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Literature summary for 1.3.1.81 extracted from

  • Mahmoud, S.S.; Croteau, R.B.
    Menthofuran regulates essential oil biosynthesis in peppermint by controlling a downstream monoterpene reductase (2003), Proc. Natl. Acad. Sci. USA, 100, 14481-14486.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
additional information although (+)-menthofuran does not inhibit (+)-pulegone reductase activity, stem feeding with menthofuran selectively decreases enzyme transcript levels in immature leaves, thereby accounting for decreased reductase activity and increased pulegone content, overview, the flux of (+)-pulegone through pulegone reductase correlates negatively with the essential oil content of menthofuran, such that menthofuran, and pulegone increase, or decrease, in concert, overview Mentha x piperita

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
Mentha x piperita
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 (+)-pulegone + 2 NADPH + 2 H+ Mentha x piperita regulation of pulegone metabolism involves menthofuran, the flux of (+)-pulegone through pulegone reductase correlates negatively with the essential oil content of menthofuran, such that menthofuran, and pulegone increase, or decrease, in concert, overview (-)-menthone + (+)-isomenthone + 2 NADP+
-
?
additional information Mentha x piperita pathways for monoterpene biosynthesis in peppermint, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Mentha x piperita
-
cv. Black Mitcham
-

Source Tissue

Source Tissue Comment Organism Textmining
leaf
-
Mentha x piperita
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
essential oil composition of wild-type peppermint Mentha x piperita

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 (+)-pulegone + 2 NADPH + 2 H+
-
Mentha x piperita (-)-menthone + (+)-isomenthone + 2 NADP+
-
?
2 (+)-pulegone + 2 NADPH + 2 H+ regulation of pulegone metabolism involves menthofuran, the flux of (+)-pulegone through pulegone reductase correlates negatively with the essential oil content of menthofuran, such that menthofuran, and pulegone increase, or decrease, in concert, overview Mentha x piperita (-)-menthone + (+)-isomenthone + 2 NADP+
-
?
additional information pathways for monoterpene biosynthesis in peppermint, overview Mentha x piperita ?
-
?

Synonyms

Synonyms Comment Organism
pulegone reductase
-
Mentha x piperita

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Mentha x piperita