Literature summary for 1.3.1.83 extracted from

Shpilyov, A.V.; Zinchenko, V.V.; Shestakov, S.V.; Grimm, B.; Lokstein, H.
Inactivation of the geranylgeranyl reductase (ChlP) gene in the cyanobacterium Synechocystis sp. PCC 6803 (2005), Biochim. Biophys. Acta, 1706, 195-203.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Synechocystis sp.	geranylgeranyl reductase catalyses the reduction of geranylgeranyl diphosphate to phytyl diphosphate required for synthesis of chlorophylls, phylloquinone and tocopherols	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Synechocystis sp.	Q55087	inactivation of the gene chlP encoding the enzyme in Synechocystis sp. PCC 6803. The resulting DELTAchlP mutant accumulates exclusively geranylgeranylated chlorophyll a instead of its phytylated analogue as well as low amounts of alpha-tocotrienol instead of alpha-tocopherol. Whereas the contents of chlorophyll and total carotenoids are decreased, abundance of phycobilisomes is increased in DELTAchlP cells. The mutant assembles functional photosystems I and II as judged from 77 K fluorescence and electron transport measurements. The mutant is unable to grow photoautotrophically due to instability and rapid degradation of the photosystems in the absence of added glucose. It is suggested that instability of the photosystems in DchlP is directly related to accumulation of geranylgeranylated chlorophyll a	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	geranylgeranyl reductase catalyses the reduction of geranylgeranyl diphosphate to phytyl diphosphate required for synthesis of chlorophylls, phylloquinone and tocopherols	Synechocystis sp.	?	-	?

Synonyms

Synonyms	Comment	Organism
ChlP	-	Synechocystis sp.
geranylgeranyl reductase	-	Synechocystis sp.

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Release 2023.1 (January 2023)