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Literature summary for 1.3.1.9 extracted from

  • Sharma, S.K.; Kumar, G.; Kapoor, M.; Surolia, A.
    Combined effect of epigallocatechin gallate and triclosan on enoyl-ACP reductase of Mycobacterium tuberculosis (2008), Biochem. Biophys. Res. Commun., 368, 12-17.
    View publication on PubMed
Search for more literature for 1.3.1.9

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli in BL-21(DE3) cells Mycobacterium tuberculosis

Inhibitors

Inhibitors Comment Organism Structure
epigallocatechin gallate
-
 Mycobacterium tuberculosis
triclosan
-
 Mycobacterium tuberculosis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
28500
-
 SDS-PAGE Mycobacterium tuberculosis

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA affinity column chromatography Mycobacterium tuberculosis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-[acyl-carrier protein] + NAD+
-
 Mycobacterium tuberculosis trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+
-
 ?

Synonyms

Synonyms Comment Organism
enoyl-ACP reductase
-
 Mycobacterium tuberculosis
enoyl-acyl carrier protein reductase
-
 Mycobacterium tuberculosis
InhA
-
 Mycobacterium tuberculosis

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Mycobacterium tuberculosis

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0028
-
 in 30 mM PIPES buffer, 150 mM NaCl, 10% glycerol (pH 8.0) Mycobacterium tuberculosis triclosan
0.0174
-
 in 30 mM PIPES buffer, 150 mM NaCl, 10% glycerol (pH 8.0) Mycobacterium tuberculosis epigallocatechin gallate