl)methyl]phenoxy]benzonitrile
0.000076
-
pH and temperature not specified in the publication
Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-(3-phenylpropyl)phenol
0.000091
-
pH and temperature not specified in the publication
Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-propylphenol
0.000096
-
pH and temperature not specified in the publication
Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-(2-methylpropyl)phenol
0.00011
-
pH and temperature not specified in the publication
Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-ethylphenol
0.00011
-
pH and temperature not specified in the publication
Mycobacterium tuberculosis
5-(cyclohexylmethyl)-2-(2,4-dichlorophenoxy)phenol
0.00012
-
pH and temperature not specified in the publication
Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-(3-methylbutyl)phenol
0.00012
-
pH and temperature not specified in the publication
Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-ethylphenol
0.00013
-
pH and temperature not specified in the publication
Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-(2-methylbutyl)phenol
0.00018
-
pH and temperature not specified in the publication
Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-(2-methylpropyl)phenol
0.0002
-
pH and temperature not specified in the publication
Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-methylphenol
0.00021
-
pH and temperature not specified in the publication
Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-propylphenol
0.00023
-
pH and temperature not specified in the publication
Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-[(3-methylphenyl)methyl]phenol
0.00029
-
pH and temperature not specified in the publication
Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-(2-methylbutyl)phenol
0.00041
-
pH and temperature not specified in the publication
Plasmodium falciparum
3-chloro-4-[2-hydroxy-4-[(2-methylphenyl)methyl]phenoxy]benzonitrile
0.00044
-
pH and temperature not specified in the publication
Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-[(2-methylphenyl)methyl]phenol
0.00044
-
pH and temperature not specified in the publication
Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-(4-phenylbutyl)phenol
0.00048
-
pH and temperature not specified in the publication
Plasmodium falciparum
5-butyl-2-(2,4-dichlorophenoxy)phenol
0.00053
-
pH and temperature not specified in the publication
Plasmodium falciparum
3-chloro-4-[2-hydroxy-4-[(pyridin-4-yl)methyl]phenoxy]benzonitrile
0.00053
-
pH and temperature not specified in the publication
Plasmodium falciparum
5-(cyclohexylmethyl)-2-(2,4-dichlorophenoxy)phenol
0.00064
-
pH and temperature not specified in the publication
Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-[(pyridin-2-yl)methyl]phenol
0.0008
-
pH and temperature not specified in the publication
Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-methylphenol
0.00084
-
pH and temperature not specified in the publication
Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-[(pyridin-3-yl)methyl]phenol
0.00087
-
pH and temperature not specified in the publication
Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-[(3-methylphenyl)methyl]phenol
0.0011
-
pH and temperature not specified in the publication
Mycobacterium tuberculosis
5-chloro-2-(2,4-dichlorophenoxy)phenol
0.0013
-
pH and temperature not specified in the publication
Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-[(2-methylphenyl)methyl]phenol
0.01
-
pH and temperature not specified in the publication
Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-[(4-fluorophenyl)methyl]phenol
0.01
-
pH and temperature not specified in the publication
Mycobacterium tuberculosis
3-chloro-4-[2-hydroxy-4-[(2-methylphenyl)methyl]phenoxy]benzonitrile
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
2-(2,4-dichlorophenoxy)-5-(2-methylbutyl)phenol
-
Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-(2-methylbutyl)phenol
-
Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-(2-methylpropyl)phenol
-
Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-(2-methylpropyl)phenol
-
Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-(2-phenylethyl)phenol
-
Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-(2-phenylethyl)phenol
-
Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-(3-methylbutyl)phenol
-
Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-(3-methylbutyl)phenol
-
Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-(3-phenylpropyl)phenol
-
Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-(3-phenylpropyl)phenol
-
Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-(4-phenylbutyl)phenol
-
Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-(4-phenylbutyl)phenol
-
Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-ethylphenol
-
Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-ethylphenol
-
Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-methylphenol
-
Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-methylphenol
-
Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-propylphenol
-
Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-propylphenol
-
Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-[(2-methylphenyl)methyl]phenol
-
Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-[(2-methylphenyl)methyl]phenol
-
Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-[(3-methylphenyl)methyl]phenol
-
Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-[(3-methylphenyl)methyl]phenol
-
Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-[(4-fluorophenyl)methyl]phenol
-
Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-[(4-fluorophenyl)methyl]phenol
-
Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-[(pyridin-2-yl)methyl]phenol
-
Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-[(pyridin-2-yl)methyl]phenol
-
Plasmodium falciparum
2-(2,4-dichlorophenoxy)-5-[(pyridin-3-yl)methyl]phenol
-
Mycobacterium tuberculosis
2-(2,4-dichlorophenoxy)-5-[(pyridin-3-yl)methyl]phenol
-
Plasmodium falciparum
2-[2-(dimethylamino)-4-sulfanylphenoxy]-5-{[(2-phenylethyl)amino]methyl}phenol
-
Mycobacterium tuberculosis
2-[2-(dimethylamino)-4-sulfanylphenoxy]-5-{[(2-phenylethyl)amino]methyl}phenol
-
Plasmodium falciparum
2-[4-({[(2,3-dihydro-1-benzofuran-6-yl)methyl]amino}methyl)-2-hydroxyphenoxy]-5-methylbenzonitrile
-
Mycobacterium tuberculosis
2-[4-({[(2,3-dihydro-1-benzofuran-6-yl)methyl]amino}methyl)-2-hydroxyphenoxy]-5-methylbenzonitrile
-
Plasmodium falciparum
3'-methyl-4-[2-(methylamino)-4-(3-methylbutyl)phenoxy][1,1'-biphenyl]-3-ol
-
Mycobacterium tuberculosis
3'-methyl-4-[2-(methylamino)-4-(3-methylbutyl)phenoxy][1,1'-biphenyl]-3-ol
-
Plasmodium falciparum
3'-methyl-4-[2-(methylamino)-4-(propan-2-yl)phenoxy][1,1'-biphenyl]-3-ol
-
Mycobacterium tuberculosis
3'-methyl-4-[2-(methylamino)-4-(propan-2-yl)phenoxy][1,1'-biphenyl]-3-ol
-
Plasmodium falciparum
3'-methyl-4-{[3-(methylamino)[1,1'-biphenyl]-4-yl]oxy}[1,1'-biphenyl]-3-ol
-
Mycobacterium tuberculosis
3'-methyl-4-{[3-(methylamino)[1,1'-biphenyl]-4-yl]oxy}[1,1'-biphenyl]-3-ol
-
Plasmodium falciparum
3-chloro-4-[2-hydroxy-4-[(2-methylphenyl)methyl]phenoxy]benzonitrile
-
Mycobacterium tuberculosis
3-chloro-4-[2-hydroxy-4-[(2-methylphenyl)methyl]phenoxy]benzonitrile
-
Plasmodium falciparum
3-chloro-4-[2-hydroxy-4-[(pyridin-4-yl)methyl]phenoxy]benzonitrile
-
Mycobacterium tuberculosis
3-chloro-4-[2-hydroxy-4-[(pyridin-4-yl)methyl]phenoxy]benzonitrile
-
Plasmodium falciparum
4-[(3-ethyl[1,1'-biphenyl]-4-yl)oxy]-3'-methyl[1,1'-biphenyl]-3-ol
-
Mycobacterium tuberculosis
4-[(3-ethyl[1,1'-biphenyl]-4-yl)oxy]-3'-methyl[1,1'-biphenyl]-3-ol
-
Plasmodium falciparum
4-[2-(dimethylamino)-4-(3-methylbutyl)phenoxy]-3'-methyl[1,1'-biphenyl]-3-ol
-
Mycobacterium tuberculosis
4-[2-(dimethylamino)-4-(3-methylbutyl)phenoxy]-3'-methyl[1,1'-biphenyl]-3-ol
-
Plasmodium falciparum
4-[2-(dimethylamino)-4-(propan-2-yl)phenoxy]-3'-methyl[1,1'-biphenyl]-3-ol
-
Mycobacterium tuberculosis
4-[2-(dimethylamino)-4-(propan-2-yl)phenoxy]-3'-methyl[1,1'-biphenyl]-3-ol
-
Plasmodium falciparum
4-[2-ethyl-4-(3-methylbutyl)phenoxy]-3'-methyl[1,1'-biphenyl]-3-ol
-
Mycobacterium tuberculosis
4-[2-ethyl-4-(3-methylbutyl)phenoxy]-3'-methyl[1,1'-biphenyl]-3-ol
-
Plasmodium falciparum
4-[2-ethyl-4-(propan-2-yl)phenoxy]-3'-methyl[1,1'-biphenyl]-3-ol
-
Mycobacterium tuberculosis
4-[2-ethyl-4-(propan-2-yl)phenoxy]-3'-methyl[1,1'-biphenyl]-3-ol
-
Plasmodium falciparum
4-[4-({[2-(4-chlorophenyl)ethyl]amino}methyl)-2-hydroxyphenoxy]-3-(methylamino)anilinium
-
Mycobacterium tuberculosis
4-[4-({[2-(4-chlorophenyl)ethyl]amino}methyl)-2-hydroxyphenoxy]-3-(methylamino)anilinium
-
Plasmodium falciparum
4-{4-[(benzylamino)methyl]-2-hydroxyphenoxy}-3-chlorobenzonitrile
-
Mycobacterium tuberculosis
4-{4-[(benzylamino)methyl]-2-hydroxyphenoxy}-3-chlorobenzonitrile
-
Plasmodium falciparum
4-{[3-(dimethylamino)[1,1'-biphenyl]-4-yl]oxy}-3'-methyl[1,1'-biphenyl]-3-ol
-
Mycobacterium tuberculosis
4-{[3-(dimethylamino)[1,1'-biphenyl]-4-yl]oxy}-3'-methyl[1,1'-biphenyl]-3-ol
-
Plasmodium falciparum
5-(anilinomethyl)-2-[(3-ethyl[1,1'-biphenyl]-4-yl)oxy]phenol
-
Mycobacterium tuberculosis
5-(anilinomethyl)-2-[(3-ethyl[1,1'-biphenyl]-4-yl)oxy]phenol
-
Plasmodium falciparum
5-(anilinomethyl)-2-[2-(dimethylamino)-4-(3-methylbutyl)phenoxy]phenol
-
Mycobacterium tuberculosis
5-(anilinomethyl)-2-[2-(dimethylamino)-4-(3-methylbutyl)phenoxy]phenol
-
Plasmodium falciparum
5-(anilinomethyl)-2-[2-(dimethylamino)-4-(propan-2-yl)phenoxy]phenol
-
Mycobacterium tuberculosis
5-(anilinomethyl)-2-[2-(dimethylamino)-4-(propan-2-yl)phenoxy]phenol
-
Plasmodium falciparum
5-(anilinomethyl)-2-[2-(methylamino)-4-(3-methylbutyl)phenoxy]phenol
-
Mycobacterium tuberculosis
5-(anilinomethyl)-2-[2-(methylamino)-4-(3-methylbutyl)phenoxy]phenol
-
Plasmodium falciparum
5-(anilinomethyl)-2-[2-(methylamino)-4-(propan-2-yl)phenoxy]phenol
-
Mycobacterium tuberculosis
5-(anilinomethyl)-2-[2-(methylamino)-4-(propan-2-yl)phenoxy]phenol
-
Plasmodium falciparum
5-(anilinomethyl)-2-[2-ethyl-4-(3-methylbutyl)phenoxy]phenol
-
Mycobacterium tuberculosis
5-(anilinomethyl)-2-[2-ethyl-4-(3-methylbutyl)phenoxy]phenol
-
Plasmodium falciparum
5-(anilinomethyl)-2-[2-ethyl-4-(propan-2-yl)phenoxy]phenol
-
Mycobacterium tuberculosis
5-(anilinomethyl)-2-[2-ethyl-4-(propan-2-yl)phenoxy]phenol
-
Plasmodium falciparum
5-(anilinomethyl)-2-{[3-(dimethylamino)[1,1'-biphenyl]-4-yl]oxy}phenol
-
Mycobacterium tuberculosis
5-(anilinomethyl)-2-{[3-(dimethylamino)[1,1'-biphenyl]-4-yl]oxy}phenol
-
Plasmodium falciparum
5-(anilinomethyl)-2-{[3-(methylamino)[1,1'-biphenyl]-4-yl]oxy}phenol
-
Mycobacterium tuberculosis
5-(anilinomethyl)-2-{[3-(methylamino)[1,1'-biphenyl]-4-yl]oxy}phenol
-
Plasmodium falciparum
5-(cyclohexylmethyl)-2-(2,4-dichlorophenoxy)phenol
-
Mycobacterium tuberculosis
5-(cyclohexylmethyl)-2-(2,4-dichlorophenoxy)phenol
-
Plasmodium falciparum
5-(cyclohexylmethyl)-2-[(3-ethyl[1,1'-biphenyl]-4-yl)oxy]phenol
-
Mycobacterium tuberculosis
5-(cyclohexylmethyl)-2-[(3-ethyl[1,1'-biphenyl]-4-yl)oxy]phenol
-
Plasmodium falciparum
5-(cyclohexylmethyl)-2-[2-(dimethylamino)-4-(3-methylbutyl)phenoxy]phenol
-
Mycobacterium tuberculosis
5-(cyclohexylmethyl)-2-[2-(dimethylamino)-4-(3-methylbutyl)phenoxy]phenol
-
Plasmodium falciparum
5-(cyclohexylmethyl)-2-[2-(dimethylamino)-4-(propan-2-yl)phenoxy]phenol
-
Mycobacterium tuberculosis
5-(cyclohexylmethyl)-2-[2-(dimethylamino)-4-(propan-2-yl)phenoxy]phenol
-
Plasmodium falciparum
5-(cyclohexylmethyl)-2-[2-(methylamino)-4-(3-methylbutyl)phenoxy]phenol
-
Mycobacterium tuberculosis
5-(cyclohexylmethyl)-2-[2-(methylamino)-4-(3-methylbutyl)phenoxy]phenol
-
Plasmodium falciparum
5-(cyclohexylmethyl)-2-[2-(methylamino)-4-(propan-2-yl)phenoxy]phenol
-
Mycobacterium tuberculosis
5-(cyclohexylmethyl)-2-[2-(methylamino)-4-(propan-2-yl)phenoxy]phenol
-
Plasmodium falciparum
5-(cyclohexylmethyl)-2-[2-ethyl-4-(3-methylbutyl)phenoxy]phenol
-
Mycobacterium tuberculosis
5-(cyclohexylmethyl)-2-[2-ethyl-4-(3-methylbutyl)phenoxy]phenol
-
Plasmodium falciparum
5-(cyclohexylmethyl)-2-[2-ethyl-4-(propan-2-yl)phenoxy]phenol
-
Mycobacterium tuberculosis
5-(cyclohexylmethyl)-2-[2-ethyl-4-(propan-2-yl)phenoxy]phenol
-
Plasmodium falciparum
5-(cyclohexylmethyl)-2-{[3-(dimethylamino)[1,1'-biphenyl]-4-yl]oxy}phenol
-
Mycobacterium tuberculosis
5-(cyclohexylmethyl)-2-{[3-(dimethylamino)[1,1'-biphenyl]-4-yl]oxy}phenol
-
Plasmodium falciparum
5-(cyclohexylmethyl)-2-{[3-(methylamino)[1,1'-biphenyl]-4-yl]oxy}phenol
-
Mycobacterium tuberculosis
5-(cyclohexylmethyl)-2-{[3-(methylamino)[1,1'-biphenyl]-4-yl]oxy}phenol
-
Plasmodium falciparum
5-({[(2,3-dihydro-1-benzofuran-6-yl)methyl]amino}methyl)-2-[2-methyl-4-(methylamino)phenoxy]phenol
-
Mycobacterium tuberculosis
5-({[(2,3-dihydro-1-benzofuran-6-yl)methyl]amino}methyl)-2-[2-methyl-4-(methylamino)phenoxy]phenol
-
Plasmodium falciparum
5-({[2-(4-chlorophenyl)ethyl]amino}methyl)-2-[2-(dimethylamino)-4-ethylphenoxy]phenol
-
Mycobacterium tuberculosis
5-({[2-(4-chlorophenyl)ethyl]amino}methyl)-2-[2-(dimethylamino)-4-ethylphenoxy]phenol
-
Plasmodium falciparum
5-({[2-(4-chlorophenyl)ethyl]amino}methyl)-2-[2-ethyl-4-(sulfanylmethyl)phenoxy]phenol
-
Mycobacterium tuberculosis
5-({[2-(4-chlorophenyl)ethyl]amino}methyl)-2-[2-ethyl-4-(sulfanylmethyl)phenoxy]phenol
-
Plasmodium falciparum
5-butyl-2-(2,4-dichlorophenoxy)phenol
-
Mycobacterium tuberculosis
5-butyl-2-(2,4-dichlorophenoxy)phenol
-
Plasmodium falciparum
5-chloro-2-(2,4-dichlorophenoxy)phenol
-
Mycobacterium tuberculosis
5-chloro-2-(2,4-dichlorophenoxy)phenol
-
Plasmodium falciparum
5-cyclohexyl-2-(2-hydrazinyl-4-propylphenoxy)phenol
-
Mycobacterium tuberculosis
5-cyclohexyl-2-(2-hydrazinyl-4-propylphenoxy)phenol
-
Plasmodium falciparum
5-[(benzylamino)methyl]-2-[2-(dimethylamino)-4-ethylphenoxy]phenol
-
Mycobacterium tuberculosis
5-[(benzylamino)methyl]-2-[2-(dimethylamino)-4-ethylphenoxy]phenol
-
Plasmodium falciparum
triclosan
-
Mycobacterium tuberculosis
triclosan
-
Plasmodium falciparum
Other publictions for EC 1.3.1.9
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
748518
Xia
Discovery of a cofactor-indep ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618
Life Sci. Alliance
1
e201800025
2018
-
-
1
-
8
-
6
-
-
-
-
-
-
19
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
6
-
-
1
-
-
8
-
6
6
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
741435
Martinelli
Functional, thermodynamics, st ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Sci. Rep.
7
46696
2017
-
-
-
-
-
-
14
-
-
-
-
2
-
162
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
1
-
-
7
-
-
-
1
-
-
-
7
14
-
-
-
-
-
2
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
740080
Neckles
Selectivity of pyridone- and d ...
Yersinia pestis, Yersinia pestis A1122
Biochemistry
55
2992-3006
2016
-
-
1
1
6
-
23
11
-
-
-
2
-
2
-
-
1
-
-
-
-
-
10
-
-
-
-
10
-
-
-
2
4
-
21
-
-
1
2
1
6
-
21
23
4
11
-
-
-
2
-
-
-
1
-
-
-
-
10
-
-
-
-
10
-
-
-
-
-
-
-
-
9
9
740290
Ghattas
Analysis of enoyl-acyl carrier ...
Escherichia coli, Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv, Plasmodium falciparum
Chem. Biol. Drug Des.
87
131-142
2016
-
-
-
-
-
-
3
-
-
-
-
4
-
15
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
3
-
-
-
-
3
-
-
-
-
-
4
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
740399
Cheng
A new strategy for strain impr ...
Aurantiochytrium sp., Aurantiochytrium sp. CGMCC 6208
Enzyme Microb. Technol.
93-94
182-190
2016
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
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-
-
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-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
740484
Huang
Functional characterization of ...
Pseudomonas aeruginosa
Front. Microbiol.
7
1903
2016
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
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-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
740527
Yao
Enoyl-acyl carrier protein red ...
Listeria monocytogenes
Infect. Immun.
84
3597-3607
2016
-
-
1
-
-
-
1
-
1
-
1
1
-
3
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
1
-
-
1
-
1
1
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
2
2
-
-
-
742918
Demissie
An efficient and economical a ...
Francisella tularensis subsp. tularensis
J. Biomol. Screen.
21
391-398
2016
-
1
1
-
1
-
1
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
-
-
2
-
-
-
-
-
-
-
-
-
1
1
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
747582
Guardia
N-Benzyl-4-((heteroaryl)methy ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618
ChemMedChem
11
687-701
2016
-
-
1
-
-
-
26
-
-
-
-
-
-
20
-
-
1
-
-
-
-
-
2
-
1
-
-
-
1
-
-
1
-
-
28
-
-
1
1
-
-
-
28
26
-
-
-
-
-
-
-
-
-
1
-
-
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
739819
Jordan
Crystallographic insights into ...
Escherichia coli
Acta Crystallogr. Sect. F
71
1521-1530
2015
-
-
1
1
-
-
10
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
1
-
-
-
10
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
739906
Vick
Escherichia coli enoyl-acyl ca ...
Escherichia coli
Appl. Environ. Microbiol.
81
1406-1416
2015
-
-
-
-
-
-
8
1
-
1
-
1
-
3
-
-
1
-
-
-
-
-
2
-
-
-
-
1
1
-
-
2
2
-
-
-
-
-
2
-
-
-
-
8
2
1
-
1
-
1
-
-
-
1
-
-
-
-
2
-
-
-
-
1
1
-
-
-
-
-
-
-
1
1
740150
Mehboob
Structural and biological eval ...
Francisella tularensis subsp. tularensis, Francisella tularensis subsp. tularensis Schu 4
Bioorg. Med. Chem. Lett.
25
1292-1296
2015
-
-
-
-
-
-
10
-
-
-
-
2
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
10
-
-
-
1
-
-
-
10
10
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
740153
Kim
Discovery of a potent enoyl-ac ...
Staphylococcus aureus, Staphylococcus aureus MRSA
Bioorg. Med. Chem. Lett.
25
4481-4486
2015
-
-
-
-
-
-
55
-
-
-
-
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5
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2
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-
1
-
-
53
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1
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-
-
53
55
-
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-
-
2
-
-
-
-
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740250
Lee
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Crystal structures of Pseudomo ...
Pseudomonas aeruginosa
Bull. Korean Chem. Soc.
36
322-326
2015
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1
1
-
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-
1
-
1
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1
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2
1
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2
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1
2
1
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1
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1
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-
-
2
1
-
-
-
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740846
Sink
Design, synthesis, and evaluat ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
J. Med. Chem.
58
613-624
2015
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4
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2
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24
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2
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24
26
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2
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-
4
-
-
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-
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740920
Chollet
Crystal structure of the enoyl ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
J. Struct. Biol.
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328-337
2015
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1
1
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1
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2
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1
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1
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1
1
1
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1
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2
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1
-
-
-
-
2
-
-
-
1
-
-
-
-
-
-
-
-
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741013
Owono Owono
Virtually designed triclosan-b ...
Mycobacterium tuberculosis, Plasmodium falciparum
Mol. Inform.
34
292-307
2015
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112
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2
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38
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38
112
-
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-
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-
-
-
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743553
Gonzalez-Thuillier
Sunflower (Helianthus annuus) ...
Helianthus annuus
Planta
241
43-56
2015
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1
1
-
-
-
-
-
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-
2
-
1
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-
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5
-
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2
1
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-
-
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2
-
1
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-
2
4
2
-
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2
-
-
5
-
-
2
2
-
-
-
-
-
-
-
2
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1
2
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747703
Rotta
Piperazine derivatives Synthe ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618
Eur. J. Med. Chem.
90
436-447
2015
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10
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2
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1
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9
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1
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9
10
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-
-
-
2
-
-
-
-
-
-
-
-
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1
1
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-
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740302
Liu
Enoyl acyl carrier protein red ...
Acinetobacter sp. RS1
Chem. Commun. (Camb.)
50
9729-9732
2014
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1
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1
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-
1
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1
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8
1
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2
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1
2
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1
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1
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8
1
-
-
-
-
-
-
-
-
-
-
-
-
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740323
Stec
Biological evaluation of poten ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
ChemMedChem
9
2528-2537
2014
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1
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28
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2
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160
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1
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4
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1
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1
1
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-
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28
-
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2
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1
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-
-
-
4
-
-
-
-
-
-
-
-
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741373
Jiang
Crystal structures and kinetic ...
Candidatus Liberibacter asiaticus
Protein Sci.
23
366-377
2014
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1
1
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1
2
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1
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4
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-
1
-
-
-
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1
1
-
-
-
-
-
-
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1
2
-
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-
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1
1
1
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-
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1
2
2
-
-
1
-
-
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-
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
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747700
Pedgaonkar
Development of 2-(4-oxoquinaz ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618
Eur. J. Med. Chem.
86
613-627
2014
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1
1
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28
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2
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1
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1
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-
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16
-
1
1
-
-
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-
16
28
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-
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-
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-
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-
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-
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-
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-
2
-
1
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-
1
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724240
Hu
Structures of trans-2-enoyl-Co ...
Yersinia pestis
Biochem. J.
449
79-89
2013
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1
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2
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2
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1
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-
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-
1
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-
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-
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724544
Neves
Discovery of new potential hit ...
Plasmodium falciparum
Bioorg. Med. Chem. Lett.
23
2436-2441
2013
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3
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2
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3
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3
3
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-
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-
-
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-
-
-
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725286
Kingry
The Francisella tularensis Fab ...
Francisella tularensis, Francisella tularensis SCHU S4
J. Bacteriol.
195
351-358
2013
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1
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1
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-
-
-
-
-
-
-
-
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1
1
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725690
Kwon
Panosialins, inhibitors of eno ...
Mycobacterium tuberculosis, Streptococcus pneumoniae
J. Microbiol. Biotechnol.
23
184-188
2013
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8
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8
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8
8
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-
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740140
Cheng
Design, synthesis, and biologi ...
Toxoplasma gondii
Bioorg. Med. Chem. Lett.
23
2035-2043
2013
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20
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1
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1
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1
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1
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7
-
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1
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7
20
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1
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-
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-
1
-
-
-
-
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740838
Belluti
Design, synthesis, and biologi ...
Plasmodium falciparum
J. Med. Chem.
56
7516-7526
2013
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1
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1
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1
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1
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1
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1
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1
1
1
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1
15
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1
-
-
-
1
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-
1
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-
-
-
-
-
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723871
Park
Crystallization and preliminar ...
Aliivibrio fischeri
Acta Crystallogr. Sect. F
68
78-80
2012
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1
1
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1
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1
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-
-
-
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-
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-
-
-
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1
-
1
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-
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-
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1
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-
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-
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-
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1
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725668
Hevener
Discovery of a novel and poten ...
Francisella tularensis, Francisella tularensis SCHU S4
J. Med. Chem.
55
268-279
2012
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3
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3
3
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-
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725760
da Costa
Conformational changes in 2-tr ...
Mycobacterium tuberculosis
J. Mol. Model.
18
1779-1790
2012
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1
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1
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1
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-
-
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-
-
-
-
-
-
-
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-
-
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726421
Lei
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Identification of two enoyl-AC ...
Brucella abortus
Prog. Biochem. Biophys.
39
464-471
2012
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2
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-
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-
-
-
-
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-
-
-
-
-
-
-
-
-
-
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-
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-
-
-
2
-
-
-
-
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-
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1
2
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726448
Lindert
Dynamics of Plasmodium falcipa ...
Plasmodium falciparum
Protein Sci.
21
1734-1745
2012
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1
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-
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-
-
-
-
-
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-
-
1
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-
-
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
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726501
Hirschbeck
Structure of the Yersinia pest ...
Yersinia pestis
Structure
20
89-100
2012
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1
1
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3
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1
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1
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3
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1
1
1
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3
3
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
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748433
Da Costa
Conformational changes in 2-t ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618
J. Mol. Model.
18
1779-1790
2012
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20
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-
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
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2
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-
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-
-
-
-
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-
-
-
-
-
-
-
-
-
-
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1
1
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724551
Deraeve
Chemical synthesis, biological ...
Mycobacterium tuberculosis
Bioorg. Med. Chem.
19
6225-6232
2011
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3
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-
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-
-
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-
-
-
-
-
-
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-
-
-
-
-
-
-
3
-
-
-
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-
-
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-
-
-
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-
-
-
-
-
-
-
-
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724889
de Medeiros
Enzyme mechanism and slow-onse ...
Plasmodium falciparum
Enzyme Res.
2011
642758
2011
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1
2
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1
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1
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1
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1
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-
-
-
-
-
-
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1
1
2
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-
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-
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-
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-
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-
1
-
-
-
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1
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2
2
725169
Banerjee
Benzothiophene carboxamide der ...
Plasmodium falciparum
IUBMB Life
63
1101-1110
2011
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3
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3
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1
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2
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3
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3
3
2
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-
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-
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-
-
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-
-
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1
-
-
-
-
-
-
-
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-
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725170
Maity
Effect of substrate binding lo ...
Plasmodium falciparum
IUBMB Life
63
30-41
2011
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1
1
9
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1
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3
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2
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3
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1
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1
9
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3
1
2
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-
-
-
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-
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Liu
Mechanism and inhibition of th ...
Burkholderia pseudomallei 1710b, Burkholderia pseudomallei
J. Antimicrob. Chemother.
66
564-573
2011
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5
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11
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5
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4
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1
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4
4
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5
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11
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5
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5
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Kim
Crystal structures of enoyl-AC ...
Bacillus subtilis 168, Bacillus subtilis
J. Mol. Biol.
406
403-415
2011
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1
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1
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1
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726284
Li
Determination of the crystal s ...
Xanthomonas oryzae
PLoS ONE
6
e26743
2011
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1
12
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2
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1
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1
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1
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Receptor based 3D-QSAR to iden ...
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Dimeric and tetrameric forms o ...
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Lu
Mechanism and inhibition of th ...
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Novel enoyl-ACP reductase (Fab ...
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Structure of the Francisella t ...
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1
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Triclosan resistance of Pseudo ...
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Detection of Escherichia coli ...
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Maity
X-ray crystallographic analysi ...
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3
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3
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1
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3
3
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Luckner
A slow, tight binding inhibit ...
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1
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2
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1
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1
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2
1
1
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1
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Vasconcelos
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Kinetic and equilibrium mecha ...
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1
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1
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1
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Gurvitz
Triclosan inhibition of mycob ...
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1
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2
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1
1
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748680
Molle
Phosphorylation of InhA inhib ...
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1591-1605
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1
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1
1
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3
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4
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1
1
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2
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4
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4
696691
Sampson
Spiro-naphthyridinone piperidi ...
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2009
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2
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18
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2
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3
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1
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696692
Ramnauth
2,3,4,5-Tetrahydro-1H-pyrido[2 ...
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Bioorg. Med. Chem. Lett.
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2
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2
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2
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30
29
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1
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Massengo-Tiasse
Diversity in enoyl-acyl carrie ...
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Cell. Mol. Life Sci.
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2009
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2
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8
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2
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2
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2
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2
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8
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2
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2
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697740
Frecer
Design and in silico screening ...
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3009-3019
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1
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1
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1
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-
-
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1
1
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11
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1
-
1
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-
11
11
1
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-
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1
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-
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1
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700214
Morde
Molecular modeling studies, sy ...
Plasmodium falciparum
Mol. Divers.
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60
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1
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1
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1
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1
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60
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1
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-
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711351
Kwon
Aquastatin A, a new inhibitor ...
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2061-2064
2009
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1
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2
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1
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1
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1
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2
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1
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1
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-
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2
2
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2
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1
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712208
Kapoor
Design, development, synthesis ...
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1
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2
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1
1
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2
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1
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1
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1
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Lu
Inhibitors of FabI, an enzyme ...
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1
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12
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Sharma
Combined effect of epigallocat ...
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1
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1
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2
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1
1
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2
2
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1
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1
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1
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Tipparaju
Design and synthesis of 2-pyri ...
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3565-3569
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31
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Massengo-Tiasse
Vibrio cholerae FabV defines a ...
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1
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1
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1
1
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1
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3
1
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Kumar
CoMFA based de novo design of ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
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47
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689435
Karioti
Inhibiting enoyl-ACP reductase ...
Escherichia coli, Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv, Plasmodium falciparum
Phytomedicine
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1125-1129
2008
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Dayan
A pathogenic fungi diphenyl et ...
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1
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2
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1
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1
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Saito
Crystal structure of enoyl-acy ...
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Banerjee
Epigallocatechin gallate is a ...
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-
1
-
-
-
-
-
1
-
-
1
2
-
-
-
1
1
1
-
-
-
-
2
2
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
697255
Subba Rao
Structure-based design of a no ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Chem. Biol. Drug Des.
72
444-449
2008
-
1
-
-
-
-
2
-
-
-
-
-
-
14
-
-
-
-
-
-
-
-
-
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-
-
-
-
-
-
-
1
-
-
-
-
1
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
697336
Tipparaju
Design and synthesis of aryl e ...
Bacillus anthracis
ChemMedChem
3
1250-1268
2008
-
1
-
-
-
-
47
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
1
-
-
45
-
1
-
1
-
-
-
45
47
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
699613
Stigliani
Binding of the tautomeric form ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
J. Mol. Graph. Model.
27
536-545
2008
-
1
-
-
-
-
1
-
-
-
-
-
-
13
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
747498
Subba Rao
Structure-based design of a n ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618
Chem. Biol. Drug Des.
72
444-449
2008
-
-
-
-
-
-
2
-
-
-
-
-
-
20
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
672556
Kitagawa
4-Pyridone derivatives as new ...
Escherichia coli, Staphylococcus aureus
Bioorg. Med. Chem.
15
1106-1116
2007
-
2
1
-
-
-
62
-
-
-
-
2
-
2
-
-
1
-
-
-
-
-
3
-
2
-
-
-
1
-
-
2
-
-
33
-
2
1
2
-
-
-
33
62
-
-
-
-
-
2
-
-
-
1
-
-
-
-
3
-
2
-
-
-
1
-
-
-
-
-
-
-
-
-
684170
Kim
Crystallization and preliminar ...
Bacillus subtilis 168, Bacillus subtilis
Acta Crystallogr. Sect. F
63
246-248
2007
-
-
-
-
-
-
-
-
-
-
-
-
-
90
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
684850
Nicola
Discovery of novel inhibitors ...
Plasmodium falciparum
Biochem. Biophys. Res. Commun.
358
686-691
2007
-
-
1
-
-
-
17
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
17
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
685582
Bonnac
Synthesis of 4-phenoxybenzamid ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Bioorg. Med. Chem. Lett.
17
4588-4591
2007
-
-
-
-
-
-
3
-
-
-
-
-
-
14
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
1
-
-
-
1
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
686787
Cai
Biochemical characterization o ...
Eimeria tenella
FEMS Microbiol. Lett.
272
238-244
2007
-
-
1
-
-
-
2
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
-
1
-
-
1
1
-
-
-
1
2
-
1
-
-
-
-
-
-
-
1
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
687327
Takahata
Discovery of 4-pyridone deriva ...
Escherichia coli, Staphylococcus aureus
J. Antibiot.
60
123-128
2007
-
-
2
-
3
-
7
-
-
-
-
-
-
2
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
10
-
-
2
2
-
3
-
10
7
-
-
-
-
-
-
-
-
-
2
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
687332
Park
Antistaphylococcal activities ...
Staphylococcus aureus, Staphylococcus aureus RN4220
J. Antimicrob. Chemother.
60
568-574
2007
-
-
-
-
1
-
2
-
-
-
-
-
-
20
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
687598
Freundlich
X-ray structural analysis of P ...
Plasmodium falciparum
J. Biol. Chem.
282
25436-25444
2007
1
-
-
1
-
-
29
-
-
-
-
-
-
3
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
28
1
-
-
1
1
-
-
28
29
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
688247
Kumar
Discovery of a rhodanine class ...
Plasmodium falciparum
J. Med. Chem.
50
2665-2675
2007
-
-
-
-
-
-
45
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
45
-
-
-
1
-
-
-
45
45
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
688694
Dias
Crystallographic studies on th ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
J. Struct. Biol.
159
369-380
2007
-
-
-
1
2
-
1
-
-
-
-
-
-
14
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
1
2
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
689328
Lu
Type I and type II fatty acid ...
Eimeria tenella
Parasitology
134
1949-1962
2007
-
-
1
-
-
-
1
2
-
-
1
-
-
4
-
-
1
-
-
-
-
-
2
1
-
-
-
-
-
-
-
1
-
-
1
-
-
1
1
-
-
-
1
1
-
2
-
-
1
-
-
-
-
1
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
689970
Lee
Crystal structure of the Helic ...
Helicobacter pylori
Proteins Struct. Funct. Bioinform.
69
691-694
2007
-
-
1
1
-
-
3
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
1
-
-
-
3
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
747251
He
Inhibition of the Mycobacteri ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618
Bioorg. Med. Chem.
15
6649-6658
2007
-
-
-
1
-
-
12
-
-
-
-
-
-
20
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
1
-
-
6
12
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
749238
Kruh
Probing mechanisms of resista ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618
Protein Sci.
16
1617-1627
2007
-
-
1
-
3
-
1
-
-
-
1
-
-
19
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
3
-
-
1
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
671150
Muench
Expression, purification and p ...
Toxoplasma gondii
Acta Crystallogr. Sect. F
F62
604-606
2006
-
1
1
1
-
-
1
-
-
-
-
1
-
1
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
1
1
1
1
-
-
-
1
-
-
-
-
-
1
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
671166
Saito
Crystallization and preliminar ...
Streptococcus pneumoniae
ACTA CRYSTALLOGR. SECT. F
62
576-578
2006
-
1
1
1
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
672553
Chhibber
Novel diphenyl ethers: design, ...
Escherichia coli, Plasmodium falciparum
Bioorg. Med. Chem.
14
8086-8098
2006
-
2
2
-
-
-
20
-
-
-
-
2
-
4
-
-
2
-
-
-
-
-
4
-
2
-
-
-
2
-
-
2
12
-
35
-
2
2
2
-
-
-
35
20
12
-
-
-
-
2
-
-
-
2
-
-
-
-
4
-
2
-
-
-
2
-
-
-
-
-
-
-
-
-
673230
Oliveira
Slow-onset inhibition of 2-tra ...
Mycobacterium tuberculosis
Curr. Pharm. Des.
12
2409-2424
2006
-
1
-
-
1
-
2
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
1
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
675299
Tasdemir
Inhibition of Plasmodium falci ...
Plasmodium falciparum
J. Med. Chem.
49
3345-3353
2006
-
1
1
-
-
-
14
-
-
-
-
1
-
1
-
-
1
-
-
-
-
-
2
-
1
-
-
-
1
-
-
1
2
-
13
-
1
1
1
-
-
-
13
14
2
-
-
-
-
1
-
-
-
1
-
-
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
675303
Rafi
Insight through molecular mech ...
Escherichia coli
J. Med. Chem.
49
4574-4580
2006
-
1
-
-
-
-
4
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
1
-
-
-
-
4
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
675309
He
Pyrrolidine carboxamides as a ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
J. Med. Chem.
49
6308-6323
2006
-
1
1
-
-
-
2
-
-
-
-
1
-
14
-
-
1
-
-
-
-
1
1
-
1
-
-
-
1
-
-
1
-
-
2
-
1
1
1
-
-
-
2
2
-
-
-
-
-
1
-
-
-
1
-
-
-
1
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
675385
Oliveira
Crystallographic and pre-stead ...
Mycobacterium tuberculosis
J. Mol. Biol.
359
646-666
2006
-
1
1
1
3
-
1
-
-
-
4
1
-
2
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
1
-
-
-
-
1
1
1
1
3
-
-
1
-
-
-
-
4
1
-
-
-
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
672640
Schroeder
Molecular dynamics simulation ...
Mycobacterium tuberculosis
Biophys. J.
89
876-884
2005
-
1
-
-
2
-
-
3
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
1
-
2
-
-
-
-
3
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
673193
Moir
Identification of inhibitors o ...
Staphylococcus aureus
Curr. Drug Targets Infect. Disord.
5
297-305
2005
-
1
-
-
-
-
5
-
-
-
-
1
-
5
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
1
-
-
-
-
5
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
676367
Tasdemir
Anti-protozoal and plasmodial ...
Plasmodium falciparum
Phytochemistry
66
355-362
2005
-
1
-
-
-
-
1
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
1
-
-
-
-
1
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
747286
Schroeder
Molecular dynamics simulation ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618
Biophys. J.
89
876-884
2005
-
-
-
-
2
-
-
-
-
-
-
-
-
19
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
2
-
-
-
-
-
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Kapoor
Kinetic and structural analysi ...
Plasmodium falciparum
Biochem. J.
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654544
Kapoor
Mutational analysis of the tri ...
Plasmodium falciparum
Biochem. J.
381
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2004
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654731
Protasevich
Role of inhibitor aliphatic ch ...
Escherichia coli
Biochemistry
43
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2004
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655226
Oliveira
-
An inorganic iron complex that ...
Mycobacterium tuberculosis
Chem. Commun. (Camb.)
2004
312-313
2004
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656471
Sivaraman
Inhibition of the bacterial en ...
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J. Med. Chem.
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2004
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657142
Kirmizibekmez
Inhibiting activities of the s ...
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Planta Med.
70
711-717
2004
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654069
Muench
Expression, purification and c ...
Plasmodium falciparum
Acta Crystallogr. Sect. D
59
1246-1248
2003
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654510
Marrakchi
Characterization of Streptococ ...
Streptococcus pneumoniae
Biochem. J.
370
1055-1062
2003
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2
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654701
Sivaraman
Structure-activity studies of ...
Escherichia coli
Biochemistry
42
4406-4413
2003
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12
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12
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Seefeld
Indole naphthyridinones as inh ...
Escherichia coli, Haemophilus influenzae, Staphylococcus aureus, Streptococcus pneumoniae
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2003
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1
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4
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390900
Lee
Crystallization and preliminar ...
Helicobacter pylori
Acta Crystallogr. Sect. D
58
1071-1073
2002
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654426
Lee
Characterization of a novel en ...
Rhodobacter sphaeroides
Biochem. Biophys. Res. Commun.
299
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2002
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2
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3
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2
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390896
Suguna
Structural basis for triclosan ...
Plasmodium falciparum
Biochem. Biophys. Res. Commun.
283
224-228
2001
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390897
Marcinkeviciene
Enoyl-ACP reductase (FabI) of ...
Haemophilus influenzae
Arch. Biochem. Biophys.
390
101-108
2001
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1
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Kapoor
Kinetic determinants of the in ...
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Biochem. Biophys. Res. Commun.
289
832-837
2001
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747579
Nguyen
-
The nonenzymatic activation o ...
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Chemistry
4
35-40
2001
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1
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285683
Fisher
The x-ray structure of Brassic ...
Brassica napus
Structure
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339-347
2000
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Heath
The enoyl-[acyl-carrier-protei ...
Bacillus subtilis
J. Biol. Chem.
275
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2000
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3
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1
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2
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1
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1
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2
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4
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4
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1
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1
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747054
Parikh
Inhibition of InhA, the enoyl ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis ATCC 25618, Mycolicibacterium smegmatis, Mycolicibacterium smegmatis ATCC 700084
Biochemistry
39
7645-7650
2000
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8
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2
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2
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2
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1
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5
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4
2
13
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8
-
2
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13
2
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390892
Ward
Kinetic and structural charact ...
Escherichia coli
Biochemistry
38
12514-12525
1999
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Parikh
Roles of tyrosine 158 and lysi ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Biochemistry
38
13623-13634
1999
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Roujeinikova
Inhibitor binding studies on e ...
Brassica napus
J. Biol. Chem.
274
30811-30817
1999
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1
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Hoang
Characterization of Pseudomona ...
Pseudomonas aeruginosa
J. Bacteriol.
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1999
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Baldock
The x-ray structure of Escheri ...
Escherichia coli
J. Mol. Biol.
284
1529-1546
1998
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Basso
Mechanisms of isoniazid resist ...
Mycobacterium tuberculosis
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Bergler
The enoyl-[acyl-carrier-protei ...
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1996
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Crystallization of the NADH-sp ...
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Slabas
Immunological detection of NAD ...
Brassica napus
Biochim. Biophys. Acta
1039
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1990
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Inhibition and covalent modifi ...
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Cottingham
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Purified enoyl-[acyl-carrier-p ...
Brassica napus
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390877
Slabas
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Induction, purification and ch ...
Brassica napus
Biochim. Biophys. Acta
877
271-280
1986
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390887
Slabas
Oilseed rape NADH enoyl acyl-c ...
Brassica napus
Biochem. Soc. Trans.
14
581-582
1986
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285668
Shimakata
Purification and characterizat ...
Spinacia oleracea
Arch. Biochem. Biophys.
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77-91
1982
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285669
Shimakata
The procaryotic nature of the ...
Carthamus tinctorius
Arch. Biochem. Biophys.
217
144-154
1982
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285677
Shimakata
Fatty acid synthetase of Spina ...
Spinacia oleracea
Plant Physiol.
69
1257-1262
1982
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285678
Caughey
The characteristics of some co ...
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1982
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390878
Lessire
Nature of the fatty acid synth ...
Allium ampeloprasum
Plant Physiol.
73
614-618
1982
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390496
Saito
Steric course of reaction cata ...
Escherichia coli
Eur. J. Biochem.
116
581-586
1981
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390501
Saito
Incorporation of hydrogen atom ...
Escherichia coli
Biochim. Biophys. Acta
618
202-213
1980
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Seyama
Stereochemical studies of hydr ...
Corynebacterium ammoniagenes
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1167-1173
1977
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390500
Weeks
Studies on the mechanism of fa ...
Escherichia coli
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1180-1189
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