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Literature summary for 1.3.1.74 extracted from

  • Dick, R.A.; Kensler, T.W.
    The catalytic and kinetic mechanisms of NADPH-dependent alkenal/one oxidoreductase (2004), J. Biol. Chem., 279, 17269-17277.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-nonanone product inhibition, competitive versus trans-3-nonen-2-one Rattus norvegicus
additional information no inhibition by 9,10-phenanthroline Rattus norvegicus
NADP+ product inhibition, competitive versus NADPH Rattus norvegicus
Zn2+
-
Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information ordered Theorell-Chance kinetic mechanism, steady-state kinetics, detailed analysis, kinetic isotopic effects Rattus norvegicus
0.004
-
NADPH recombinant enzyme, pH 7.2, 25°C, with substrate trans-2-nonenal Rattus norvegicus
0.028
-
trans-3-nonen-2-one recombinant enzyme, pH 7.2, 25°C Rattus norvegicus
0.032
-
NADPH recombinant enzyme, pH 7.2, 25°C, with substrate trans-3-nonen-2-one Rattus norvegicus
0.078
-
trans-2-nonenal recombinant enzyme, pH 7.2, 25°C Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
additional information enzyme contains no Zn2+ Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus phase2/antioxidative enzyme ?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
a n-alkanal + NAD(P)+ = an alk-2-enal + NAD(P)H + H+ catalytic and kinetic mechanism Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information phase2/antioxidative enzyme Rattus norvegicus ?
-
?
additional information regio- and stereochemistry of hydride transfer, overview Rattus norvegicus ?
-
?
trans-2-nonenal + NAD(P)H
-
Rattus norvegicus nonanal + NAD(P)+
-
?
trans-3-nonen-2-one + NAD(P)H
-
Rattus norvegicus 2-nonanone + NAD(P)+
-
?

Synonyms

Synonyms Comment Organism
alkenal/one oxidoreductase
-
Rattus norvegicus
AOR
-
Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
assay at Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
additional information
-
pH-profile Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADH low activity, 20fold higher activity with NADPH Rattus norvegicus
NADPH dependent on, beta-specific Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information product inhibition kinetics Rattus norvegicus