Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.3.1.72 extracted from

  • Kohlhaas, J.; Jaeger, M.; Lust, L.; De La Torre, C.; Hecker, M.; Korff, T.
    Endothelial cells control vascular smooth muscle cell cholesterol levels by regulating 24-dehydrocholesterol reductase expression (2021), Exp. Cell Res., 399, 112446 .
    View publication on PubMed
Search for more literature for 1.3.1.72

Inhibitors

Inhibitors Comment Organism Structure
N,N-dimethyl-3beta-hydroxycholenamide
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5alpha-cholest-7-en-3beta-ol + NADP+ Homo sapiens
-
 5alpha-cholesta-7,24-dien-3beta-ol + NADPH + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HUASMC cell
-
 Homo sapiens
-
vascular smooth muscle cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5alpha-cholest-7-en-3beta-ol + NADP+
-
 Homo sapiens 5alpha-cholesta-7,24-dien-3beta-ol + NADPH + H+
-
 ?

Synonyms

Synonyms Comment Organism
24-dehydrocholesterol reductase
-
 Homo sapiens
DHCR24
-
 Homo sapiens
seladin-1
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens vascular endothelial cells have the capacity to instruct vascular smooth muscle cells to shut down the expression of the enzyme thereby limiting their cholesterol biosynthesis down

General Information

General Information Comment Organism
malfunction the blockade of the enzyme activity impairs adhesion, migration and proliferation of vascular smooth muscle cells Homo sapiens