Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cereibacter sphaeroides | - |
- |
- |
Methylorubrum extorquens | - |
- |
- |
Streptomyces coelicolor | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
crotonyl-CoA + CO2 + NADPH + H+ | - |
Cereibacter sphaeroides | (2S)-ethylmalonyl-CoA + NADP+ | - |
r | |
crotonyl-CoA + CO2 + NADPH + H+ | - |
Streptomyces coelicolor | (2S)-ethylmalonyl-CoA + NADP+ | - |
r | |
crotonyl-CoA + CO2 + NADPH + H+ | - |
Methylorubrum extorquens | (2S)-ethylmalonyl-CoA + NADP+ | - |
r | |
additional information | the enzyme also catalyzes the reduction of crotonyl-CoA to butyryl-CoA in the absence of CO2, but with only about one tenth of the maximum rate | Cereibacter sphaeroides | ? | - |
? | |
additional information | the enzyme also catalyzes the reduction of crotonyl-CoA to butyryl-CoA in the absence of CO2, but with only about one tenth of the maximum rate | Streptomyces coelicolor | ? | - |
? | |
additional information | the enzyme also catalyzes the reduction of crotonyl-CoA to butyryl-CoA in the absence of CO2, but with only about one tenth of the maximum rate | Methylorubrum extorquens | ? | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Cereibacter sphaeroides | |
NADP+ | - |
Streptomyces coelicolor | |
NADP+ | - |
Methylorubrum extorquens | |
NADPH | - |
Cereibacter sphaeroides | |
NADPH | - |
Streptomyces coelicolor | |
NADPH | - |
Methylorubrum extorquens |
Organism | Comment | Expression |
---|---|---|
Cereibacter sphaeroides | although the reaction is reversible, the activity of crotonyl-CoA carboxylase/reductase is up-regulated at least 60fold for Rhodobacter sphaeroides during growth with acetate versus succinate | up |
Streptomyces coelicolor | although the reaction is reversible, the activity of crotonyl-CoA carboxylase/reductase is up-regulated at least 60fold for Rhodobacter sphaeroides during growth with acetate versus succinate | up |
Methylorubrum extorquens | although the reaction is reversible, the activity of crotonyl-CoA carboxylase/reductase is up-regulated at least 60fold for Rhodobacter sphaeroides during growth with acetate versus succinate | up |
General Information | Comment | Organism |
---|---|---|
metabolism | the unique reductive carboxylation of crotonyl-CoA by the enzyme crotonyl-CoA carboxylase/reductase can be considered the committed step for acetyl-CoA assimilation by the ethylmalonyl-CoA pathway | Cereibacter sphaeroides |
metabolism | the unique reductive carboxylation of crotonyl-CoA by the enzyme crotonyl-CoA carboxylase/reductase can be considered the committed step for acetyl-CoA assimilation by the ethylmalonyl-CoA pathway | Streptomyces coelicolor |
metabolism | the unique reductive carboxylation of crotonyl-CoA by the enzyme crotonyl-CoA carboxylase/reductase can be considered the committed step for acetyl-CoA assimilation by the ethylmalonyl-CoA pathway | Methylorubrum extorquens |