Literature summary for 1.3.1.86 extracted from

Liu, H.; Reynolds, K.A.
Precursor supply for polyketide biosynthesis: the role of crotonyl-CoA reductase (2001), Metab. Eng., 3, 40-48.

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Organism

Organism	UniProt	Comment	Textmining
Streptomyces virginiae	-	strain C730.1	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
crotonyl-CoA + NADPH + H+	-	Streptomyces virginiae	butyryl-CoA + NADP+	-	ir

Cofactor

Cofactor	Comment	Organism	Structure
NADPH	-	Streptomyces virginiae

Expression

Organism	Comment	Expression
Streptomyces virginiae	the addition of 1.0 g/l L-lysine induces expression of the ccr gene in Streptomyces cinnamonensis strain C730.1 in chemically defined medium containing mainly D-glucose (12 g/l), L-tyrosine (3.3 g/l), and either L-valine (6.7 g/l) or L-leucine (7.5 g/l) as carbon and nitrogen sources	up

General Information

General Information	Comment	Organism
physiological function	CCR provides butyryl-CoA precursor for monensin A biosynthesis	Streptomyces virginiae

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Release 2023.1 (January 2023)