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Literature summary for 1.3.1.72 extracted from
- High-density lipoproteins inhibit vascular endothelial inflammation by increasing 3beta-hydroxysteroid-DELTA24 reductase expression and inducing heme oxygenase-1 (2013), Circ. Res., 112, 278-288 .
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | vascular HO-1 and DHCR24 are knocked down by loading HO-1 and DHCR24 siRNA into the space between the collar and carotid artery at the time of collar implantation. Preincubation of human coronary artery endothelial cells with (A-I)rHDL before activation with tumor necrosis factor-alpha increases DHCR24 and HO-1 mRNA levels and inhibits cytokine-induced vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 expression. (A-I)rHDL-mediated induction of HO-1 is reduced in human coronary artery endothelial cells transfected with DHCR24 siRNA. Transfection of human coronary artery endothelial cells with HO-1 siRNA and tin-protoporphyrin-IX treatment does not inhibit the (A-I)rHDL-mediated increase in DHCR24 expression. Inhibition of phosphatidylinositol 3-kinase/Akt reduces the (A-I)rHDL-mediated increase in HO-1, but not DHCR24 expression. The activation of phosphatidylinositol 3-kinase/Akt by (A-I)rHDL is decreased in human coronary artery endothelial cells that are transfected with DHCR24 siRNA | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Homo sapiens | 16020 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cholesta-5,24-dien-3beta-ol + NADPH + H+ | Homo sapiens | - |
cholest-5-en-3beta-ol + NADP+ | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q15392 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| coronary artery endothelial cell | - |
Homo sapiens | - |
| endothelium | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cholesta-5,24-dien-3beta-ol + NADPH + H+ | - |
Homo sapiens | cholest-5-en-3beta-ol + NADP+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 3beta-hydroxysteroid-DELTA24 reductase | - |
Homo sapiens |
| DHCR24 | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Homo sapiens | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | (A-I)rHDL-mediated induction of HO-1 is reduced in human coronary artery endothelial cells transfected with DHCR24 siRNA. The activation of phosphatidylinositol 3-kinase/Akt by (A-I)rHDL is decreased in human coronary artery endothelial cells that are transfected with DHCR24 siRNA | Homo sapiens |
| physiological function | lipid-free apoA-I and (A-I)rHDL inhibit inflammation by increasing DHCR24 expression, which, in turn, activates phosphatidylinositol 3-kinase/Akt and induces HO-1 | Homo sapiens |
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Release 2023.1 (January 2023)
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