Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-bromo-N-(4-fluorobenzyl)-1-benzothiophene-2-carboxamide | competitive kinetics with cofactor NADH and uncompetitive kinetics with the substrate crotonyl-CoA | Plasmodium falciparum | |
3-bromo-N-[4-(trifluoromethyl)benzyl]-1-benzothiophene-2-carboxamide | competitive kinetics with cofactor NADH and uncompetitive kinetics with the substrate crotonyl-CoA | Plasmodium falciparum | |
triclosan | - |
Plasmodium falciparum |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Plasmodium falciparum | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
crotonyl-CoA + NADH + H+ | - |
Plasmodium falciparum | butyryl-CoA + NAD+ | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000018 | - |
3-bromo-N-(4-fluorobenzyl)-1-benzothiophene-2-carboxamide | substrate NADH, pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | |
0.000091 | - |
3-bromo-N-(4-fluorobenzyl)-1-benzothiophene-2-carboxamide | substrate crotonyl-CoA, pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000089 | - |
pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | triclosan | |
0.000115 | - |
pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | 3-bromo-N-(4-fluorobenzyl)-1-benzothiophene-2-carboxamide | |
0.000463 | - |
pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | 3-bromo-N-[4-(trifluoromethyl)benzyl]-1-benzothiophene-2-carboxamide |