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Literature summary for 1.3.1.9 extracted from
- Diversity in enoyl-acyl carrier protein reductases (2009), Cell. Mol. Life Sci., 66, 1507-1517.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | enoyl-acyl carrier protein reductase inhibitors turn out to be clinically useful antimicrobials | Escherichia coli |
| medicine | enoyl-acyl carrier protein reductase inhibitors turn out to be clinically useful antimicrobials | Mycobacterium tuberculosis |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| diazaborine | - |
Escherichia coli |  |
| diazaborine | - |
Mycobacterium tuberculosis | |
| isoniazid | - |
Escherichia coli | |
| isoniazid | - |
Mycobacterium tuberculosis | |
| triclosan | - |
Escherichia coli | |
| triclosan | - |
Mycobacterium tuberculosis | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| trans-2,3-dehydracyl-[acyl-carrier protein] + NADH + H+ | Escherichia coli | - |
acyl-[acyl-carrier protein] + NAD+ | - |
? | |
| trans-2,3-dehydracyl-[acyl-carrier protein] + NADH + H+ | Mycobacterium tuberculosis | - |
acyl-[acyl-carrier protein] + NAD+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
| Mycobacterium tuberculosis | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| trans-2,3-dehydracyl-[acyl-carrier protein] + NADH + H+ | - |
Escherichia coli | acyl-[acyl-carrier protein] + NAD+ | - |
? | |
| trans-2,3-dehydracyl-[acyl-carrier protein] + NADH + H+ | - |
Mycobacterium tuberculosis | acyl-[acyl-carrier protein] + NAD+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| enoyl-acyl carrier protein reductase | - |
Escherichia coli |
| enoyl-acyl carrier protein reductase | - |
Mycobacterium tuberculosis |
| ENR | - |
Escherichia coli |
| ENR | - |
Mycobacterium tuberculosis |
| FabI | - |
Escherichia coli |
| InhA | - |
Mycobacterium tuberculosis |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADH | - |
Escherichia coli | |
| NADH | - |
Mycobacterium tuberculosis | |
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Release 2023.1 (January 2023)
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