Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.3.1.72 extracted from

  • Zerenturk, E.J.; Kristiana, I.; Gill, S.; Brown, A.J.
    The endogenous regulator 24(S),25-epoxycholesterol inhibits cholesterol synthesis at DHCR24 (Seladin-1) (2012), Biochim. Biophys. Acta, 1821, 1269-1277.
    View publication on PubMed
Search for more literature for 1.3.1.72

Cloned(Commentary)

Cloned (Comment) Organism
expressed in CHO cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
24(S),25-epoxycholesterol incubation with 24(S),25-epoxycholesterol results in accumulation of desmosterol at the expense of cholesterol, consistent with inhibition of DHCR24 activity Cricetulus griseus
24(S),25-epoxycholesterol incubation with 24(S),25-epoxycholesterol results in accumulation of desmosterol at the expense of cholesterol, consistent with inhibition of DHCR24 activity Homo sapiens
Triparanol
-
 Cricetulus griseus
Triparanol
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Cricetulus griseus
-
-
-
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
CHO cell
-
 Cricetulus griseus
-
Hep-G2 cell
-
 Homo sapiens
-
neuronal cell line BE(2)C cell line Homo sapiens
-

Synonyms

Synonyms Comment Organism
3beta-hydroxysterol DELTA24-reductase
-
 Cricetulus griseus
3beta-hydroxysterol DELTA24-reductase
-
 Homo sapiens
DHCR24
-
 Cricetulus griseus
DHCR24
-
 Homo sapiens
seladin-1
-
 Cricetulus griseus
seladin-1
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction DHCR24 overexpressed in CHO cells show that untreated CHO-DHCR24 cells have a higher cholesterol to desmosterol ratio. In the CHO-DHCR24 cells, more 24(S),25-epoxycholesterol is required to attain the same cholesterol to desmosterol ratio as in CHO cells expressing an empty vector. Thus, with DHCR24 overexpression, the effect of 24(S),25-epoxycholesterol on the cholesterol to desmosterol ratio is blunted Homo sapiens